Freddd
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THE COMPLETE METHYLATION REVIEW
This is new overview towards which I was working with Rich before his sudden death. There were holes in each of our hypotheses, which we both pointed out to each other and which often came down to “insufficient data” and insufficient understanding. I reviewed some of the raw data from Rich’s study, and reanalyzed it, and we discussed the holes therein, how it fit the symptoms questionnaire patterns and the questions thereby raised. I think we both succeeded in keeping each other more on target. I miss our correspondence and discussion. He knew far more biochemistry and such than I do and was much better at finding explanations for things that repeatedly occurred. I’m a data analyst, not a biochemist. On saying that, I must also point out that Rich was not a systems analyst. He did not adapt well to the changing ideas and like many researchers was defending prior works and ideas.
UNRAVALING THE MYSTERY
Sometimes major scientific misunderstanding or non-understanding acquires great standing and unwarranted belief creating a mystery.
The System is Corrupt
“Gentlemen, get this straight. The police are not here to cause disorder. The police are here to preserve disorder.” Mayor Daley, 1968 Democratic convention police riot.
Deficiency vs. Insufficiency - B12 and folate deficiencies manifest in very dose proportionate ways. There are no sharp cutoffs until one gets to 100% needed dose or zero. In the list of the folate deficiency symptoms under many names, some people might have mood effects before they have IBS, some might never have angular cheilitis, but what does happen is that there are several different groupings of symptoms that tend to appear together. There are approximately 4 or 5 layers of symptoms that appear to come on relatively independent of each other in a progressive manner and dependent upon relative deficiencies of the Deadlock Quartet and 7 or so other critical cofactors and even basic essentials.
So in an extreme folate deficiency body wide inflammation would be present with lots of joint and muscle pain, MCS. Allergies and asthma come in somewhere but it can vary. The greater the insufficiency the more symptoms and the worse the symptoms are. While any of the insufficiencies can cause the same symptoms they cause them in different groupings at different rates and extents. It is necessary to remove all the b12 insufficiency symptoms to expose all the remaining methylfolate insufficiency symptoms. That is how it happens in the titrations. Endless words and time has been wasted disagreeing as to “absolute deficiency” vs “functional deficiency” and what it means, if anything, for therapy. The idea of an absolute deficiency in either of these is ridiculous. MeCbl and AdoCbl have dose proportionality in the 1mcg to 10,000 mcg range or more and L-methylfolate has dose proportionate characteristics from 1 to 32,000mcg at least. As the level of folate/b12 function approaches zero the last symptom in the progression is paralysis of the diaphragm or heart failure followed shortly by death. Everything short of that is a summation of successive insufficiencies starting with 1 symptom and increasing up to several hundred symptoms and signs generally before diaphragm paralysis or heart failure and death.
The old idea of “absolute” deficiency was based on low enough levels of b12 to cause Pernicious Anemia. Then other lesser symptoms then were not really deficiency but rather “functional deficiency” caused by some other lack. This was based on CyCbl or HyCbl only partially helping some dozens out of the hundreds of symptoms the active b12s and folate affect. So the 0.01-1% effectiveness of HyCbl and CyCbl, and the poor or even negative effectiveness of folic acid, has skewed the understanding of cobalamins and folate. That whole idea fought against the natural effectiveness of the active AdoCbl, MeCbl and L-methylfolate as some kind of aberration of “forced” healing as opposed to “normal” healing of HyCbl which turns out to be the starvation survival mode.
Instead it now looks like the “fallback starvation” mode of limited healing of HyCbl and CyCbl versus normal fully effective healing of the active natural b12s somehow has become sacrosanct through 60 years of skewed research. The excellent first rate healing of real b12 became the aberration as the abnormal limited starvation mode became “normal”. This is exactly what has happened with blood test results. The normal of red cell MCV < 93 has been displaced as MCV < 100 or even MCV < 102 has become “normal” as acceptance of starvation mode as normal spreads and becomes “normal”. Many other blood measures are also affected and in those the abnormal has become the new “normal”. At the point that deficiency symptoms have taken over test results to the point of making the abnormal test results become normal, the system has been corrupted. The test results ranges as now defined are set to maintain deficiency and illness as the norm. The tests now serve to maintain disorders.
