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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Methylation, B12, Glutathione, etc.

Some patients have symptoms consistent with a deficiency of methyl donors such as SAMe/AdoMet, either localized to brain regions or elsewhere. Other patients report strange reactions with B vitamins, especially B12 or folate, but without any obvious explanation. This is the place to discuss B vitamins, methyl donors, glutathione, etc.
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