Today I actually woke up a bit more refreshed as it seemed that charcoal dump did have some kind of lasting benefit to it despite the war in my nervous system on the day of taking it. In fact I may do that once every week as routine maintenance of the toxic load, don't know if it has permanently got anything ancient out of there that was floating around but as long as it keeps things clean and functional enough. I also have some gumweed tea in the cabinet and started drinking that and did better with it today which I made a post on. I might start drinking it every evening around bed time now.
I also started trying to piece together why that glucosamine things went so terribly and why gluco anything appears to be a central part of my condition yet I haven't found anything that makes sense. That was until I saw someone's post stating that viral infection can hijack the glucorticoid system and remembered how my strange reaction to fruit was similar to my intense cognitive PEM, how the glucosamine helped inflammation a lot in the background but also presented in a similar manner up front though was slightly different yet also resulted in profound sickness after, how glucosamine gave a little energy yet resulted in a neuropathy flare I though I'd never recover from, and how that compound from asparagus once gave me a huge boost in energy and functionality while killing other processes all at the same time. After I looked up the glycolysis pathway I found what might be an answer. The hexosamine biosynthesis pathway.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007419/ - A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138107/ - The Hexosamine Biosynthesis Pathway: Regulation and Function
The issue I have with fruits I've isolated to fructose in sufficient amounts I would only get from fruits, the worst fruits for me have the most fructose. Glucose and sucrose don't have this effect. Sucrose is a combination of glucose and fructose but my guts likely don't break those apart properly resulting in higher tolerance to even your average table sugar. What is right after the fructose conversion? Glucosamine. Same general reaction but even more of a disaster as it was like giving a pathogen a nuclear weapon, possibly one of the biggest mistakes I made yet.Cell with good intentions could have been over burdened already and cells with bad intentions just immediately used it as fuel for their journey. They didn't even need to do anything with fructose, I gave them the next step in the process immediately! Over activation of the HBT and Fructose-6-phosphate amidotransferase can rapidly accelerate inflammation and feed pathogens all at the same time and is even expressed in macrophages. In fact the expression of GFAT is so vast and can do so much the results of giving it glucosamine could be so unpredictable that I'm surprised it didn't get worse than it did. Glucoticoids regulate glucose metabolism and main goal in the immune system is to reduce inflammation. Upon eating a lot of baby asparagus the first time I stopped some of the inflammation but the pathogenic load continued to cause dysfunction and further cause problems but the next day when it started to wear off and protective inflammation rose again I felt somewhat better. Indirectly it altered the glycolysis and HBT system too.
This all points towards something hijacking multiple systems and I'd be interested to see the cross linking with other systems but it's probably infinitely complex and impossible to look over in a day because shocking this system essentially shocks every other system too since it plays such a central role in the immune system and energy generation of the body at the same time while being concected to the glucocorticoid receptor. It seems fro mwhat I'm experiencing now it's a viral infection and candidaand/or similar combo meal. For now I'm going to keep at the gunweed tea for a while and I do want to give myself a nicotine trial under the new added gumweed condition alone. I got the D3 in but i'm going to hold off for a while as I'm focusing on this right now and I don't entirely know what the future will look like from what comes out of it right now. I also have the birch bark extract capsules on the way and I'm a bit on the fence about immediately trying them too until I get this sorted out and things are clearer.
I also started trying to piece together why that glucosamine things went so terribly and why gluco anything appears to be a central part of my condition yet I haven't found anything that makes sense. That was until I saw someone's post stating that viral infection can hijack the glucorticoid system and remembered how my strange reaction to fruit was similar to my intense cognitive PEM, how the glucosamine helped inflammation a lot in the background but also presented in a similar manner up front though was slightly different yet also resulted in profound sickness after, how glucosamine gave a little energy yet resulted in a neuropathy flare I though I'd never recover from, and how that compound from asparagus once gave me a huge boost in energy and functionality while killing other processes all at the same time. After I looked up the glycolysis pathway I found what might be an answer. The hexosamine biosynthesis pathway.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007419/ - A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138107/ - The Hexosamine Biosynthesis Pathway: Regulation and Function
The issue I have with fruits I've isolated to fructose in sufficient amounts I would only get from fruits, the worst fruits for me have the most fructose. Glucose and sucrose don't have this effect. Sucrose is a combination of glucose and fructose but my guts likely don't break those apart properly resulting in higher tolerance to even your average table sugar. What is right after the fructose conversion? Glucosamine. Same general reaction but even more of a disaster as it was like giving a pathogen a nuclear weapon, possibly one of the biggest mistakes I made yet.Cell with good intentions could have been over burdened already and cells with bad intentions just immediately used it as fuel for their journey. They didn't even need to do anything with fructose, I gave them the next step in the process immediately! Over activation of the HBT and Fructose-6-phosphate amidotransferase can rapidly accelerate inflammation and feed pathogens all at the same time and is even expressed in macrophages. In fact the expression of GFAT is so vast and can do so much the results of giving it glucosamine could be so unpredictable that I'm surprised it didn't get worse than it did. Glucoticoids regulate glucose metabolism and main goal in the immune system is to reduce inflammation. Upon eating a lot of baby asparagus the first time I stopped some of the inflammation but the pathogenic load continued to cause dysfunction and further cause problems but the next day when it started to wear off and protective inflammation rose again I felt somewhat better. Indirectly it altered the glycolysis and HBT system too.
This all points towards something hijacking multiple systems and I'd be interested to see the cross linking with other systems but it's probably infinitely complex and impossible to look over in a day because shocking this system essentially shocks every other system too since it plays such a central role in the immune system and energy generation of the body at the same time while being concected to the glucocorticoid receptor. It seems fro mwhat I'm experiencing now it's a viral infection and candidaand/or similar combo meal. For now I'm going to keep at the gunweed tea for a while and I do want to give myself a nicotine trial under the new added gumweed condition alone. I got the D3 in but i'm going to hold off for a while as I'm focusing on this right now and I don't entirely know what the future will look like from what comes out of it right now. I also have the birch bark extract capsules on the way and I'm a bit on the fence about immediately trying them too until I get this sorted out and things are clearer.