Many other tests, in fact all the ones that might be affected by methylation and ATP availability, are biased now to support a set of chronic deficiency states that have become the norm by invading our food supply. Our biochemistry evolved over hundreds of millions of years. Somewhere very early on in our evolution bacteria started producing MeCbl and/or AdoCbl. Somewhere along the way they became the normal cobalamins for all animal life on this planet, just as hemoglobin (iron based) became the oxygen carrier system in animals. Nature is a tough master. Anything that can’t make it dies. Given 300,000,000 years we could have evolved to use HyCbl or CyCbl if that is what the whole lineage of micro and macro animals had evolved with it. It would have had full effectiveness if we had so evolved. However we didn’t evolve that way. We didn’t have billions and billions die from inability to use it effectively. We didn’t pay that price. However, we are now paying that price, completely unnecessarily at that. We have a significant portion of our population with untreatable chronic diseases.
WHY DON’T HyCbl AND CyCbl WORK WELL?
So when asked why don’t HyCbl and CyCbl work well it’s because they are not what our biochemistry evolved to use over hundreds of millions of years starting before mammals even existed. We did evolve a starvation mode of survival in which some of the previously used cobalamins that had become unusable throwaway forms after MeCbl breaks down or detoxifies cyanide and reclaim them. As with other work around methods it isn’t very effective and it doesn’t provide enough active cobalamins to do any major healing but it is enough to stay alive during a famine or a bad winter. It does require the presence of some reduced amount of each MeCbl, AdoCbl, l-methylfolate and l-carnitine fumarate to provide the needed biochemistry to fuel the conversion, allowing the body to tread water for a while.
WHY ARE THERE ALL THESE COBALAMIN A, B, C, D, ETC DISEASES?
These are the cataloging of all the ways our bodies didn’t evolve to use HyCbl and CyCbl. These gene variations never got culled out of us by disease and death in a natural environment. Those that had these enzymes might survive starvation better as they can use some trace cobalamins, but not enough difference to cull out those that don’t. General starvation isn’t selective enough. So many people don’t have the enzymes needed to transform trace cobalamins that the body creates from MeCbl for special purposes or post use or breakdown products, to recycle them for a workaround for starvation for a while. Some have even suggested that the lethargy of metabolic shutdown (seasonal CFS) achieved by AdoCbl/MeCbl starvation allowed early humans to survive long winters of semi starvation with very low food requirements substituting for true hibernation or winter sleep.
WHY DOESN’T FOLIC ACID WORK WELL FOR EVERYBODY?
When the same questions are asked about folic acid the same answers arise. If it were food it would be “stale” and spoiled. It’s too oxidized. It is to l-methylfolate as flaxseed oil is to linoleum. We never evolved to use that. It’s no wonder that nobody can convert enough folic acid to fulfill all folate requirements. It’s no wonder 20% can’t convert it at all, 30% can convert limited amounts and about 50% can convert up to about 800mcg daily of folic acid which is not as much as the body needs to heal. We never evolved to use it. 60 years of usage since it’s invention hasn’t killed the billions yet that would allow evolution to adapt to folic acid.
WHY DO SOME PEOPLE FIND FOLINIC ACID UNUSABLE?
