Very noticeable improvements in brain fog using Dr Greg Russell-Jones's transdermal B12 oils (which provide a similar dose to B12 injections)
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Hip
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I found the B12 oils, which provide a systemic B12 dose equivalent to an injection, mainly helped my brain fog, but not other ME/CFS symptoms.
Before ME/CFS, I used to work as a computer programmer. But the brain fog of ME/CFS normally prevents me from doing any coding. However, I found that once I started taking B12 oils once weekly, my ability to program returned to an extent, and I was able to start some computer programming projects at home (just for my own amusement). So this is an objective demonstration that the B12 improved my brain fog.
I may not have noticed these cognitive benefits of B12 oils had it not been for my ability to program returning, and testing this by starting some coding projects. It's good to pit yourself against a difficult cognitive task like this, to see if your performance at the task increases with B12. That way you can objectively measure any improvement.
Thanks Hip. That is pretty clear.
Reaction to the oils seems to be a mixed bag. I have made no inroads on CFS after 18 months. Others say differently.
I'm presently trying the carnivore diet for the CFS, as there are quite a few success stories there...
Artemisia
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I'm selling my new unopened oils from Dr Greg Russell Jones (B12, Iodine, Selenium and Molybdenum). I'm in the US.
See post here
https://forums.phoenixrising.me/thr...russell-jones-supplements.92194/#post-2461937
See post here
https://forums.phoenixrising.me/thr...russell-jones-supplements.92194/#post-2461937
Florida Guy
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I just ordered the Adenosyl/methyl B12 from that doc in oz. If it works for 5 years that will be a success for sure.
Artemisia, I may take you up on it but I have to try it first to see if it works for me. So if you still have it later on I will get back with you
People talk about potassium, instead of pills get a container of salt substitute from the grocery store. Its potassium chloride and tastes almost exactly like sodium chloride (salt)
Another thing I'm going to try is selenium
Artemisia, I may take you up on it but I have to try it first to see if it works for me. So if you still have it later on I will get back with you
People talk about potassium, instead of pills get a container of salt substitute from the grocery store. Its potassium chloride and tastes almost exactly like sodium chloride (salt)
Another thing I'm going to try is selenium
Florida Guy
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Ok it didn't work for me. I got the shipment last week and started taking it in the morning. All I noticed was that my sleep progressively got worse and on the fourth day I don't think I slept at all at night. I stopped using it then. Other than the sleep I didn't feel bad, the few days afterward I felt better, maybe the next day glow from not sleeping? I also felt colder even though I turned up the temps a couple degrees.
You have to expect a few failures along the way. I've found lots of things that helped me over the decades by trying many things. Many didn't work and I lost some money but I'm way better off for trying. I found things the doctor will never tell you. I mention it and they never heard of it or say oh that thing. They knew but would not tell you
Rather than let it go to waste, I plan to donate it. I hope to find someone who has tried it and had good results but hesitates to get more because of the cost. If you are interested, reply to this thread and tell us about your experience with it and say what state you are in. Its so expensive to ship overseas. They soaked me about $30 postage on a small lightweight object.
I may wait a week and pick one, maybe sooner or later depending on the response. If no one is interested I will make a separate thread to offer it. It will not cost you a cent not even for postage. It cost me $80 to order that one thing from the doc.
You have to expect a few failures along the way. I've found lots of things that helped me over the decades by trying many things. Many didn't work and I lost some money but I'm way better off for trying. I found things the doctor will never tell you. I mention it and they never heard of it or say oh that thing. They knew but would not tell you
Rather than let it go to waste, I plan to donate it. I hope to find someone who has tried it and had good results but hesitates to get more because of the cost. If you are interested, reply to this thread and tell us about your experience with it and say what state you are in. Its so expensive to ship overseas. They soaked me about $30 postage on a small lightweight object.
I may wait a week and pick one, maybe sooner or later depending on the response. If no one is interested I will make a separate thread to offer it. It will not cost you a cent not even for postage. It cost me $80 to order that one thing from the doc.
Florida Guy
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The way it came was in a small silver cylinder. You aim the little hole at yourself, and press down on the top which causes a drop of red liquid to squirt on you and you can move it around with your finger. You then absorb it during the day. I see people talk about getting b12 shots, this is a way to get a large dose without injection. I've used 4 sprays and they say you get 60 per unit.
My body battery has been in the 20's waking up ever since I started trying it. I don't feel bad, kind of tired today but my mood is fine. If it didn't mess up my sleep I'd keep taking it. What works for one often doesn't work for the next but might for someone else. I didn't want to bother with asking for money since the recipient might need the money more than I do. Now, hopefully it will do someone some good. Post here if interested
My body battery has been in the 20's waking up ever since I started trying it. I don't feel bad, kind of tired today but my mood is fine. If it didn't mess up my sleep I'd keep taking it. What works for one often doesn't work for the next but might for someone else. I didn't want to bother with asking for money since the recipient might need the money more than I do. Now, hopefully it will do someone some good. Post here if interested
Jadzhia
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@Florida Guy it may not have worked for you because you are deficient in B2. Greg is most insistent that you need to be replete in B2 before using B12 oil. That may be the issue for you?
