Here's Dr. Russell-Jones reply regarding these studies:
In paradoxical B12 deficiency, you have very elevated B12 (as most people with CFS have), yet the B12 in inactive, or largely so. This is the same in the studies where they have looked at cancer, and they find this odd curve where cancer rates are higher both at lower B12 and also at higher B12 levels.
As you know B12 is responsible for methylation and methylation is required to suppress the expression of some cancer genes. This then explains why at low B12 levels you get some cancers that are more expressed. It also though explains it at very high B12 levels - such as you see in CFS. Hence the higher the B12, then more of the B12 is inactive, and in OAT you see the traditional markers of B12 deficiency get higher and higher, with MMA being one that most people would know, but there are a whole swag of other markers of B12 deficiency that get paradoxically higher as B12 levels get higher and higher.
Paradoxical B12 deficiency. Hence, as levels get higher, methylation gets lower (as everyone on the Phoenix rising site would know - I presume), and so the ability to turn off cancer genes also gets lower, so the rates get higher.
There are a couple of other quirks, in that certain steroid dependent cancers also have higher incidence in paradoxical B12 deficiency, because COMT, which uses SAM, the "universal methyl donor", is required to inactivate things like estrogen, so one would expect ER+ cancers to be higher in paradoxical B12 deficiency.
We're not worried because we have none of those man-eating things like lions, tigers, wolves or real bears.