Folinic acid is another matter. It is the natural folate of most vegetables. It is a handicap not to be able to use vegetable folate but lots of people can survive on the animal form of folate. It is a handicap to not be able to digest milk as an adult. Adults can do fine without milk and cheese. It is a handicap not to be able to utilize gluten, a protein in some grains. There are lots of alternatives to gluten. Milk as an adult food is a recent arrival on the scene. Grain containing gluten as a dietary mainstay is a more recent arrival on the scene. 10,000 years more or less hasn’t been long enough to for humans to fully genetically adjust. However, some populations have evolved to be able to drink milk as adult. Most people in the world can’t digest milk as adults. I “should” be able to digest milk as “should” my ex-wife. We both come from northern long term dairy drinking white folks. Neither of us can do so. Chances are our children won’t be able to either. I miss it but I sure don’t miss the digestive problems. Fortunately gluten gives me no problem at all. On these variables like adult milk and gluten, 10,000 or 20,000 years or whatever isn’t enough for a population to fully adapt. For vegetable folate, even 400,000,000 years hasn’t been long enough for 100%. However, I can use the natural animal form of folate, L-methylfolate or I wouldn’t be alive to write this as can 100% of people. Vegetable folate is an “also” or a biological workaround. However it is amply effective for the majority of persons. Some tribes evolved on high meat diets for a long time and some did not.
In a normal software system after too many generations of changes it becomes unmaintainable and needs to be reconceptualized and redesigned. A college I went to in the 1960s had brand new physics and chemistry buildings both with standard air pressure, humidity and temperature. The only thing not standardized was local gravity. That standardization has NEVER been done in nutrition with all the active natural forms of the vitamins. What we have standardized on are CyCbl , HyCbl and folic acid. We are reaping the results, with all these rapidly increasing neurological, metabolic, neuro-psyc diseases and generally poor health with lots of symptoms and no treatments that actually work. Even worse is that these symptoms and diseases have become the “norm” as these fake vitamins are in many foods. I eat almost no white flour products, no fortified products, no corn syrup, minimal trans-fats and almost no processed foods. I avoid folic acid and CyCbl like the poisons they are to me. Instead I take the natural forms in sufficient quantity to allow my damaged body to function.
Rich’s number one objection to what I first presented was that IT, whatever IT is, was widely happening and could not because of genetic inability to use HyCbl. He placed a lot of emphasis on the vanishingly small percentage of people that have the lettered cobalamin “diseases”; Cobalamin A, Cobalamin B, Cobalamin C and other such diseases. He was partially correct. The lettered diseases are terribly rare and were only invented (recognized) because of CyCbl and HyCbl. In the absence of these two oxidized inactive cobalamins none of these genetic conditions (“diseases”) would have been found. They were found because infants being given formula with CyCbl had failure to thrive. In fact they were starving to death rapidly because of a lack of the MeCbl, AdoCbl and l-methylfolate found in milk (at first) and basically all foods of animal origin that instead had soy milk with corn syrup and inactive oxidized artificial folic acid and CyCbl or HyCbl vitamins instead of the animal based forms.
Carmen Wheatley’s “Giant Gorilla … Adenosylcobalamin …” (free download, don’t miss it http://www.researchgate.net/profile/Carmen_Wheatley/publications/ ) article couldn’t have said it more plainly. It looks like the NATURAL effectiveness of the natural active forms of cobalamin is radically greater than HyCbl and CyCbl (I’ve said 100 to 10,000 times more effective for 9 years) and that the body being able to use HyCbl at all is a starvation workaround. It is the ALTERNATE pathway when starving to death that will barely maintain life but not health. Cobalamin A, B, C, D, E, etc are highly technical deficiency diseases lacking enzymes to convert one form to another, that only become visible when inactive cobalamins are substituted for active ones during man-made starvation of active cobalamins. There is a deadlock here too, as ATP is absolutely needed to power those enzymes. To make the ATP one MUST have some working AdoCbl and l-carnitine fumarate in the mitochondria already and some methylation capacity (MeCbl and l-methylfolate). In other words, those lettered diseases are also the result of the laboratory mistake that said that CyCbl was the real thing. In a “natural” environment they almost don’t exist. The only ones that do exist naturally relate to interconversion between AdoCbl and MeCbl and eating a mix makes that unimportant. Further they, the inactive forms, can only be converted to active forms if one has sufficient of the active forms to make the enzymes and energy for the conversion in the first place.