Florida Guy
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Anything is possible but I take a B complex each day. On the label it says riboflavin 22mg, 1692% of daily requirement. So it seems unlikely to be a lack of b2
We already know that what works for some does not work for others. Its good that many people have found some benefit from b12 but not all are going to respond the same way. If it didn't bother my sleep it might have ended up having a good effect but I could not get past the insomnia
Jadzhia
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According to Greg taking B1 (which I presume is in your B complex) will increase the need for B2. He always recommends taking in excess of the daily requirement of B2 so that your urine is always bright yellow!
Artemisia
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So what does it mean that your body battery was in the 20s? What was it before using the B12 oil?
Greg has a protocol here:
https://b12oils.com/rnb.htm
Florida Guy
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It was in the 50s in the morning previously. I did have a couple days at least in which it went into the 90s by morning but it seems to get lower and lower each week. It was up to 27 this morning, was better than previous mornings but by end of day its 10 or below. I feel ok, a little tired but I get a good nights sleep and the bb says 23 or something. Its not too accurate, soon as I get something better I will discard it.
Yes, I read that. According to the bottle, I'm getting about 17 times the recommended amount of b2 per day so that should be enough. It might be good to take iodide supps.
I have started with the b12 oil, rubbing it on the belly. After 3 days I get more energy and a lot of benefits. One disadvantage I have is the increase of histamine. I cannot sleep in the night (very awake feeling). I have to take an anti-histamine.
Does someone have any tips to encounter the raise in histamine after intake of the oil Adenosyl/Methyl B12? Thanks.
Does someone have any tips to encounter the raise in histamine after intake of the oil Adenosyl/Methyl B12? Thanks.
You may be low in methionine.
People forget that the HNMT enzyme, which breaks down histamine, requires not only b12 and b2 -- and some say folate -- but also methionine. Even Dr. Ben Lynch, who was early on the methylation bandwagon, finally admitted around 2015 or so, that some people may need supplemental methionine, at least for awhile, to bring down histamine levels.
Thanks Danny! Great tip, I know about methionine, but I actually forgot about it. Didn't knew that it plays a role in the HNMT enzyme.
I do know that choline also helps a bit (https://www.geneticlifehacks.com/high-histamine-and-methylation-mthfr-defects/). But after a while choline gave other reactions.
Oh I read that HNMT uses SAM-E to deactivate histamine.
High SAH levels block the HNMT enzyme.
Do I understand it correctly that it's advisable to take methionine before intake of b12? So that the HNMT enzyme can do his job when the b12 raises histamine?
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Well, I'm not a doctor, but some people just stop b12 or methylfolate for awhile, and take methionine by itself. It does convert to homocysteine, so I believe one will eventually need some b12.
Here's an old post on Lynch's site as an example. Look for 'Sero's comment (I disagree though w/Walsh's 'overmethylator/undermethylator' stuff. It's too black and white, but no doubt one's methylation can be over-driven or under-driven for periods. It would be interesting to find out if Sero ever went back on 'some' b12. Also it sounds like he was taking a LOT of extra things, so it's hard to tell if it was caused by too much b12 or folate or (fill in the blank) -- but, having said that, methionine clearly helped him bring down his histamine levels.
p.s. Also note how Lynch pushes back a bit on his comment, but a couple years later added methionine to his list of options if one was having a bad reaction to methylb12 or methylfolate.
From 2011:
https://mthfr.net/taking-folate-and-feeling-badly-methylation-requires-balance/2011/11/15/
Thanks!
I found a supplement that works for me, it's organic Grass Fed Beef Kidney. This supplements contains all the cofactors and also a great form of iron ; heme iron.
It lowers the histamine load (probably because of the DAO) which solves the high histamine issue which I had, and also the B12 oil works far better in terms of energy and overall feeling. This proves that I am low in one (or more) of the cofactors.
Beef kidney supplement contain the following nutrients:
Vitamin A
Vitamin B2 (riboflavin)
Vitamin B3 (niacin)
Vitamin B5 (pantothenic acid)
Vitamin B6
Vitamin B9 (folate)
Vitamin B12
Selenium
Bioavailable heme iron
The enzyme diamine oxidase (DAO)
Kidney-specific peptides, cofactors and enzymes.
What works for me:
Day 1: I take 3 sprays of B12 oil + this day I take potassium powder and in the evening magnesium glycinate.
Day 2: In the afternoon I take 2 capsules of grass fed beef kidney. In the evening before sleep I take a B1 supplement.
Day 3: Got some detox reactions, but it's doable but this is the day that I must rest more.
Day 4-6: The B12 kicks in; a lot of energy and overall good feeling.
Jadzhia
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@jason30 Would that be the Ancestral Grass Fed Beef Kidney supplement? I may buy some as I have histamine intolerance I can't seem to shift, plus low ferritin.
It looks the same as the Ancestral one (also the design and colours), but it say that it's from Nordic Kings;
It's a different company though https://nordickings.se/