The creation and facilitated differentiation of T-regs orchestrates what is largely an anti-inflammatory and immune suppressing role, and these immune cells have also been found to exert control over many parts of our own metabolisms. T-reg proliferation, therefore, modulates an energetic response. Treg's themselves have also recently been proven to promote microbial diversity, which is widely correlated with better health. Treg accumulation like other immune cells mediates a condition and is a restorative process of sorts. Should we concentrate on organisms known to positively regulate this environment, well I'm not sure, but these microbes are generally part of a normal, healthy microbiome and have proven to confer benefits.
The study you referenced identifies some of those clostridal organisms involved in the biosynthesis of butyrate, which of course, is a microbial metabolite, and one that positively regulates the differentiation of FoxP3 cells in the colon. We benefit from the creation of these specialized cells in very specific ways related to minimizing the effects of endotoxins, and the organisms that have proven to be necessary for Treg homeostasis, actually all appear to have vital roles in this process. While Tregs are not only important for regulating the host response to gram negative endotoxins, this appears to be the central feature.
In addition to butyrate availability in the colon, we also know that the carbohydrate outer cell walls of some organisms in our GIT (Bacteroides fragilis) induce the differentiation of CD4 T cells into Foxp3 Tregs. These cells produce IL-10. I suspect that this species polysaccharide A, cell walls which is not endotoxic, serves an immunomodulary role, like butyrate, and downregulates the inflammatory response to endotoxic lipopolysaccharide.
In fact this is what I have been looking for in a prebiotic: an ability to stimulate organisms that possess the ability to neutralize this lipopolysaccharide endotoxin. Many organisms that may act as an antidote of sorts, possess variously structured molecules that mitigate the effects of LPS. Such as through the occupation of the sensors that provoke the immune response to lipopolysaccharide. It appears the closest relatives, those from which gram negative pathogens evolved, have these capabilities. In other words, once you loose them you become infinitely more sensitive to this damn molecule that has few equivalents (to humans) in nature.
What is more toxic to humans than LPS?
The study you referenced identifies some of those clostridal organisms involved in the biosynthesis of butyrate, which of course, is a microbial metabolite, and one that positively regulates the differentiation of FoxP3 cells in the colon. We benefit from the creation of these specialized cells in very specific ways related to minimizing the effects of endotoxins, and the organisms that have proven to be necessary for Treg homeostasis, actually all appear to have vital roles in this process. While Tregs are not only important for regulating the host response to gram negative endotoxins, this appears to be the central feature.
In addition to butyrate availability in the colon, we also know that the carbohydrate outer cell walls of some organisms in our GIT (Bacteroides fragilis) induce the differentiation of CD4 T cells into Foxp3 Tregs. These cells produce IL-10. I suspect that this species polysaccharide A, cell walls which is not endotoxic, serves an immunomodulary role, like butyrate, and downregulates the inflammatory response to endotoxic lipopolysaccharide.
In fact this is what I have been looking for in a prebiotic: an ability to stimulate organisms that possess the ability to neutralize this lipopolysaccharide endotoxin. Many organisms that may act as an antidote of sorts, possess variously structured molecules that mitigate the effects of LPS. Such as through the occupation of the sensors that provoke the immune response to lipopolysaccharide. It appears the closest relatives, those from which gram negative pathogens evolved, have these capabilities. In other words, once you loose them you become infinitely more sensitive to this damn molecule that has few equivalents (to humans) in nature.
What is more toxic to humans than LPS?