We never went through the culling that would evolve us to use folic acid, CyCbl and HyCbl because they don’t exist in natural foods. All we ever achieved is a workaround pathway that salvages a minimum amount of usable cobalamins from the otherwise unusable cobalamins when the supply of fresh cobalamins runs out. We are being culled right now. MS, ME, FMS, CFS, Parkinson’s, Alzheimer’s, Autism, Supra nuclear Palsy, IBS, Neuropathies, Subacute combined degeneration, reproduction failure, congestive heart failure, endothelial inflammation and failure, early death from a multitude of causes, all part of these manmade mystery diseases. They are the result of systematic starvation of the body of three absolutely needed vitamins with <1% effective oxidized (spoiled) pseudo vitamins substituted. This is the 21st century equivalent of Scurvy, Pellagra and Beriberi all rolled into one. Food when it is oxidized becomes spoiled, stale and rancid, not supporting health. Folic acid, CyCbl and HyCbl are all forms of concentrated food (vitamins ) that are oxidized, spoiled, rancid, stale and not supporting of health. Would you eat linoleum instead of fresh salad oil? It’s just oxidized edible oil. Sure, it keeps better but is it nutritionally the same? How about a nice meal of tanned leather instead whole roast pig? The leather keeps lots longer. But it isn’t the same when it comes to eating.
Our children are suffering tremendously with these manmade diseases. I grew up in the 50s and 60s. I NEVER even heard of or saw a single child with ADD or AHDH or any of these many neurological disorders of children. Yes, we had Osgood Schlatter’s disease and Mono, mumps, scarlet fever, measles and chicken pox, anorexia was very rare and nobody at all had CFS or FMS. I see it all the time in pre-teens and teens now. There were NO children “stimming”. Now it can’t be avoided. You just didn’t see it then. I was in a lot of homes and saw all the children. Autism was extremely rare, not rarely recognized. Parkinson’s was rare. MS was rare. All these neurological diseases were rare. And don’t tell me it was because people died so much younger. Life expectancy at 65 in 1937 before antibiotics was just 3-4 years less than it is today, with lots of smokers at that time. It was life expectancy before age 5 or 10 that changed mostly. Now it is possible that all of us sick folks were the ones that would have died without childhood antibiotics and so we are being culled later. However, it appears more likely that the damage to the immune system that made us sick and needing antibiotics originally was caused by paradoxical folate deficiency to folinic acid which now expanded to include folic acid and CyCbl and/or HyCbl in ALL formulas and fortified cereals etc.
So, chasing down all these cobalamin “diseases” is fruitless, a waste of money and effort since they don’t exist or don’t matter if everybody gets the real vitamins. Rich convinced me that I was barking up the wrong tree theoretically (not pragmatically, 2 different things as I was getting excellent results, I GOT WELL). If these genetic variations are too rare to be making so many people so sick then what is doing so? That answer is complicated.
Rich was correct in calling what he was looking at “partial methylation block”. It is a partial block. Rich was looking at only the lowest level of the blockage, the folate-Cbl level. This is the most visible level of DNA-RNA transactions using MeCbl and l-methylfolate. The body, using the active transport system of transcobalamin has its own triage methods for supplying MeCbl and AdoCbl to various tissues. It can transport a few 10s of mcg per day to various tissues which is far more than the typical 5mcg or so eaten and absorbed. Rich said that using huge doses of MeCbl was “forcing” activity. Along the way he did say that he didn’t think that 1mg of oral or sublingual MeCbl was huge or forcing. However since MeCbl has a rather dose proportionate response range but was unmapped, it was some vague amount like 10mg injections. There were all sorts of wild ideas of how the active b12 protocol “ought” to be applied. So now, Wheatley has identified the “radically” more effective AdoCbl as the natural normal path and the HyCbl path as a barely working workaround for starvation in the control of inflammation.
