I am pleased to hear that you experienced major anti-anxiety benefits from NAG. I still use NAG today as my key anti-anxiety supplement.
I also sometimes suffer from what I believe is mild psychosis-like symptoms. By complete accident, I found one very effective drug for my mild psychosis, which is the diuretic amiloride
, at a dose of 5 mg. Within 2 hours this will noticeable reduce or eliminate the mild psychosis symptoms.
Amiloride often comes in a pill with amiloride 5 mg and hydrochlorothiazide 50 mg, and this is what I take. I buy these pills at the usual prescription-free overseas pharmacies. The only side effect I get is that it makes you go to the toilet more, because amiloride is a diuretic.
For years I was clueless as to why amiloride might help my mild psychosis symptoms; I could not figure out the mechanism. But then I learnt that amiloride has effects on the adenosine receptors, and one theory of schizophrenia is based on these adenosine receptors (amiloride is an allosteric inhibitor of antagonist binding on the A1, A2 and A3 adenosine receptors).
I mention amiloride at the bottom of this post
, which details the various things that reduce my psychosis symptoms. Other effective substances I find for my mild psychosis are: phosphatidylserine
50 mg to 200 mg, high dose vitamin C
3 grams (needs to be taken 3 times daily to maintain effect), N-acetyl glucosamine
Microglia are the main part of the resident immune system in the brain, and when there is brain inflammation, microglia get activated. Unfortunately when microglia become activated, they pump out lots of glutamate as a by-product of their activation. This flood of glutamate in the brain then over-activates the NMDA receptors, and I think this can cause mental symptoms such as anxiety, and probably other mental symptoms too.
The exact mental symptoms may depend on which part of the brain is in an inflammatory state. The amygdala is one of the key areas linked to anxiety, and I think maybe when there is inflammation and microglial activation in the amygdala, this is when one experiences generalized anxiety disorder.
More and more mental health conditions are being linked to brain inflammation (major depression, OCD, schizophrenia, bipolar and anxiety have all been linked to neuroinflammation).
As for why the brain is inflamed, well, inflammation is simply the immune system in an active state. The active state could be caused by a number of things, but an infection is the most common cause of inflammation. So it could be that in many mental health conditions, there is a viral or bacterial infection in the brain, existing at low levels, but triggering chronic inflammation that leads to mental symptoms.
But we also now know that brain inflammation can be triggered (or worsened) by infection or bacterial dysbiosis in the gut. When the vagus nerve senses infection or inflammation in the gut, it signals this information to the brain, and then the brain in turn will then ramp up its own internal inflammation. So by reducing gut inflammation you can in turn reduce brain inflammation.
I found prebiotics
(as well as probiotics) significantly reduced my anxiety levels, and I believe this is because they reduce gut inflammation. Prebiotics are foods that feed the good bacteria in the gut, but starve the bad bacteria which cause inflammation. See this thread
Regarding your anxiety symptoms: I find it important to distinguish between glutamate-driven anxiety, and a similar mental which is overstimulation/agitation. These two mental states can feel quite similar, but I think they have different causes.
The anxiety I treat using supplements like NAG, turmeric, arginine pyroglutamate nasal sprays, etc.
Whereas in my case, the overstimulation/agitation I think is caused by overmethylation, and the usual way to treat overmethylation is with high doses of niacinamide
, a form of vitamin B3. So when I get this overstimulation/agitation mental state, it will take 500 to 1500 mg of niacinamide.
For me the key to distinguishing the generalized anxiety disorder state from the overstimulation/agitation mental state is the agitated feeling. If I feel agitated, then I know I have overstimulation due to overmethylation.