Have you tried uridine, as 5'-uridine monophosphate, by any chance? And if so, how did it compare to citicoline (CDP-choline)?In my experience, Alpha GPC is a pure cholinergic, whereas citicoline also affects dopamine.
Alpha GPC gave me headache, muscle tension and depression, signs of acetylcholine overload, but I know others do well with it.
Citicoline works like a mild stimulant. It helps with concentration (ADHD type problems), which pure cholinergics often does not.
I guess it depends on what you're looking for. Or try both and see which one you like.
No, I haven't tried pure uridine. I'm aware that citicoline breaks down to this.Have you tried uridine, as 5'-uridine monophosphate, by any chance? And if so, how did it compare to citicoline (CDP-choline)?
I get over stimulated. Taking dopamine is a problem for me so I was thinking Citicoline and Alpha GPC were out.Citicoline and Alpha GPC are both far superior to Phosphatidylcholine. The evidence of Phosphatidylcholine being helpful for anything but liver disease is poor, no matter how much they try to hype their marketing.
Yeah, the problem is that PC doesn't have much of an effect in the CNS. It's mostly peripheral. Citicoline and Alpha GPC are effective at raising choline levels in the brain.Or is the whole issue that Phosphatidylcholine doesn't cross the BBB?
It may be somewhat premature, but for those of you asking about supplements to boost phosphatidyl-choline:
I can share what I have in my notes about choline, which may help:
Lecithin contains phosphatidyl-choline (PC), which is one of the three main forms of supplemental choline.
100mg PC contains 13mg choline.
The other main forms of supplemental choline are citicoline (CDP-choline) and glycero-phospho-choline (GPC).
100mg GPC contains 40mg choline.
Milk contains both PC and GPC. Both PC and GPC are naturally found in the brain.
CDP-choline is temporarily made by the body when synthesizing its own PC.
Since choline synthesis in the body consumes a large percentage of the body's methyl donors, taking supplemental choline should free up a large percentage of the body's methylation capacity.
Choline should not be taken at the same time as carnitine, as they compete with each other for transport across the blood-brain-barrier.
In my own personal case, a single dose of 300mg glycero-phospho-choline (GPC) caused temporary start-up effects of headache, weakness, worsened brain fog, worsened light/sound sensitivity, depression/irritability, preceded by a brief burst of energy and appetite loss.
Eventually these start-up effects faded and I was able to tolerate two daily doses of 300mg GPC without any problems. For what it's worth...