neuroinflammation

  1. Jwarrior77

    The Causes of ME/CFS, POTS, and Chronic Illness - A patients opinion

    This is my opinion on the causes of these illnesses coming from a patient who suffers from these conditions. My opinion is based on my own experience, research from the top scientists studying this, and also other patients such as Jeff Wood, Jen Brea, and others who have contributed a lot of...
  2. mitoMAN

    Anti-Neuroinflammatories: Dapansutrile (OLT1177) + Emapunil

    Dapansutrile (OLT1177) CAS Number 54863-37-5 https://www.hoelzel-biotech.com/de/dcchemicals-molecule-other-dcc-dc20225-100mg-dapansutrile-olt1177.html and Emapunil CAS Number 226954-04-7 https://www.hoelzel-biotech.com/de/medchem-express-inhibitors-other-hy-15527-5mg-emapunil.html two highly...
  3. L

    Can’t or Won’t? Immunometabolic Constraints on Dopaminergic Drive. Treadway MT et al. Trends Cogn Sci. (2019)

    Interesting review of research on the impact of inflammation on the dopamine system as well as a theoretical model and computational method trying to connect it all. Could be a hypothesis as to why Abilify and dopaminergic agents have some partial efficacy in ME, even if it is temporary (so...
  4. L

    Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders (2019) Werry et al

    An interesting read given the past TSPO-PET neuroinflammation studies on ME using first generation [11C]PK-11195 and now more recently second generation [11C]DPA-713, the pros/cons and limitations of these radioligands, and the development of novel third generation ligands. Recent Developments...
  5. L

    An Inflammation-Centric View of Neurological Disease: Beyond the Neuron (2018) Skaper et al

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic...
  6. L

    A systematic review of neurological impairments in myalgic encephalomyelitis/chronic fatigue syndrome using neuroimaging techniques

    This is a pretty well done and thorough review paper, makes for a good reference to find papers you might've read long ago on particular neuroimaging studies of ME. While most, if not all, the neuroimaging studies in ME had fairly small sample sizes (due to abysmal ME funding!) and most used...
  7. stefanosstef

    How I solved my neuroinflammation

    I am posting this because I have a strong feeling that it can help many others.For me neuroinflammation was/is the worst symptom. The manifestation is happening in many ways: Heavy feeling on head, similar to the feeling I have when I'm sick (which is very rare for the past years).A little more...
  8. Pyrrhus

    Neuroinflammation in Long Covid?

    Here's a new, fascinating paper that detected inflammatory cells in the eye in Long Covid patients. Since the optic nerve at the back of the eye is part of the nervous system, and the optic nerve is a major route for drainage of brain lymph, inflammatory cells in the eye is sometimes a marker...
  9. Pyrrhus

    Second study confirms neuroinflammation in ME subcortical brain

    Many of you will remember the landmark Japanese study from 2014 that used PET tracers to detect and image neuroinflammation in the brains of ME patients. Previously, no one had the technology to detect and image neuroinflammation in ME, as standard MRI's are totally unable to detect or image...
  10. Sarah94

    Jarred younger herbal supplements for neuroinflammation

    So I found (on health rising website) this is the list of herbs that Jarred Younger is looking at for potentially reducing neuroinflammation. Have you tried any of them and did they help? Cucurmin Luteolin Resveratol Gastodia Elata Obovotal Inflexin Pipera kadsura Ganoderma lucidum Berberine...
  11. Jackb23

    Research teams find widespread neuroinflammation in the brains of fibromyalgia patients

    PET imaging studies reveal elevated glial activation, correlation with fatigue levels The results from both centers found that glial activation in several regions of the brains of fibromyalgia patients was significantly greater than it was in control participants. Compared to the MGH team's...
  12. Hip

    Completely eliminated my severe anxiety symptoms with three supplements!

    I had hellish, unrelenting generalized anxiety disorder for several years, and, having tried hundreds of supplements (as well as SSRI drugs and TCA drugs) in my frantic efforts to treat it, I recently found 3 supplements that seem to pretty much eliminate my anxiety! • The first and most potent...
  13. Hip

    Non-Standard Anti-Anxiety Treatment

    Brain Inflammation and Anxiety I am posting this in case anyone is interested in the non-standard anti-anxiety approach I used to cure my extremely high levels of anxiety (generalized anxiety disorder). This approach may well help others suffering with anxiety. This protocol may be very useful...