end part 1
This is new overview towards which I was working with Rich before his sudden death. There were holes in each of our hypotheses, which we both pointed out to each other and which often came down to “insufficient data” and insufficient understanding. I reviewed some of the raw data from Rich’s study, and reanalyzed it, and we discussed the holes therein, how it fit the symptoms questionnaire patterns and the questions thereby raised. I think we both succeeded in keeping each other more on target. I miss our correspondence and discussion. He knew far more biochemistry and such than I do and was much better at finding explanations for things that repeatedly occurred. I’m a data analyst, not a biochemist. On saying that, I must also point out that Rich was not a systems analyst. He did not adapt well to the changing ideas and like many researchers was defending prior works and ideas.
UNRAVALING THE MYSTERY
Sometimes major scientific misunderstanding or non-understanding acquires great standing and unwarranted belief creating a mystery.
The System is Corrupt
“Gentlemen, get this straight. The police are not here to cause disorder. The police are here to preserve disorder.” Mayor Daley, 1968 Democratic convention police riot.
Deficiency vs. Insufficiency - B12 and folate deficiencies manifest in very dose proportionate ways. There are no sharp cutoffs until one gets to 100% needed dose or zero. In the list of the folate deficiency symptoms under many names, some people might have mood effects before they have IBS, some might never have angular cheilitis, but what does happen is that there are several different groupings of symptoms that tend to appear together. There are approximately 4 or 5 layers of symptoms that appear to come on relatively independent of each other in a progressive manner and dependent upon relative deficiencies of the Deadlock Quartet and 7 or so other critical cofactors and even basic essentials.
So in an extreme folate deficiency body wide inflammation would be present with lots of joint and muscle pain, MCS. Allergies and asthma come in somewhere but it can vary. The greater the insufficiency the more symptoms and the worse the symptoms are. While any of the insufficiencies can cause the same symptoms they cause them in different groupings at different rates and extents. It is necessary to remove all the b12 insufficiency symptoms to expose all the remaining methylfolate insufficiency symptoms. That is how it happens in the titrations. Endless words and time has been wasted disagreeing as to “absolute deficiency” vs “functional deficiency” and what it means, if anything, for therapy. The idea of an absolute deficiency in either of these is ridiculous. MeCbl and AdoCbl have dose proportionality in the 1mcg to 10,000 mcg range or more and L-methylfolate has dose proportionate characteristics from 1 to 32,000mcg at least. As the level of folate/b12 function approaches zero the last symptom in the progression is paralysis of the diaphragm or heart failure followed shortly by death. Everything short of that is a summation of successive insufficiencies starting with 1 symptom and increasing up to several hundred symptoms and signs generally before diaphragm paralysis or heart failure and death.
The old idea of “absolute” deficiency was based on low enough levels of b12 to cause Pernicious Anemia. Then other lesser symptoms then were not really deficiency but rather “functional deficiency” caused by some other lack. This was based on CyCbl or HyCbl only partially helping some dozens out of the hundreds of symptoms the active b12s and folate affect. So the 0.01-1% effectiveness of HyCbl and CyCbl, and the poor or even negative effectiveness of folic acid, has skewed the understanding of cobalamins and folate. That whole idea fought against the natural effectiveness of the active AdoCbl, MeCbl and L-methylfolate as some kind of aberration of “forced” healing as opposed to “normal” healing of HyCbl which turns out to be the starvation survival mode.
Instead it now looks like the “fallback starvation” mode of limited healing of HyCbl and CyCbl versus normal fully effective healing of the active natural b12s somehow has become sacrosanct through 60 years of skewed research. The excellent first rate healing of real b12 became the aberration as the abnormal limited starvation mode became “normal”. This is exactly what has happened with blood test results. The normal of red cell MCV < 93 has been displaced as MCV < 100 or even MCV < 102 has become “normal” as acceptance of starvation mode as normal spreads and becomes “normal”. Many other blood measures are also affected and in those the abnormal has become the new “normal”. At the point that deficiency symptoms have taken over test results to the point of making the abnormal test results become normal, the system has been corrupted. The test results ranges as now defined are set to maintain deficiency and illness as the norm. The tests now serve to maintain disorders.
