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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. Sequestered Hog

    Injecting b12 - any tips advice

    Hello everyone, Following a consultation with Dr Bansal (UK immunologist) I have finally got round to the B12 injection part of his advice. I seem to recall the Dr. Telling me to inject into the belly fat, however I have just found a YouTube video which seems to suggest the upper arm area to...
  2. jason30

    Can B12 injections deplete other nutrients?

    Hi all, I am taking B12 injections for a year now. I know that it lowers potassium so I take potassium as well. But are there any other vitamins or minerals which get depleted by B12 (hydroxocobalamin) injections? Thanks for thinking along.
  3. P

    Abruptly stopped methylating B12 and folic acid?

    Hi all, I’m really suffering and anxious and hoping someone can help me. I’ve been injecting B12 and B9 every other day for autoimmune atrophic gastritis (aka ‘pernicious anaemia’) for several years now. Specifically, I inject hydroxocobalamin and folic acid. These had been addressing...
  4. ironlion37

    Has Anyone Used Micron Filters with B12?

    I have some B12 powder that I want to inject (with saline). However, I need to run it through a sterile filter to ensure that it's sterile and safe. Has anyone done this before with B12? I'm curious if a 22 micron filter would end up filtering the B12 itself out of the solution. Example...
  5. ironlion37

    Staggering Incompetence

    I've just been in touch with Arnika Apothecary in Germany. They are an often quoted source of methylcobalamin ampules. Before ordering from them, I inquired as to their light exposure precautions during production. This is their response: "We manufacture the methylcobalamin ampoules in our...
  6. A

    Plausible Lithium-B12 connection or AI garbage?

    Here’s the final result of pushing gpt-4 into finding a connection between lithium supplementation and b12 uptake by the cell: When asked about alternative mechanisms by which lithium could exert its influence: Not evaluated for hallucinations, take everything with a grain of salt. But, any...
  7. ironlion37


    Hi, I saw a link to an article about this product "MecobalActive." The article stated that it is a cleaner form of methylcobalamin. It seems that the company that produced this product no longer exists. In response to a decline in my health, Oxford Biosciences admitted that they switched...

    Found a source of B12 comparable to injection that only contains the 2 active forms + pure water.

    https://natureprovides.com/products/bioactive-liquid-vitamin-b12-uk Bioactive B12 is a potent and bioavailable blend, containing both of the most active forms of B12: Dual Coenzyme Methylcobalamin and Adenosylcobalamin. With NO artificial preservatives and colourings - and held only in pure...
  9. Bansaw

    Whats a good effective form of B12 to get my levels up ? (my labs showed 114 pg/ml)

    I took a blood test to find out B12 levels. My result was 114 pg/ml (normal range 180-914pg/ml). What's a proven effective B12 supplement (brand/dose) that will help get my levels back to normal? I developed type 2 diabetes a year ago, I think this has something to do with my depleted levels...
  10. HurrySaveMe

    Can anyone help me make sense of why I react to Glutathione the way that I do?

    Whenever I take Liposomal Glutathione, I initially feel a lot better for a short while. My brain fog, derealization and cognition gets better, it feels like my brain wakes up again. But afterwards I crash, and feel even worse. Why does this happen to me? I've been able to find out through tests...
  11. S

    Why are B12 supplements making my symptoms so much worse?

    Hi, I just wondered if anyone knew why B12 greatly worsened my symptoms? I had an adverse reaction to an antidepressant in January, and since I have been struggling with various symptoms. I had covid in march, which made it all worse and I have struggled with fatigue and bad brain fog...
  12. W

    How long does it take for methylation to show full effect

    Hello! I've been on a methylation protocol for 2 months now. After 2 weeks I saw some improvement which has been on and off and not really progressed since then. Is this what I can expect for the future or is there a chance that I will continue to improve at say 6 months, 9 months, 1 year...
  13. S

    Help digesting Freddd's protocol for B12

    Hi, I need some help getting to the protocol or the latest consensus on the exact protocol. Which Supplements, Brands and Amounts are recommended today? Every thread I try to read through just makes me more confused Lol. Thanks for anyone's help!
  14. D

    My experience of B12/methylation issues. Looking for advice/discussion please

    Sorry for the long post, I wanted to give my full history. Thanks to anyone that reads it. My questions are at the end if you want to skip. History First of all, I suffer from the C677T mutation of the MTHFR gene. I have a few other mutations that may affect methylation but I don't understand...
  15. Waverunner

