Palmitoylethanolamide (PEA) to deactivate mast cells

Sherpa

Ex-workaholic adrenaline junkie
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Friends,

I have been suffering from an intense mast cell activation flare due to the Moderna Covid vaccine. While researching treatments into MCAS, I came upon an blog talking about how both CBD and PEA (palmitoylethanolamide) reduce mast cell activation. It quotes:

PEA reduces mast cell migration and degranulation and reduces the pathological overactivation of these cells [21]. Mast cells shift from activated immune- to resting phenotypes under influence of PEA.

Applied exogenously, PEA has proven efficacious in mast cell-mediated experimental models of acute and neurogenic inflammation.

Looking into PubMed, I see:
I tried 600mg of PEA yesterday and felt a noticeable improvement from my COVID vax-induced malaise. I was up off the couch and raking leaves and I also felt more optimistic. Excited to try it again today.

MCAS / histamine intolerance sufferers, please share your experiences with PEA in this thread.
 
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What brand of PEA did you use? I had tried Neurobiologix PEA, but it also has resveratrol, which gives me sleep problems. My doctor suggests PEA for pain, but I had never heard of it as helping with mast cell activation. Interesting!
 

Sherpa

Ex-workaholic adrenaline junkie
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Location
USA
I took PEA by Lake Avenue Nutrition, a 3rd-party tested generic brand by iHerb. I also tried PEA chewable tablets by Life Extension but it contained chemical sweeteners that really upset by stomach.

If you read enough reviews, you will see users talking about how it helps their inflammation. Here is a review from a MCAD sufferer.

I am only on my second day, but I feel it may be helping my mast cell flare. It almost certainly helps my TMJ. I am going to try 600mg twice per day.