Many other tests, in fact all the ones that might be affected by methylation and ATP availability, are biased now to support a set of chronic deficiency states that have become the norm by invading our food supply. Our biochemistry evolved over hundreds of millions of years. Somewhere very early on in our evolution bacteria started producing MeCbl and/or AdoCbl. Somewhere along the way they became the normal cobalamins for all animal life on this planet, just as hemoglobin (iron based) became the oxygen carrier system in animals. Nature is a tough master. Anything that can’t make it dies. Given 300,000,000 years we could have evolved to use HyCbl or CyCbl if that is what the whole lineage of micro and macro animals had evolved with it. It would have had full effectiveness if we had so evolved. However we didn’t evolve that way. We didn’t have billions and billions die from inability to use it effectively. We didn’t pay that price. However, we are now paying that price, completely unnecessarily at that. We have a significant portion of our population with untreatable chronic diseases.
WHY DON’T HyCbl AND CyCbl WORK WELL?
So when asked why don’t HyCbl and CyCbl work well it’s because they are not what our biochemistry evolved to use over hundreds of millions of years starting before mammals even existed. We did evolve a starvation mode of survival in which some of the previously used cobalamins that had become unusable throwaway forms after MeCbl breaks down or detoxifies cyanide and reclaim them. As with other work around methods it isn’t very effective and it doesn’t provide enough active cobalamins to do any major healing but it is enough to stay alive during a famine or a bad winter. It does require the presence of some reduced amount of each MeCbl, AdoCbl, l-methylfolate and l-carnitine fumarate to provide the needed biochemistry to fuel the conversion, allowing the body to tread water for a while.
WHY ARE THERE ALL THESE COBALAMIN A, B, C, D, ETC DISEASES?
These are the cataloging of all the ways our bodies didn’t evolve to use HyCbl and CyCbl. These gene variations never got culled out of us by disease and death in a natural environment. Those that had these enzymes might survive starvation better as they can use some trace cobalamins, but not enough difference to cull out those that don’t. General starvation isn’t selective enough. So many people don’t have the enzymes needed to transform trace cobalamins that the body creates from MeCbl for special purposes or post use or breakdown products, to recycle them for a workaround for starvation for a while. Some have even suggested that the lethargy of metabolic shutdown (seasonal CFS) achieved by AdoCbl/MeCbl starvation allowed early humans to survive long winters of semi starvation with very low food requirements substituting for true hibernation or winter sleep.
WHY DOESN’T FOLIC ACID WORK WELL FOR EVERYBODY?
When the same questions are asked about folic acid the same answers arise. If it were food it would be “stale” and spoiled. It’s too oxidized. It is to l-methylfolate as flaxseed oil is to linoleum. We never evolved to use that. It’s no wonder that nobody can convert enough folic acid to fulfill all folate requirements. It’s no wonder 20% can’t convert it at all, 30% can convert limited amounts and about 50% can convert up to about 800mcg daily of folic acid which is not as much as the body needs to heal. We never evolved to use it. 60 years of usage since it’s invention hasn’t killed the billions yet that would allow evolution to adapt to folic acid.
WHY DO SOME PEOPLE FIND FOLINIC ACID UNUSABLE?
