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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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And for anyone interested in a review of research into the Hypothalamic-Pituitary-Adrenal Axis in ME/cfs, there is the 2013 review by Cara Tomas, Julia Newton, and Stuart Watson:
A Review of Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome (Tomas, Newton, & Watson, 2013)
what's causing the energy crisis?
While I'm not well-versed in it, in the migraine pathophysiology literature, there is the concept of "neurogenic inflammation". And for some reason in that setting, nobody seems to baulk at all about the use of the word inflammation, as they do in ME. It seems pretty well accepted that migraine causes a nasty soup of inflammatory molecules to be released into spaces of the brain and can cause often severe symptoms, to the point where it can even mimic aseptic meningitis.Quite true. Unfortunately some researchers use the term "neuroinflammation" as if it were a synonym for "neurological inflammation", which is not at all what the 2004 definition intended.
in the migraine pathophysiology literature, there is the concept of "neurogenic inflammation".
It seems pretty well accepted that migraine causes a nasty soup of inflammatory molecules to be released into spaces of the brain
it's much harder to get people to accept the fact that neuroinflammation can cause neurological symptoms such as migraine...
Most anti-inflammatories are designed for classical inflammation, not for neuroinflammation. And some patients do indeed report some help from anti-inflammatories:
Note that neuroinflammation can last for years without permanent brain damage. This is because evolution has provided protections against such brain damage, such as:
If you think about it, there's a very good reason why evolution discourages inflammatory tissue damage in the brain, but allows it in other tissues. You simply can not regenerate nerve cells like you can regenerate other types of cells. If evolution allowed nerve cells to be destroyed and regenerated so easily, you would continuously be losing the memories stored in those nerve cell connections.
- The nerve cells in the brain can not easily be phagocytosed by macrophages, as easily happens in other tissues.
- Nerve cells are intrinsically resistant to apoptosis.
- The tissue-resident macrophages in the brain work primarily by secreting cytokines that stimulate the interferon pathway inside nerve cells, which is a message to the nerve cell saying "You've got a problem, nerve cell, time to activate your internal intracellular defenses."
Hope this helps.
Are there anti-neuroinflammatories? Is that what migraine meds are?
Since vasopressin is synthesized by the hypothalamus, may I ask if anyone else has had frequent urination as a symptom.
It seems pretty well accepted that migraine causes a nasty soup of inflammatory molecules to be released into spaces of the brain and can cause often severe symptoms, to the point where it can even mimic aseptic meningitis.
It is so frustrating as they still throw old fashioned preventative medications for us to take which have huge side effects and I can never tolerate them.