I take little amounts, and it has had a good effect last spring and this spring again, but was lacking any effect in autumn. It is the ordinary form which I take.
I have tried a lot of supps now, and in most cases it´s effective in little doses as I drink it in sips (drinking a sip with the supp in water and then later again). This is on top of an avoidance.
I also tried injections (hydroxy-form), but the effect didn´t last very long, instead the stiches lasted, so I dropped it.
Finally, I also tried the methyl-form (it was sublingual), but there wasn´t any effect at all (it might have been in autumn, can´t remember).
My interpretation was firstly that it is an anti-NO effect, whereas here on the forum it was discussed as affecting the methylation cycle (if I got it right), and B9 was part of this interpretation. But I get negative effects from B9, for what ever reason.
With the methylation though there might be something. I will look again in autumn, when NO might be in my body lower (my impression only). I say this because I have good effects from acetate (very small dose), and acetylation is known to take place e.g. in epigentics, as B12 methylation is.
I think an influence on epigentics is not in itself necessary useful, but may easily depend on good circumstances, so I wonder why in the past the B12 thing has been considered that helpful, but didn´t read through the theory.