Folinic acid is another matter. It is the natural folate of most vegetables. It is a handicap not to be able to use vegetable folate but lots of people can survive on the animal form of folate. It is a handicap to not be able to digest milk as an adult. Adults can do fine without milk and cheese. It is a handicap not to be able to utilize gluten, a protein in some grains. There are lots of alternatives to gluten. Milk as an adult food is a recent arrival on the scene. Grain containing gluten as a dietary mainstay is a more recent arrival on the scene. 10,000 years more or less hasn’t been long enough to for humans to fully genetically adjust. However, some populations have evolved to be able to drink milk as adult. Most people in the world can’t digest milk as adults. I “should” be able to digest milk as “should” my ex-wife. We both come from northern long term dairy drinking white folks. Neither of us can do so. Chances are our children won’t be able to either. I miss it but I sure don’t miss the digestive problems. Fortunately gluten gives me no problem at all. On these variables like adult milk and gluten, 10,000 or 20,000 years or whatever isn’t enough for a population to fully adapt. For vegetable folate, even 400,000,000 years hasn’t been long enough for 100%. However, I can use the natural animal form of folate, L-methylfolate or I wouldn’t be alive to write this as can 100% of people. Vegetable folate is an “also” or a biological workaround. However it is amply effective for the majority of persons. Some tribes evolved on high meat diets for a long time and some did not.
In a normal software system after too many generations of changes it becomes unmaintainable and needs to be reconceptualized and redesigned. A college I went to in the 1960s had brand new physics and chemistry buildings both with standard air pressure, humidity and temperature. The only thing not standardized was local gravity. That standardization has NEVER been done in nutrition with all the active natural forms of the vitamins. What we have standardized on are CyCbl , HyCbl and folic acid. We are reaping the results, with all these rapidly increasing neurological, metabolic, neuro-psyc diseases and generally poor health with lots of symptoms and no treatments that actually work. Even worse is that these symptoms and diseases have become the “norm” as these fake vitamins are in many foods. I eat almost no white flour products, no fortified products, no corn syrup, minimal trans-fats and almost no processed foods. I avoid folic acid and CyCbl like the poisons they are to me. Instead I take the natural forms in sufficient quantity to allow my damaged body to function.
Rich’s number one objection to what I first presented was that IT, whatever IT is, was widely happening and could not because of genetic inability to use HyCbl. He placed a lot of emphasis on the vanishingly small percentage of people that have the lettered cobalamin “diseases”; Cobalamin A, Cobalamin B, Cobalamin C and other such diseases. He was partially correct. The lettered diseases are terribly rare and were only invented (recognized) because of CyCbl and HyCbl. In the absence of these two oxidized inactive cobalamins none of these genetic conditions (“diseases”) would have been found. They were found because infants being given formula with CyCbl had failure to thrive. In fact they were starving to death rapidly because of a lack of the MeCbl, AdoCbl and l-methylfolate found in milk (at first) and basically all foods of animal origin that instead had soy milk with corn syrup and inactive oxidized artificial folic acid and CyCbl or HyCbl vitamins instead of the animal based forms.
Carmen Wheatley’s “Giant Gorilla … Adenosylcobalamin …” (free download, don’t miss it http://www.researchgate.net/profile/Carmen_Wheatley/publications/ ) article couldn’t have said it more plainly. It looks like the NATURAL effectiveness of the natural active forms of cobalamin is radically greater than HyCbl and CyCbl (I’ve said 100 to 10,000 times more effective for 9 years) and that the body being able to use HyCbl at all is a starvation workaround. It is the ALTERNATE pathway when starving to death that will barely maintain life but not health. Cobalamin A, B, C, D, E, etc are highly technical deficiency diseases lacking enzymes to convert one form to another, that only become visible when inactive cobalamins are substituted for active ones during man-made starvation of active cobalamins. There is a deadlock here too, as ATP is absolutely needed to power those enzymes. To make the ATP one MUST have some working AdoCbl and l-carnitine fumarate in the mitochondria already and some methylation capacity (MeCbl and l-methylfolate). In other words, those lettered diseases are also the result of the laboratory mistake that said that CyCbl was the real thing. In a “natural” environment they almost don’t exist. The only ones that do exist naturally relate to interconversion between AdoCbl and MeCbl and eating a mix makes that unimportant. Further they, the inactive forms, can only be converted to active forms if one has sufficient of the active forms to make the enzymes and energy for the conversion in the first place.
