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when I get 5mg M-B12 per injection I get tired and feel more poisoned than usual. I usually feel poisoned but dont know why. The most improvement on strength came from folinic acid, but now Im a little concerned about the paraesthesia like feeling in my legs because I dont know where it comes from. .
So if I take TMG I will lower m-B12 synthesis?? And so on I will lower purine synthesis?? But I wonder why is TMG suggested to take? How much is really needed to fix methylation cycle block?
MB12 in DAN! protocol
Just wanted to amend what I said earlier on this thread. I said DAN! docs were prescribing large doses of MB12, but from what I can glean on autism lists, it's actually quite small, 0.6 or 0.3 mg/ml.
I took 15 mg of methyl b12 .. sublinguals .. the other day. I was sick for 2 days afterwards.
Well, that made a lot of sense to me.
I was struggling to understand Fredd's rational for not using glutathione, esp. since don't some of the Alzheimer's folks mix up glutathione and B12 precisely so they can get some glutathionylcobalamin to boost their b12?
It would be nice to nail this all down, because it's tough enough to do these protocols w/out all the apparent contradictions.
Anyway, I'd like to thank you both for the time and effort you've put in. I hope you can work out all the bugs.
No argument here when it comes to being B12 deficient. I am clearly deficient.
I actually was reading your long B12 thread when I popped the last of those 3 5mg methyl B12 pills. Right after i popped the last one, i read about how you advise to cut them in quarters & titrate up.
Timing is everything, right?
Still not convinced that start-up symptoms isn't the same thing as major detox (kidneys hurt like hell the day afterwards...)
Thank you for reiterating your argument against using glut. Tough to make sense of this w/out a scientific rationale to explain it...
I really have got some great value out of your stuff (dosage, brands, response) & I will continue to read it, and see how other folks respond as I try and reconcile it (or not) with what the DAN movement and Amy Yasko and Dick Deth and Rich Van Konyenburg have shared with us.
Thanks rich for this explanation, I wonder what it indicates in my case as I took daily Oh-B12 inj. for over a year and MMA raised !! I guess I have a converting problem or the A-b12 is oxidized faster than it can be synthesized. So how can I check this? How can the b12 converting enzymes be checked. genetic testing? How do are these enzymes/genes called?
How much M-b12 and A-b12 do you think Rich is orally and how much is o.K. per injection?? Are 5mg inj. three times per week too much?
I guess the question is how much active b12 is immedeately distroyed. As the strength of oxidative and nitrosative stress is very different in PWCs.
Hi joopiter, The paraestheisa feeling your getting.....is it like a burning in the legs and feet at night by any chance? The bottoms of my feet are burning at night right before bed usually. I have also experienced the same kind of burning from ABX, NAC, Glutathione, and probably something else I can't remember. A guess is it may be CPN(chlmyadia pneumonia) die off for me.... However, that is only based on what I have read on CPNHELP.org, hard to know. Can you suggest any good, yet easy reading on the methyaltion cycle? I have seen that chart a number of times but don;t have a great grip on chemistry to interpret that.