With the methylation though there might be something. I will look again in autumn, when NO might be in my body lower (my impression only). I say this because I have good effects from acetate (very small dose), and acetylation is known to take place e.g. in epigentics, as B12 methylation is.
I think an influence on epigentics is not in itself necessary useful, but may easily depend on good circumstances, so I wonder why in the past the B12 thing has been considered that helpful, but didn´t read through the theory.
I did, BTW, and B12 has a good effect this year. I think nevertheless that methylation is not the reason. The effect comes promptly and the intake is easily overdone.
Inhibitory stuff that can work for me are: Cl and K (both have just stop to work on a wider scale); acetate (this now not in this autumn, though in the last one, which might be an argument against methylation as there is an acetylation as well), B12, and Vitamin C
Citrate works in the same felt manner, but it has been shown rather to elevate nitric oxide (via oxalacetate).
I think that all this stuff works preferably in different section of some brain structures, and for geometrical reasons, there could be a sequence to take them, and an optimal amount. I think now it could be: B12 - Cl - Citrate - Acetate (these lst ones have been the start in the year before). Potassium is extra, on its own.
With that in mind, my 500mcg is a tiny amount!
