A reader wrote with a concern for the person she is caring for.
- Histamine Issues
- Salicylates issues
- Thick blood issues
- D-Lactic acid issues
- Gluten issues – which can occur with supplement fillers
I’ve been involved with the ME community for about 20 years and seen a lot of fads, trends and a few successes. Too often the same concept gets tried, retried and retried again in the community with the same result — no result.
The following are from interactions that I have had with various people over these years
Many probiotics are histamine producers. Taking an random probiotic may make things worst. For more reading:
- Probiotics and Histamines
- Bacillus Probiotics
- Histamine Intolerance – my best suggestions
- E. Coli is a histamine produce 
Histamine issue may be due to over population of:
- Proteus mirabilis, [ref]
- Streptococcus pneumoniae [ref]
- Klebsiella pneumoniae (also produces lactic acid) [ref]
See Salicylate sensitivity for some background. This can mean that something like aspirin that could assist with thick blood, may make things person. This also applies to many herbs and spices that are effective against some bacteria or blood thinning.
This deselects a lot of items and tend to increase the importance of probiotics, minerals and non-herbal supplements.
Thick Blood Issues
First, thick blood issues can be tricky because there can be many different coagulation mechanism involved. Doing too much of the wrong thing can result in easy bleeding and bruising (I have gone there). Coagulation: Thick Blood Supplements for CFS. Possible actions can be split into three types:
- Prescription: Heparin (sublingual — under the tongue, seems to work as well as injection for ME)
- Salicylate free supplements (not plant based):
- Alpha Lipotic Acid
- Salicylate risk
- Grape Seed Extract
- Boswelia Gum
This is usually impacted by probiotics as well as dairy consumption. Lactic acid is not produced only by lactobacillus, but also
Leuconostoc mesenteroides and Pediococcus. See:
- Approaches to d-lactic acidosis
- BIFIDO|MAXIMUS Histamine-Free and D-Lactate Free Probiotic
- Bacillus probiotic are likely safe as well as Equilibrium or Prescript Assist.
What to do?
The key factor is not to create fog on what is happening by ingesting the kitchen’ supplement cabinet. I would start by assuming histamine issues, lactic acid issues and salicylates issues. This leads to two sets of things to test for response (ideally one at a time for 2 weeks):
- Probiotics: Equilibrium, Prescript-Assist, Enterogermina and similar.
- Safe blood thinners: Alpha Lipotic Acid, Serrapetase, Lumbrokinease, Nattokinease, Piracetam
Remember, every person’s path to remission and relief is likely unique.