We never went through the culling that would evolve us to use folic acid, CyCbl and HyCbl because they don’t exist in natural foods. All we ever achieved is a workaround pathway that salvages a minimum amount of usable cobalamins from the otherwise unusable cobalamins when the supply of fresh cobalamins runs out. We are being culled right now. MS, ME, FMS, CFS, Parkinson’s, Alzheimer’s, Autism, Supra nuclear Palsy, IBS, Neuropathies, Subacute combined degeneration, reproduction failure, congestive heart failure, endothelial inflammation and failure, early death from a multitude of causes, all part of these manmade mystery diseases. They are the result of systematic starvation of the body of three absolutely needed vitamins with <1% effective oxidized (spoiled) pseudo vitamins substituted. This is the 21st century equivalent of Scurvy, Pellagra and Beriberi all rolled into one. Food when it is oxidized becomes spoiled, stale and rancid, not supporting health. Folic acid, CyCbl and HyCbl are all forms of concentrated food (vitamins ) that are oxidized, spoiled, rancid, stale and not supporting of health. Would you eat linoleum instead of fresh salad oil? It’s just oxidized edible oil. Sure, it keeps better but is it nutritionally the same? How about a nice meal of tanned leather instead whole roast pig? The leather keeps lots longer. But it isn’t the same when it comes to eating.
Our children are suffering tremendously with these manmade diseases. I grew up in the 50s and 60s. I NEVER even heard of or saw a single child with ADD or AHDH or any of these many neurological disorders of children. Yes, we had Osgood Schlatter’s disease and Mono, mumps, scarlet fever, measles and chicken pox, anorexia was very rare and nobody at all had CFS or FMS. I see it all the time in pre-teens and teens now. There were NO children “stimming”. Now it can’t be avoided. You just didn’t see it then. I was in a lot of homes and saw all the children. Autism was extremely rare, not rarely recognized. Parkinson’s was rare. MS was rare. All these neurological diseases were rare. And don’t tell me it was because people died so much younger. Life expectancy at 65 in 1937 before antibiotics was just 3-4 years less than it is today, with lots of smokers at that time. It was life expectancy before age 5 or 10 that changed mostly. Now it is possible that all of us sick folks were the ones that would have died without childhood antibiotics and so we are being culled later. However, it appears more likely that the damage to the immune system that made us sick and needing antibiotics originally was caused by paradoxical folate deficiency to folinic acid which now expanded to include folic acid and CyCbl and/or HyCbl in ALL formulas and fortified cereals etc.
So, chasing down all these cobalamin “diseases” is fruitless, a waste of money and effort since they don’t exist or don’t matter if everybody gets the real vitamins. Rich convinced me that I was barking up the wrong tree theoretically (not pragmatically, 2 different things as I was getting excellent results, I GOT WELL). If these genetic variations are too rare to be making so many people so sick then what is doing so? That answer is complicated.
Rich was correct in calling what he was looking at “partial methylation block”. It is a partial block. Rich was looking at only the lowest level of the blockage, the folate-Cbl level. This is the most visible level of DNA-RNA transactions using MeCbl and l-methylfolate. The body, using the active transport system of transcobalamin has its own triage methods for supplying MeCbl and AdoCbl to various tissues. It can transport a few 10s of mcg per day to various tissues which is far more than the typical 5mcg or so eaten and absorbed. Rich said that using huge doses of MeCbl was “forcing” activity. Along the way he did say that he didn’t think that 1mg of oral or sublingual MeCbl was huge or forcing. However since MeCbl has a rather dose proportionate response range but was unmapped, it was some vague amount like 10mg injections. There were all sorts of wild ideas of how the active b12 protocol “ought” to be applied. So now, Wheatley has identified the “radically” more effective AdoCbl as the natural normal path and the HyCbl path as a barely working workaround for starvation in the control of inflammation.
end part 1
