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Methylation, B12, Glutathione, etc.

Some patients have symptoms consistent with a deficiency of methyl donors such as SAMe/AdoMet, either localized to brain regions or elsewhere. Other patients report strange reactions with B vitamins, especially B12 or folate, but without any obvious explanation. This is the place to discuss B vitamins, methyl donors, glutathione, etc.
S
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Why are B12 supplements making my symptoms so much worse?
2 3 4
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73
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6K
Wanja
Wanja
Mr. Cat
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Glutathione causing anxiety/irritability
2 3 4
Replies
77
Views
14K
skaffa
S
nerd
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What is your understanding of the methylation cycle trap or blockage?
2 3 4
Replies
61
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11K
daniariete75
D
C
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The plausibility of NAC inducing b12 deficiency or 'methyl-trap'
2 3
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49
Views
12K
GreenMachineX
G
Hip
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CAUTION: Vitamin B12 Sublinguals — The Citric Acid Additive Can Erode Tooth Enamel
6 7 8
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143
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91K
Hip
Hip
Pyrrhus
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  • Poll
B12: a simple 5-second poll for everyone
2 3 4
Replies
73
Views
13K
heapsreal
heapsreal
Pyrrhus
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Low glutathione in ME/CFS brain: a pilot magnetic resonance spectroscopy study at 7 Tesla (Godlewska et al., 2021)
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16
Views
5K
lenora
L
ahmo
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Favorite Choline?
2
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28
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13K
Pyrrhus
Pyrrhus
Gondwanaland
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Supplementation with high concentrations of synthetic B6 (pyridoxine) leads to decreased natural vitamin B6 (pyridoxal) function
2
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23
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7K
Gondwanaland
Gondwanaland
R
  • Locked
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Documents by Rich Van Konynenburg: Parts 1-7
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7
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56K
richvank
R
C
How to get in touch with Fredd
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1
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74
Judee
Judee
C
New treatment
Replies
1
Views
106
Judee
Judee
CSMLSM
Found a source of B12 comparable to injection that only contains the 2 active forms + pure water.
2
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26
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523
Rufous McKinney
Rufous McKinney
dannybex
Low potassium symptoms?
2 3
Replies
51
Views
3K
lenora
L
D
Pyroluria, is it real? I'm really skeptical and here is why.
6 7 8
Replies
141
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33K
acrosstheveil
acrosstheveil
F
Active B12 Protocol Basics
47 48 49
Replies
969
Views
344K
Larry_Origins
Larry_Origins
S
Post your current ME/CFS supplement stack and what you're thinking about next.
2
Replies
20
Views
1K
Nacht Segler
Nacht Segler
Hip
Very noticeable improvements in brain fog using Dr Greg Russell-Jones's transdermal B12 oils (which provide a similar dose to B12 injections)
9 10 11
Replies
204
Views
38K
Johnmac
Johnmac
acrosstheveil
High Quality B12
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14
Views
855
Johnmac
Johnmac
judyinthesky
B12 pooling in blood
Replies
2
Views
121
JES
JES
caledonia
Start Low and Go Slow - How to Be Safe On A Methylation Protocol
2 3
Replies
42
Views
13K
caledonia
caledonia
linusbert
Hypoglycemia symptoms without actual hypoglycemia (could it be a hypokalemia issue instead)?
Replies
9
Views
476
kangaSue
K
chilove
Looking for a very clean hydroxy B12 with no or minimal additional ingredients
Replies
1
Views
79
linusbert
linusbert
linusbert
How long is Bodybio Phosphatidylcholine good after opening?
Replies
2
Views
96
linusbert
linusbert
Katy131
What is the role of Phosphatidyl Serine in the methylation protocols?
Replies
1
Views
145
YippeeKi YOW !!
YippeeKi YOW !!
HurrySaveMe
If glutathione supplements are so bad for B12 deficiency cases, why does Liposomal Glutathione help me so much momentarily?
Replies
8
Views
540
cheeseater
C
Katy131
Which comes first - the Methyl folate or the Methyl cobalamin (and other questions)? Discuss :)
Replies
6
Views
257
Katy131
Katy131
B
B2 I love you!
65 66 67
Replies
1K
Views
350K
Omgitsremy89
O
caledonia
Managing Potassium Deficiency - Share your experience
22 23 24
Replies
467
Views
81K
TinaT
TinaT
J
Those who have stopped methyl supps due to bad reaction, how long did it take to get back to normal?
2 3
Replies
56
Views
8K
caledonia
caledonia
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