    Tingling hand and feet; worsening by folic acid and B12 supplements

    Hi all, had some strange issues for several weeks now. I suffer from pretty bad food intolerances that seem to evolve over time. Three to four weeks ago I started to have strong dizziness, tingling hand, and feet, increased fatigue, and nausea. These symptoms last for several days but get...
  16. gbells

    Epstein Barr virus causes megaloblastic anemia (methylation related)

    I was troublesheeting a high MCV on CBC labs and learned that Epstein Barr virus causes it (megaloblastic anemia). It is a deficiency of activated folic acid and activated B12. I am heterozygous for MTHFR deficiency but never had a problem with it before EBV infection in 2008. Post infection...
  17. K

    Hydroxocoblamin not converting to Adensoylcoblamin

    Hello all, I am taking a hydroxy b12 and Folinic acid lozenge along with plenty of riboflavin in the AM as I am MTHFR c677t double, but my MMA does not lower. I am also Comt ++ so methyl does not work for me/causes neurotransmitter issues. If I take an Adensoylcobalmin b12 lozenge in the PM...
  18. K

    Dysautonomia worse treating B12

    Hello all, It appears we finally have the right approach and my MMA levels are coming down. I have already upped my potassium. My dysautonomia seems to be getting worse. Anyone else experience worsening while treating? I suspect it’s the cells being created and nerves healing... at least I hope...
  19. K

    Two Forms of B12 at Once = No Absorption?

    Hello all, After identifying my B12 deficiency via an MMA test (623) we tried methyl shots with methylfolate but found I was having neuropathy. Stopping both methyls cleared up the neuropathy and using an hydroxy b12 1000mcg/Folinic acid lozenge in the AM along with an Adensoyl b12 1000mcg...
  20. B

    Telemedicin Docs that will prescribe B12

    I was actually brought here by the "Where Can I get Hydroxocobalamin without a prescription?" thread. I've been reading Martin Pall's stuff and want to try some of his suggestions. Injecting B12 in the form of hydroxocobalamin seems like the most potent strategy of his. Looking at that thread...
  21. Regiesh

    Methyl Cobalamin Crash?

    I started taking 1mg of methyl cobalamin recently. It really helps me with energy throughout the day but I always seem to have an extreme somewhere between 5-7pm. Is it safe for me to take a second 1mg methyl cobalamin around 5pm to potentially prevent the crash? Is this common? I'm sensitive to...
  22. Pyrrhus

    B12: a simple 5-second poll for everyone

    This is a simple 5-second poll for anyone who has ever tried a B12 supplement in any form. Many thanks to everyone who responds! Please feel free to share your experience in more detail in a post.
  23. J

    Burning GI, Rapid Weight Loss, Usually After B12 Supplementation

    I've got several health issues, but one of the most debilitating is states during which I experience 5/10 GI burning, burning throughout arms, hands, face, etc. and rapidly lose weight. These episodes seem to come up naturally, often after periods of stress or little sleep but are guaranteed...
  24. J

    Losing Progress, Looking for Next Step

    I've been dealing with health issues the past 6-7 years and while making some serious headway, I've recently started to backslide and am not quite sure of my next step. I'm starting to feel like I'm entering the final phase of my ability to manage symptoms and looking for a helping hand in...
  25. C

    The plausibility of NAC inducing b12 deficiency or 'methyl-trap'

    Hello everyone. I am writing because I am particularly interested in the evidence for NAC inducing b12/b9 deficiency. I have thus far given the forums a cursory perusal and I have gathered that the event of b12 deficiency is plausibly linked to previous NAC supplementation. I had b12 deficiency...
  26. jason30

    My B12 is dropping very fast, what could be the cause?

    Hi all, My B12 is dropping very fast and I start with injections or the Greg's B12 transdermal oils soon. But I wonder if someone have an idea why B12 could drop so fast? 2015 June: MMA: 0,09 B12: 467 Active B12: Not measured 2018 April: MMA: 0,23 B12: 351 pmol/l Active B12: Not measured...
  27. W

    Alternative ways to get extra potassium?

    I've finally got my methlyation up enough that my need for potassium has increased. However, I'm having a problem getting potassium into my body. My digestive system will not absorb more than 50 mg/day if that when I take supplements and that's spread out. I think this is partially due to being...
  28. Hip

    Very noticeable improvements in brain fog using Dr Greg Russell-Jones's transdermal B12 oils (which provide a similar dose to B12 injections)

    For the last few months I have been using the methylcobalamin + adenosylcobalamin vitamin B12 transdermal oil developed by Dr Greg Russell-Jones in Australia, which he recommends for ME/CFS. This transdermal B12 oil has made very noticeable improvements in my brain fog and cognitive clarity...