NEUROINFLAMMATION - ROUND TABLE DISCUSSION

[SWAlexander]

This our First Round Table Discussion on Neurology where leading experts share their experience and research findings/challenges that they face while understanding the whole picture of Long Covid. We discussed how autoantibodies. viral persistance, MAST cell activation, Gut health - all come into play while discussing Neurology.

And, YES I know it is NEUROINFLAMMATION.

Since I take methotrexate, and Hepaxane for Antiphospholipid-Syndrome, many symptoms disappeared. Most of all pressure in the head combined with spinal fluid leakage in the left ear, POTS and brain fog is almost gone. My energy level is now 80% better than a year ago.

 

[SWAlexander]

Related article: "NEUROINFLAMMATION"

Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate
Abstract
Meningeal lymphatics near the cribriform plate undergo lymphangiogenesis during neuroinflammation to drain excess fluid. Here, we hypothesized that lymphangiogenic vessels may acquire an altered phenotype to regulate immunity. Using single-cell RNA sequencing of meningeal lymphatics near the cribriform plate from healthy and experimental autoimmune encephalomyelitis in the C57BL/6 model, we report that neuroinflammation induces the upregulation of genes involved in antigen presentation such as major histocompatibility complex class II, adhesion molecules including vascular cell adhesion protein 1 and immunoregulatory molecules such as programmed cell death 1 ligand 1, where many of these changes are mediated by interferon-γ. The inflamed lymphatics retain CD11c+ cells and CD4 T cells where they capture and present antigen, creating an immunoregulatory niche that represents an underappreciated interface in the regulation of neuroinflammation. We also found discontinuity of the arachnoid membrane near the cribriform plate, which provides unrestricted access to the cerebrospinal fluid. These findings highlight a previously unknown function of local meningeal lymphatics in regulating immunity that has only previously been characterized in draining lymph nodes.
https://www.nature.com/articles/s41590-022-01158-6