• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Valtrex (GSK version) - 500mg three times a day - day 4

Learning a lot I feel at the moment even if it's in the absence of pathology tests I am going off symptoms.

I did a lot on Saturday and Sunday morning felt pretty good, but then I took a higher dose of valtrex and became really tired after that, this tiredness lasted all day. The higher dose was an experiment where I took 1g three times a day to see if it would get some canker sores in my mouth under control. I believe these canker sores could be high CMV titers, because I had cmv come up high on an elisa in 2018 and valtrex doesn't hit cmv very well at all.

After 3 days on valtrex I noticed that my dry mouth and ulcer (the one I normally get) was back and wasn't going away. Then again I also felt tired and sleepy more, which could be lvier or kidney issues, or it could just be the effect of the medication. Blood tests on Thursday should tell the story.

At any rate the ulcer was getting really bad and the valtrex didn't dent it even at higher doses. I have a theory that this is because it doesn't hit CMV it's also possible the tiredness is being caused by cmv. But these drugs take months to work so the fact I went out 3 seperate times on Saturday and did a lot more than usual tells me they do work, it's just that it takes time for you to feel really good every single day.

Today I took 250mg famvir in the morning, it was an experiment to see whether it would impact my ulcer. It did and 3 hours later the ulcer is not only in check but starting to heal. I don't think this is placebo personally.

However the side effects of the famvir are still pretty bad, very dizzy/disorientated and feel a lot less coordinated physically, but not so bad I am worried about liver or kidney function issues.

I intend to get my CMV tested sometime soon, although the costs all this treatment is mounting.

I am still fascinated by how badly I reacted to the indian generic valtrex compared with the european valtrex. Honestly it's been night and day the difference it's made. On valtrex I've had zero side effects, I am certain that the slgihtly dry mouth and sore is a product of a virus, I am pretty sure it's not sjrogens as I don't have any positive auto immune tests nor is any other part of my body dry when I get this issue. Plus I had it before I got ME, when I was 24 I had some issues and I think that was just due to circumstance, but nobody else seemed to suffer like me, so I assume therefore that it's viral or something else that I've got.

I've done a lot of research about famvir and it does hit cmv better than valtrex, but not as well as valcyte. I find it strange that famvir would be so good at getting rid of the canker sore and allowing it to heal, where valtrex just isn't capable.

I'm also glad the side effects are not so bad I can't keep working or focussing at work and I have had zero issues sleeping with valtrex.

I actually feel calm and relaxed on valtrex - with fewer ME symptoms for the first time in years. I haven't felt calm but well in ages.

Two days after I came off the famvir my ME symptoms came STRAIGHT back. I woke up with PEM, fatigue and malaise and my throat was on fire, it was incredibly sore. Within 45 minutes of taking 500mg of GSK valtrex the sore throat was 50% better and a load of other symptoms were improving.

So waiting to see what my blood tests look like now and waiting on some new famvir to arrive that will hopefully have less side effects.


Hi there, I found this post by searching for "mouth sores". I get them bad along with fatigue and feeling "flu-ish". Have you found a combination that works for you and keeps them away?
Hey. So it depends what is causing them if it's hsv it should respond to an antiviral like famvir or valtrex. If it's due to poor metabolism with the ME and dry mouth (might be autoimmune but prob just dysautonomia) then this is much harder to control. I still get them, but I couldn't really tell you what stops them.

Probably a combination of nac 1g 3x a day, egcg 200mg a day, reishi life extension 3 caps 3x a day and a good quality probiotic. That's it really, just these things seemed to make a huge difference.
I'm a Covid Long Hauler and my main symptoms are extreme debilitating fatigue and persistent low grade fever, no cold sores/ulcers and no sore throat. I got tested for EBV and everything was negative (Dr did not include EBV early antigen) but EBNA was off the chart over 600 and i have apparently lost my EBV VCA IgG (negative). I have a couple of acyclovir pills lying around and it seems to help with the low grade fever but I'm not sure if it's due to the drug's Antiviral or antiinflammatories activities? Dr also tested for CMV. IgM was negative, IgG was 2.10 (positive is anything over 0.69).

I'm seeing more prominent blue veins all over my body. My right leg would go numb when I lay on my stomach or on the side. Can any of the herpes viruses cause damage to the veins? Do you think I'm dealing with EBV or CMV or is it something else?

My condition just kept getting worst so I'm unable to go get tested at the moment. Do you think I should buy generic valtrex or generic Famvir? Thank you
Last edited:
You can try but it may not be the ebv that is driving it. Valtrex will barely touch cmv and famvir isn't very good for that either.

It's worth trying 1g a day. See Dr Bansal if you're in the UK.

I have just read a study where LC patients took nicotine patches 7mg per day and they saw massive improvement in all symptoms within 3 days. Especially brainfog. Might be worth trying.

Valtrex is superior to acloyvir btw.

Blog entry information

Read time
3 min read
Last update

More entries in User Blogs

More entries from godlovesatrier

  • Covid day 75
    Well since my last few updates I started to suffer from exhaustion and...
  • Covid Day 59
    After herxing a lot yesterday taking 250mcg of kpv for a bad head cold...
  • Covid day 56
    I started to feel better around day 40, lactoferrin 900mg a day...
  • Covid update
    Lung pain has definitely gone since taking two 5mg hydrocortisone doses...
  • Covid day 39
    I've got air hunger now which I haven't had for about two or three...