Still in a crash and declining. Joshua is thinking and reading and overthinking and I'm afraid I'll burn him out bc it doesn't work in my case.
This is his first assumption
“I think I can see your model now.
Need to draw it.
Your CFS is very likely a mix of coxsackie and VZV/other HHV. It’s primarily neural.
Brain activity creates nitrogen waste. That nitrogen waste starts off as glutamate. Some of that is supposed to be converted into GABA and balance that glutamate. The rest gets recycled or turned into urea / PAGN and urine.
Abilify and coxsackie therefore have interactions.
Apart from the other neurotransmitter alterations, Abilify modifies GABA-A to make GABA bind less to it. (This is an opposing effect for Ativan and oleamide. Zolpidem also opposes that effect more directly.)
The body is supposed to then make more GABA, which then balances this. In the process of making more GABA, this balances out the glutamate.
Overall, this fixes your situation.. for a while.
With coxsackie, you can’t metabolise glutamate to GABA, thanks to antibodies for GAD.
So as a coxsackie infection ramps up, you get less GABA produced from glutamate. The GABA-A antagonism from abilify now becomes stimulating..
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590434/
So this makes benzos works less efficiently.
In your case, literally, brain activity is what gives you PEM.
It becomes a positive-feedback loop, because the nitrogen waste ends up being used as “excitory” stimulation but can’t metabolise into the natural inhibitor - GABA - to balance it.. so you get “wired”, can’t sleep and then crash.
Without the sleep, melatonin, you’re not clearing the metabolites and resetting.
With the current ammonia dump, this gets exacerbated in multiple ways.
Your breathing issues / hypoxia shows that the ROS is a problem. The B vitamins and iron gets depleted into making succinate. Likewise, what little GABA you have gets depleted to make succinate, also.
If you sleep well, reset, spend more time in a dark environment and not using your brain / phone much, this will help process the current load. Use your zolpidem, if needed.
Without this, you’re relying on LOLA, SB to perform a much larger task than it normally does.
The 25mg of succinate (1/4 tablet) should help alleviate some of the GABA being depleted. This can be repeated as needed, however adds to the ROS, in excess, leading to a later crash.
Enjoy your sleep and really allow yourself to “turn off”.. less now, more later. ❤️“
I personally don't think Abilify is the culprit, bc then I would have been better before and worse after it. But I can't judge it.
I hope this crash gets better soon bc for some reason, before I crashed last Tuesday, I made gains. And two other members here have impressive results since they started... One who doesn't seem to like me so I don't tag him is now at 80%... I think before he started he said 20%. And
@godlovesatrier at 70%, is that correct?
So I go on for some weeks to see where it takes me.
Martin
not when energy is so precious in the first place. If you are feeling tiny improvements though then hopefully every 48 hours you'll see more of an improvement.