Lassesen

The numbers of PubMed studies on the human microbiome have exploded in the last few years as shown in the chart below. In the early 1990’s we had around 10 studies a year. In 2017 we reached 4421 studies — a massive increase and expect at least 4000 every year going forward. This creates a...
This post comes out of a 2018 article: Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function. [Sep 2018]. The basic findings was: Of these, Veillonella abundance was significantly different between CFS patients and healthy controls, with 9.81 ±...
Lassesen
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I just got my ubiome results today. The sample was taken after one month on Seed Probiotics. I believe that the Seed Probiotics have made a significant positive impact on me, but the impact that I was most hoping for was seeing more lactobacillus AND bifidobacterium being reported. The answer...
Lassesen
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Recap of this Journey For new readers: I have had Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) three times in my life and recovered each time. As a result of work stress, I am currently in a ‘flare’, because it was sudden onset and I realized what it was on day one and took...
Lassesen
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This item has been on my backburner for a while and today I came up with an efficient algorithm to compute a short most probable symptoms. The results on my own samples were actually quite accurate. I have MTHFR issues (reported by conventional testing), this is my age range, cold hands and...
Lassesen
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Doing a few more hours of reviewing PubMed studies, I came across “Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome” [2017] There were some interesting findings. Increased abundance of unclassified Alistipes and decreased...
Lassesen
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A friend asked about how to modify their diet to minimize the impact of doxycycline. I had an old page on that but discovered that it was both broken and inconsistent with revisions and new features. I have brought it up to standards. Process Step 1: Find the Drug Antibiotics Other Drugs For...
Some readers have requested that I show the list of bacteria that were selected to make suggestions from. I have done some refactoring and they are now available from three different ways of selecting bacteria that are available on the site now. Reports go down to the strain in some cases...
Lassesen
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There is a lot of uncertainty in modifying an ill microbiome. This starts with selecting the bacteria you want to change, see this post Steeing the species that may need correction to whether something actually modifies a bacteria without causing undesirable side-effects. You cannot be blinkered...
I have added a new page today that shows the relative production of various vitamins and a few metabolites compared to a healthy population. It is linked to from the samples page. Each sample will give different results The regular suggestions pages may list these vitamins because it is known...
Lassesen
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This week I applied an old technique to microbiome analysis which I remember using to solve some messy problems that I was dealing with professionally back in 1982. The solution was to return to the question or assumption without going down the path mostly travelled. Almost all of the microbiome...
Lassesen
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I have just pushed a new update to the http://microbiomeprescription.azurewebsites.net/ website. The new page lists bacteria associated with specific symptoms and conditions. Finding Gender specific bacteria shown above agrees with research Right Thinking Almost all published studies report...
Lassesen
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If you look at different strains of a probiotic such as Lactobacillus Reuteri and dig far enough into research papers — you will see charts like the one below. From prediction to function using evolutionary genomics: human-specific ecotypes of Lactobacillusreuteri have diverse probiotic...
Lassesen
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In general, I prefer single species or single strain probiotics that has studies on PubMed. On occasion, a probiotic mixture makes it to my “second line probiotics to try”. There is a new pair on the market (one for men, one for women) that passes the bar. What is my bar? All of the strains...
Lassesen
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I have been on long term disability for ME/CFS, had to deal with school boards for children with ME/CFS and often seen ad-hoc reports created by well meaning MDs. These situations are often legal situations and not medical treatment scenarios — I have seen reports missing the mark — often...
Lassesen
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Myalgic encephalomyelitis is a complex disease, likely the most complex known by several magnitudes. The symptom list is massive. Looking for clustering at the patient level finds a vast array of sensitivities that makes one plan for everyone impossible, but even a dozen plans are improbable to...
Lassesen
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I just received my uBiome report for a sample taken 6 days after a sudden onset ME flare. It was sudden onset because over 15 minutes I could feel my entire body shift and booked off sick for the rest of that day (and following week). The cause was stress, the cause of 40% of ME cases according...
Lassesen
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I usually avoid getting too involved with readers — for a simple reason: this blog and the microbiome analysis site is already a time consuming evening and weekend gig (full time IT day job). I am not a physician or medically trained, so “patient history” is an inappropriate term to use. This...
Lassesen
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Another interesting article popped out of the AI selected articles: Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with...
Lassesen
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My eye caught a news story today Common food additive may impact gut bacteria, increase anxiety. Earlier studies have shown that emulsifiers can alter the microbiome of mice, causing low-grade inflammation and increasing the risk of obesity and metabolic disorders. A study in humans concluded...
Lassesen
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