To anyone else considering prednisone, I second everyone here who has suggested that it could be dangerous since it may allow causative pathogens to proliferate, weakening an already impaired immune response. You might feel better but it's worsening the underlying cause.
I don't know if this is helpful to anyone, but I took telmisartan for about a year to suppress my extremely elevated TGF-beta. (TGF-beta is elevated in many ME patients, it is an anti-inflammatory cytokine which generally suppresses and regulates the immune system, but it is hypothesized to have less effect on Th2 cells than Th1 or Th17).
Interestingly, the telmisartan-induced TGF-beta blockade both worsened my ME and shifted my generally Th1/Th17 dominant cytokine profile to a Th2 profile.
During this time, I felt MUCH better on prednisone, but tapering off (as others have mentioned) caused a major relapse.
After stopping the telmisartan, my symptoms improved. With my TGF-beta high again, and my Th1/Th17 cells reactivated, I had another exacerbation of my ME after a strep infection. This time, I tried a very short trial of a small amount of prednisone, just out of curiosity.
This time, taking prednisone made me feel a lot worse.
So our immune and cytokine profile at the time probably determines whether or not prednisone will make us feel better or worse, but it does not change the underlying disease or make it a "different disease."
Another issue to consider with prednisone is that it generally causes tissues to weaken and thin over time. Thin and fragile (excessively permeable) intestinal walls and blood-brain barriers, depending on who you talk to, are either causative factors, contributing factors, or symptoms of ME/CFS pathology.
But any way you look at it, you don't want a thin, leaky gut, BBB, or any other membrane when you have ME.