After reading this article of 2012
It got my attention because you mentioned amisulpride (solian)
I had found it seemed to really help anxiety and mood on a low dose
I was originally put on 200mg but it made me hyper and prolactin issues
I ended up going onto Clozapine (so I could do my engineering course) able to think as has no cognative impairment.
But discovered that it worked much better with amisulpride added but a low dose of about 1/3 of a 50mg pill about 16.5mg which, like you described had an anti-worry and anti-anxiety affect, very marked.
I have very bad anxiety issues and my psychiatrist says the schizophrenia symptoms I get is caused by the anxiety/Wired like stress (he even said I didn’t have schizophrenia as I have never got voices but more like extreme Anhedonia. )
I also have constant tiredness like CFS
On this basis I have tried your other recommendation of the NAG
This had a remarkable affect which had an experience I’ve got from no other medication in reducing my anxiety by a motivation effect.
But I only need half a Jarrow NAG (700mg) but like you said it works on an empty stomach best in morning. If I have a full pill I get over stimulated.
I’m trying the flaxseed oil now with meal in evening but can’t assess if this is doing much at moment.
I’ve done a lot of Reseach into the causes of my illness which is anxiety/schizophrenia symptoms or phychosis.
I know both types of medication work
Antipsychotics and anxiolytics
Gaba meds (Gabapentin/pregabalin),diazepams
And some antidepressants like mirtazapine and phenelzine(Nardil)
Taking any of the above means I only need half the amount of antipsychotics to work.
The antidepressant are a problem as I’m sensitive to seratonin (Make me high and manic)
The gaba med are a problem as they lower my seizure level so have had to come off them at moment.
My theory of the issue I’ve got is overstimulation of the NMDA receptors
and this may be due to
what you said in your other article ‘non standard antianxity treatments’
“The NMDA receptors are overstimulated probably because of the chronic microglial activation
that is found in brain inflammation (microglia form part of the brain's immune system). Glutamate
and quinolinic acid
are produced as a by-product of microglial operation; glutamate will strongly activate the NMDA “receptors, leading to biochemically-created anxiety
New schizophrenia medications are being designed on a glutimate theory of schizophrenia
It’s now known over dopamine activity that was thought to be the cause is wrong. Though dopamine blocking medications did help its thought this was a side affect of the action of these medications.
Quetiapine is an interesting medication as it’s used for all mental illnesses (bipolar mood stabiliser,schizophrenia, anxiety, depression)
Reseach has found it only stays on the dopamine receptor for seconds so it’s not that that’s making it work. It did work when I tried it perfectly with non of the side affects I have got with others (that block dopamine)but unfortunately I was unable to sleep and had bad stomoch reaction so had to abort its use after a week.
My issue if I stop these medications is
1/ get extreme anxiety and wired and hyper vigilant which after 3 days I become exhausted and become ill.
2/ I become rapidly Anhedonic (not able to experience any pleasure)
3/ no interest in food or drink like tea or alcohol
(Part of the Anhedonia) no pleasure can be obtained from anything like favorite foods or drinks or alcohol ( with medication I’m verging on alcoholism so don’t drink anyway)
4/ can’t sleep and have complete sexual disfunction (anhedonia)
5/ become psychotic but not visually or audiary but become mentally confused and thought become paranoid and disordered. Like massive overstimulation (I thought it was over dopamine production)
I believe the problem is caused by the anxiety at its source and I think the anxiety is caused by like what you’ve said “Brain inflammation”and NMDA over stimulation or ‘microglial activation’ but I don’t know what this is yet.
I’ve also had ME/CFS symptoms and had Alice in wonder syndrome as a kid where I was hospitalised for a month (precursor of schizophrenia) this seemed to be caused via a virus
I wouldn’t be suprised if it’s all been caused by an EBV virus like with ME and CFS
If you can give me any other information on your anxiety solutions I would be very grateful and also any information on what you thinks causing it all like the microglial operation?
I’ve suffered for many years now and your NAG idea has made a major difference and is a totally new concept behind what the problem is.
I’ve come to the end of conventional medications having gone through the book BMF A to Z
I’ve not been able to work properly for 20 years due to the side affects of these antipsychotics due to tiredness and lack of motivation etc
I should also mention the origional issue of the schizophrenia was triggered by LSD trip in my 20’s but apart from the brain issue I had all the other type symptoms like anxiety etc before this