andyguitar
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Here's an idea to ponder....... ME/CFS is caused by dysfunction of the Hypothalamus. Nothing else.
is not inflammation at all. Just temperature abnormalities, thats all.
Also the "Neuroinflammation" that has been suggested by some studies, ie Jared Younger, is not inflammation at all. Just temperature abnormalities, thats all.
since molecules that are warmer, vibrate more...they take up more space, therefore we'd call that inflammed. And so the tissue is a bit swollen if its one degree hotter- its seems to me.
so I don't understand how one can say- the tissue is not inflamed when its temperature is higher.
Yep take your point. But if you were out in the sun and your skin warmed up a bit that would'nt mean it had got inflammed. If you got sunburn it would. So a rise in tissue temperature does not equal inflammation. Depends how high the rise is. Two other points I should drop in. If it was inflammation in the brain how come anti-inflammatories are of little or no help? And if there was a state of chronic inflammation that lasted years (and in some cases decades) how could anyone recover and not sustain lasting brain damage?so I don't understand how one can say- the tissue is not inflamed when its temperature is higher.
The tissue also feels hotter because of the increased metabolism of inflammation.
So a rise in tissue temperature does not equal inflammation.
If it was inflammation in the brain how come anti-inflammatories are of little or no help? And if there was a state of chronic inflammation that lasted years (and in some cases decades) how could anyone recover and not sustain lasting brain damage?
And if there was a state of chronic inflammation that lasted years (and in some cases decades) how could anyone recover and not sustain lasting brain damage?
Quite true. Unfortunately some researchers use the term "neuroinflammation" as if it were a synonym for "neurological inflammation", which is not at all what the 2004 definition intended.
If you're interested in hearing about real neuroinflammation, see this post:
https://forums.phoenixrising.me/thr...n-in-me-subcortical-brain.80923/#post-2289868
Hope this helps.
But the benefits dont seem to last. Which suggests to me that the benefit is from the placebo response.And some patients do indeed report some help from anti-inflammatories:
Particularly if there is no neuroinflammation to treat. Just temperature abnormalities. Which is not to say that those abnormalities cant cause symptoms. It's more a case of how they cause symptoms and what to do about it.To me that may point towards the suspicion that treating neuroinflammation itself might unfortunately not lead us very far.
The million dollar question is if this neuroinflammation is somehow self-fueling or if it's a protective mechanism of the brain against a greater threat, like a pathogen.
To me that may point towards the suspicion that treating neuroinflammation itself might unfortunately not lead us very far.
I have a question, where does “hypophysitis” (inflammation of the pituitary) fit in with this topic? Is it considered temporary neuroinflammation that does not cause permanent damage to the brain or to the endocrine system (meaning to the hormones that are regulated by the pituitary like ACTH, TSH, etc). Thanks!
The pituitary gland, also known as the hypophysis, is a neuroendocrine gland. This means it is directly connected to the brain, but it is not part of the brain. So it is not protected by the blood-brain barrier, and is probably subject to inflammatory damage, but may be able to regenerate itself somewhat.
However, anyone who has been diagnosed with an "empty sella" on a brain MRI, indicating a shrunken pituitary gland, knows that it doesn't regenerate itself that fast...
Hope this helps
Particularly if there is no neuroinflammation to treat. Just temperature abnormalities. Which is not to say that those abnormalities cant cause symptoms. It's more a case of how they cause symptoms and what to do about it.
I get angiodema-type symptoms in all the tissue thats near by central brain.