orthostatic intolerance

Abstract Introduction: While the diagnosis of postural orthostatic tachycardia syndrome (POTS) is based on heart rate (HR) and blood pressure (BP) criteria, the pathophysiology of POTS is not fully understood as multiple pathophysiological mechanisms have been recognized. Also...

A comment on another thread by @maddietod alerted me to Dr Peter Rowe’s new book: “Living Well with Orthostatic Intolerance: A Guide to Diagnosis and Treatment” https://press.jhu.edu/books/title/53708/living-well-orthostatic-intolerance I thought it would be interesting to have a discussion...

Abstract Following COVID-19 infection, a substantial proportion of patients suffer from persistent symptoms known as Long COVID. Among the main symptoms are fatigue, cognitive dysfunction, muscle weakness and orthostatic intolerance (OI). These symptoms also occur in myalgic...

Hi everyone I know there have been various threads discussing the ins and outs of why BP goes up or down for ME/CFS patients. This thread is for anyone who has found a treatment, whether medication or supplement, that actually improves or removes an increase in BP upon standing. My BP while...

I often see ME/CFS patients that undergo exercise tests to be diagnosed with two problems: orthostatic intolerance (preload failure) and impaired oxygen extraction (mitochondrial dysfunction). They seem to be pretty well connected, but I've never seen anyone explaining which one is driving the...

Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Abstract Background: As complaints of long-haul COVID patients are similar to those of ME/CFS patients and as...

Physiological assessment of orthostatic intolerance in chronic fatigue syndrome Natelson et al, 2022 Abstract Background Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-ME/CFS. We used a 10-min passive vertical lean test as orthostatic challenge-OC...

Another study from van Campen, Rowe, and Visser! Compression Stockings Improve Cardiac Output and Cerebral Blood Flow during Tilt Testing in ME/CFS (van Campen et al., 2021) https://doi.org/10.3390/medicina58010051 Main points: Without compression stockings, patients experienced a 25% drop...

Abstract Background and Objectives: Symptoms and hemodynamic findings during orthostatic stress have been reported in both long-haul COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but little work has directly compared patients from these two groups. To investigate the...

I just read a good overview article covering all the basics of orthostatic intolerance: Common Syndromes of Orthostatic Intolerance (Stewart, 2013) https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3639459/pdf/peds.2012-2610.pdf (or https://dx.doi.org/10.1542/peds.2012-2610) This paper starts...

Orthostatic intolerance: POTS, hypotension and more. Webinar with professor Peter Rowe 19.10.21 Peter Rowe talks about the different types of orthostatic intolerance, and about how to manage and treat OI.

Authors: Virginia Huxley and Scott Kemp Published: July 27 2018 DOI: 10.1007/978-3-319-77932-4_20 PubMed Central link Chapter link (free access) Full book link (pdf, paywall) Abstract The requirements of metabolizing tissue are both continuous and variable; accordingly, the microvasculature...

Published: 23 September 2021 Authors: C. Linda M.C. van Campen, Peter C. Rowe, Frans C. Visser doi: 10.1016/j.cnp.2021.09.001 Highlights Abstract

I will be trying this today and am wondering if flow rate can impact how well it works since I am gathering that some of the benefit may be from baroreceptors in the blood vessels detecting extra pressure....

Natelson BH, Brunjes DL, Mancini D. Chronic Fatigue Syndrome and Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Sep 7;78(10):1056-1067 doi: 10.1016/j.jacc.2021.06.045 PMID: 34474739 Abstract

I woke up this morning, put on my HR monitoring smart watch (been trying to better monitor my HR, for pacing + OI purposes), and realized pretty quickly that today was not going to be a good day - in terms of OI symptoms and a high HR. This has happened a few times before - some days my HR was...

Hi all, Im extremely thirsty all the time and I have to drink a LOT of water, frequent urination. At night I pee nonstop, never wet the bed or even come close. Just the need to go dramatically increases. I have h-eds. Is this a CFS sx? I feel like I have to drink water moving around or...

The Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Joint Hypermobility Show Larger Cerebral Blood Flow Reductions during Orthostatic Stress Testing Than Patients without Hypermobility: A Case Control Study Hypermobility in ME/CFS: effect on cerebral blood flow (van Campen...

Deconditioning does not explain orthostatic intolerance in ME/CFS (van Campen, Rowe, and Visser, 2021) https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02819-0 Excerpt: I thought the title statement should have been obvious to people by now, but apparently not...

It turns out that, after a lifetime of trying to minimize salt, it's really hard to take in enough sodium just through my diet! It's too bad that I find V8 rather nauseating. My doctor suggested salt tabs. When I asked about brands and dosage he just shrugged and said: "Just take whatever...

A new publication by the team of Phillip Joseph, Anne Oaklander, and David Systrom, which I personally find exciting. Insights from Invasive Cardiopulmonary Exercise Testing of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Joseph et al., 2021)...

I haven't been diagnoses with SFN, mainly because i haven't bothered to go to Doc as i have no pain which seems weird. What i do have is numb skin on my ankles so when i shower the sensation of the water on my skin is different to that of the rest of my legs, I also seems to be loosing hair on...

A new publication from Van Campen, Rowe, and Visser on the effect of sitting up in severe ME: https://www.mdpi.com/2227-9032/8/4/394 Earlier this year they published a similar study on the effect of tilting the head in severe ME...

Cardiopulmonary responses to exercise in an individual with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome during long-term treatment with intravenous saline: A case study Article type: Research Article Authors: Davenport, Todd E.*; a; b | Ward, Michael...

Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing C Linda M C van Campen 1 , Peter C Rowe...

I’ve noticed that my mood drops when I’m upright (sitting, standing, doing chores) long enough. I get irritable, anxious and depressed, but when I lie down my mood gets better quickly. I wonder if it has to do with OI and decreased blood flow to the brain. Do you guys experience this symptom? I...

I stumbled upon this Reddit thread today regarding compression pants alleviating POTS: He used Roadbox Men's Compression Pants according to the thread.

Dr.Systrom seems to have quite a success with Mestinon on his patients. I'd be interested to hear what others WHO GOT WORSE on Mestinon found to be helpful. Im also wondering if you are mild/moderate or severe and how onset of ilness was.My naive hope is to find similarities in our group and...

Hey PR - I just had a quick question. My CFS/ME Specialist advised me to take Metoprolol for POTS and also suggested to increase my salt intake to 2-4 grams a day with increased fluids. Specifically she suggested for me to add in electrolyte powder or to add in salt tablets. Does anyone...

A bit late, but I promised to report about Mestinon Trial (@echobravo) My new GP takes M.E. seriously. :thumbsup: Not only that, he allows me to trial Mestinon without going through a specialist which would be the normal route for this kind of off-label medication use. It works well for a...