drmullin30
Senior Member
- Messages
- 223
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Yes, you need a doctor to order it just like most lab tests. They have a find a doctor feature on their site, or if you are a doctor like your name says, you should be able to order it. The format is easy these days, you can do the entire kit at home with urine, then poking your finger and putting blood on a card. If you use the prepay option, with your doctor will tell you about, it should be about $179.@Learner1 how much does the Metabolomix+ test cost? They won't tell you until you order! WTF! Also can I get this without my doctor because that will be an issue.
if you are a doctor like your name says,
The moderators should be able to help you change your username if you like.Haha no I'm not a doctor my initials are DR and always cause this confusion and I don't know how to change my username.
I'm actually a systems safety and reliability engineer.
Thanks, that's not an inexpensive test so I'll need to think about it. I also have to pay to see my doctor so total costs for me will be close to $500 CDN so I'm not sure I'll pursue that at this point.
Those are fairly useless for troubleshooting mineral imbalances and methylation issues.Life Extension offers blood tests.
Their CBC includes calcium, phosphorus, and more.
They also offer a serum PTH test. ( parathyroid hormone )
Those are fairly useless for troubleshooting mineral imbalances and methylation issues.
Virtually useless when troubleshooting mineral imbalances and vitamin deficiencies, with the exception of possible B12 or folate deficiency, but then you don't know which..Here's what Life Extension offers for a chemistry panel :
https://www.lifeextension.com/lab-t...try-panel-complete-blood-count-cbc-blood-test
All for 35 bucks.
PTH test is 99.00
Poor methylation is associated with liver disease. This test includes complete metabolic panel.
@jhlyon you describe my sudden onset of insomnia exactly. Fredd's clusters of symptoms have not applied to me after 2 months of low and slow methylation--1000 mcg cocktail of B12 forms + 200 mcg folate + multi of cofactors.
Fatigue and sleep have improved 50% until I ran out of folate, but I continued Bs for two weeks until I had a strong onset of insomnia--body tired, brain alert--which feels like an earlier episode of glutamate elevation after too much taurine.
Cutting B12 to 500 immediately reduced the insomnia from onset (all night) to maintenance insomnia (2am to 4am on). Will see if possibly too high levels of B12 clear in the week it takes to refill my folate and then I will restart slowly up to my original ratio.
Don't think electrolytes / potassium are my issue as I have been drinking Trace Minerals like mother's milk.
Unless low potassium can present as insomnia with none of the other more typical hypo symptoms?
Can B12 with inadequate folate lead to insomnia or potassium-induced insomnia w/o elevated heart, twitching etc.? On another thread someone talked about balancing the energy of B12 with calming effects of folate...but there are more threads in which people blame folate for insomnia.
Hi freddd, I got severe insomnia ( can not sleep at all) from second dose of methylcobalamin, like full blown insomnia. Never had any sleep issues.... I tried niacin and niacinamide for a month even on high doses 1000mg, but it did not work at all..... I am still suffering from extreme insomnia.
Hello. Thank you very much for the valuable information. I'm new to this forum, but I've been trying to understand these complex methylation processes for several years.
My health deteriorated critically 2 years ago, there was a sports injury and treatment with antibacterial drugs. At the moment, I feel acute mitochondrial dysfunction, so I ask Freddd and other forum members to suggest their opinion on my symptoms and tests and give advice on recovery. For completeness, I will describe the reactions to some supplements.
The symptoms are the most important in my opinion and the most painful:
1. Permanent constipation. Previously, I never suffered from this, now constipation brings a strong pulling pain in the body. I have to resort to laxatives
2. Pain in the diaphragm, difficulty breathing, according to the results of ultrasound, the right dome of the diaphragm moves worse than the left.
Constant pulling pain in the liver and gallbladder. There are moments as if you don't have the strength to breathe. Oxygen is poorly supplied to organs and tissues.
3. Impossibility of physical exertion. I am now 32 years old, until the age of 30 I was constantly able to endure serious physical exertion. Right away
4. Stopped tolerating gluten, dairy products
5. A strong food and chemical intolerance has formed. Regarding food, I think I react most acutely to histamine products. Activation of mast cells or histamine intolerance is possible.
6. Muscle pain in different parts of the body. Tendon pain. The muscles don't seem to work. Tendon reflexes are weak. Connective tissue problems, ptosis
7. Swelling, especially on the abdomen. Fluid retention is regular, from it pulling pains even more.
8. Interruptions in the work of the heart, arrhythmia
9. Intolerance to products with sulfur content and additives
10. Sometimes muscle spasms are very strong from movements, turns, squats. Basically a spasm in the abdominal muscles.
The tests are the most important (from what I managed to pass during these 2 years):
1. Homozygous mutation MTHFR A1298C(Glu429Ala) C/C
2. Homozygous mutation MTRR gene: Ile22Met (A66G), MET/MET
3. Homocysteine - 7.4
4. Folic acid above the maximum reference values (lack of methylfolate in the cell?)
5. Vitamin B12 at maximum reference values (lack of active forms in the cell?)
6. Copper is very small
7. Lithium - almost at zero
8. Vitamin D - greatly underestimated
Supplements that I tried and the reaction to them (most supplements do not tolerate):
1. Glutathione. Just destroys me and throws me far back. I did droppers, also tried to take liposomal. All the symptoms worsened, especially breathing became difficult, the diaphragm seems to be blocked, the vessels enter into a strong spasm. The only plus is that sleep is being adjusted.
2. Vitamin D. I can not tolerate even 200 IU - again a spasm of the diaphragm and pain and heaviness in the right side, deterioration of the condition.
3. Vitamin C - relatively well tolerated in small doses
4. Omega 3 - not tolerated
5. B2 (in active form) - I can't stand it
6. Molybdenum - somewhat helps to improve breathing after taking sulfur-containing products
7. TMG 500mg - again it is difficult to breathe, spasm in the right side, diaphragm.
8. SAMe - I tolerate well, sleep and mood are improving.
9. Iodine - worsening symptoms , breathing problems , histamine ?
10. Methylcobalamin b12 + adenosylcobalamin b12 sublingually - well tolerated 1/4 tablet from 1000mcg.
Joint reception for a while allows me to breathe without difficulty, the range of the diaphragm increases
11. Folate L-5-MTHF sublingual - at a dose of 200mcg and even less affects sleep negatively. The mood worsens. But I never drank it for more than 7 days. Can't make a start
12. Magnesium is mainly in small quantities
The remaining multiple supplements are usually poorly tolerated, cause complications of symptoms, difficulty breathing, swelling, etc.
Tell me please, how can you get rid of constipation, fluid retention, start to transfer important vitamins, etc.? Every time I thought I was better I rolled back. I tried to drink L-carnitine a year ago without b12, the reaction was very severe. I'm afraid that the symptoms from the diaphragm are frightening, at least for me.
Read the thing several times and then we can discuss it and get it clear. Sounds like you are having really bearable refeeding syndrome.
https://www.quora.com/Has-someone-u..._filter__=all&__nsrc__=1&__snid3__=1808215186
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In general, it seems to me that histamine has become a serious problem for me. My symptoms for many foods and supplements are very similar to the symptoms of mast cell activation. What is your opinion on this? I think this is due to a lack of methylfolate in the cells
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i also have this problem. increasing allergies and intolerances. at this point its really annoying.
did u find any relief or at least a halt in progression?