• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Methylation, B12, Glutathione, etc.

Some patients have symptoms consistent with a deficiency of methyl donors such as SAMe/AdoMet, either localized to brain regions or elsewhere. Other patients report strange reactions with B vitamins, especially B12 or folate, but without any obvious explanation. This is the place to discuss B vitamins, methyl donors, glutathione, etc.