It may be some time before I can put together a coherent blogpost on animal research related to the gut microbiome and ME (I'm always pressed for time) so here is some more general info originally posted in the 'Other Health News and Research' forum.
REFERENCES
Auer, J.A., Goodship, A., Arnoczky, S., Pearce, S., Price, J., Claes, L., von Rechenberg, B., Hofmann-Amtenbrinck, M., Schneider, E., Müller-Terpitz, R., Thiele, F., Rippe, K-P. and Grainger, D.W. (2007) Refining animal models in fracture research: seeking consensus in optimising both animal welfare and scientific validity for appropriate biomedical use, BioMedCentral Musculoskeletal Disorders, vol. 8, Article 72, online at http://www.biomedcentral.com/1471-2474/8/72
Goozee, R. (2007) Failing Faster, Next Generation Pharmaceutical Magazine Issue 3, March 2007, online at http://www.ngpharma.eu.com/article/Failing-faster (accessed 13.6.10)
Hartung, T. (2009) A toxicology for the 21st century - mapping the road ahead, Toxicological Sciences, vol. 109, no. 1, pp. 18-23, online at http://toxsci.oxfordjournals.org/cgi/reprint/109/1/18.pdf
Hoffmann, S., Edler, L., Gardner, I., Gribaldo, L., Hartung, T., Klein, C., Liebsch, M., Sauerland, S., Schechtman, L., Stammati, A. and Nikolaidis, E. (2008a) Points of Reference in the Validation Process, The Report and Recommendations of ECVAM Workshop 66a, Alternatives to Laboratory Animals vol. 36, pp. 343-352, downloadable from
http://www.frame.org.uk/atla_article.php?art_id=1084&abstract=true
Hoffman, S., Gallegos Saliner, A., Patlewica, G., Eskes, C., Zuang, V. and Worth, A.P. (2008b) A Feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals, Toxicology Letters, vol. 180, pp. 9-20, abstract online at http://www.ncbi.nlm.nih.gov/pubmed/18585875
van der Worp, H.B., Howells, D.W., Sena, E.S., Porritt, M.J., Rewell. S.,O'Collins, V. and Macleod, M.R. (2010) Can Animal Models of Disease Reliably Inform Human Studies? Public Library of Science Medicinevol. 7, Issue 3, e1000245, online at http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000245
REFERENCES
Auer, J.A., Goodship, A., Arnoczky, S., Pearce, S., Price, J., Claes, L., von Rechenberg, B., Hofmann-Amtenbrinck, M., Schneider, E., Müller-Terpitz, R., Thiele, F., Rippe, K-P. and Grainger, D.W. (2007) Refining animal models in fracture research: seeking consensus in optimising both animal welfare and scientific validity for appropriate biomedical use, BioMedCentral Musculoskeletal Disorders, vol. 8, Article 72, online at http://www.biomedcentral.com/1471-2474/8/72
Goozee, R. (2007) Failing Faster, Next Generation Pharmaceutical Magazine Issue 3, March 2007, online at http://www.ngpharma.eu.com/article/Failing-faster (accessed 13.6.10)
Hartung, T. (2009) A toxicology for the 21st century - mapping the road ahead, Toxicological Sciences, vol. 109, no. 1, pp. 18-23, online at http://toxsci.oxfordjournals.org/cgi/reprint/109/1/18.pdf
Hoffmann, S., Edler, L., Gardner, I., Gribaldo, L., Hartung, T., Klein, C., Liebsch, M., Sauerland, S., Schechtman, L., Stammati, A. and Nikolaidis, E. (2008a) Points of Reference in the Validation Process, The Report and Recommendations of ECVAM Workshop 66a, Alternatives to Laboratory Animals vol. 36, pp. 343-352, downloadable from
http://www.frame.org.uk/atla_article.php?art_id=1084&abstract=true
Hoffman, S., Gallegos Saliner, A., Patlewica, G., Eskes, C., Zuang, V. and Worth, A.P. (2008b) A Feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals, Toxicology Letters, vol. 180, pp. 9-20, abstract online at http://www.ncbi.nlm.nih.gov/pubmed/18585875
van der Worp, H.B., Howells, D.W., Sena, E.S., Porritt, M.J., Rewell. S.,O'Collins, V. and Macleod, M.R. (2010) Can Animal Models of Disease Reliably Inform Human Studies? Public Library of Science Medicinevol. 7, Issue 3, e1000245, online at http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000245