The Resistant Starch Challenge: Is It The Key We've Been Looking For?
- Thread starter Ripley
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@Sidereal
This sounds very promising. I personally believe that everyone stands to benefit from using similar plant compounds: that is, those that are abundant in mucilage. These plants that you mentioned notable for their concentration of exopolysaccharides, and these mucilage rich plants appear to be preferentially utilized by microbial organisms that produce exopolysaccharides themselves; exopolysaccharides that benefit both host and microbes. Although I am more familiar with those commensals that produce these than any pathogens that produce exopolysaccharides, the organisms that I am concentrating on as having what may be an indispensable role in health, seem to be consistently able to preferentially utilize exopolysaccharide enriched plants or algae, and phytoplanktonic synthesized exopolysaccharides.
Actually, many organisms including fungi can produce exopolysaccharides, but for the core group of organisms from which our mitochondria involved are pretty efficient at utilizing these substances.
LAB also produce exopolysaccharides, and while I continue to believe that these organisms are important, I am no longer convinced they are indispensible based upon genomic analysis. LAB abundance in healthy humans may reflect favorable metabolic conditions that are actually incumbent upon a more primitive group of microorganisms. In other words, an abundance of obligative fermenting LAB may reflect oxidative status, which seems to be dependent upon more even more fundamental metabolic processes carried out by functionally-superior organisms.
I presume that plants that are highly abundant in exopolysaccharides afford the plant with an evolutionary advantage because they can provide extra carbohydrates for their microbial inhabitants, which includes being a substrate for growth and offering protection from competing (invasive) organism (a.k.a. biofilm for the good guys). It also appears that much of these bacterial metabolites are of direct benefit to the host.
Early metabolomic studies of humans have shown that there are enormous contributions for microbes. The accumulation of phenolic compounds and the scarcity of indolic compounds stands out.
Phenolic plant compounds like coumarin, catechin, or flavonoids carry out specific roles in plants as anti-infective, root-growth stimulating, etc. Plants that today are valued as spices have enormous ability as biological modifiers. Why is green tea healthful? I'm willing to bet that one reason is that catechins, for example, are extraordinarily stimulating for one of these billion year old commensal species. The health benefits of these compounds are clearly tied to their microbial beneficiaries. This also explains, in part, why some are exquisitely sensitive to these compounds, as they do not have the necessary microbial or host metabolic capacities to metabolize these or other associated compounds.
I think this purposeful. In some ways the functions of these plant compounds in humans is similar to what happens in plants.
Many of the precious herbs and spices that humans have come to prefer are not simply anti-oxidants, and anti-bacterial agents, which of course benefit plants and humans, but they specifically defenses against pathogens. I've been looking at the micro-organisms that protect roots from fungal organisms for example, and I see lots of chitin-degrading organisms.
Plants, like humans, also require protection from gram-negative pathogens, so I have been studying how this takes place. It seems that what is good for plant growth is generally pretty good for humans, and a much more limited number of ancestrally-related organisms starts to show up. This extends not only to exopolysaccharides, but other growth factors, including the aforementioned non-carbohydrate compounds and inorganic minerals.
I think these same microbial-plant relationship parallel microbial-host relationships based upon homologous gene transfer.
It is interesting that some of these plant compounds help promote their own survival and the survival of other symbionts in ways that might not be so obvious. They ostensibly protect us from excessive sun exposure (plants need protection from the sun too) by intervening in the tyrosine/melanin/phenyalanine pathways. This is critical in the maintanance of an appropriate immune response in humans given the role of vitamin D in T-reg creation differentiation/macrophage function. (in fact all the parts to t-regs/innate immunity/mucosal immunity/ is metabolically driven by our microbes).
So if you allow me to speculate, I think you have jump-started IAA biosynthesis, which I believe represents a key metabolic product that is endogenously synthesized from tryptophan with help from microbial symbionts. Its metabolties enhances barrier function and energy biosynthesis. In fact I have never before seen a metabolite with similar biological activity.
Let's hope the inflammatory response is not around the corner.
This sounds very promising. I personally believe that everyone stands to benefit from using similar plant compounds: that is, those that are abundant in mucilage. These plants that you mentioned notable for their concentration of exopolysaccharides, and these mucilage rich plants appear to be preferentially utilized by microbial organisms that produce exopolysaccharides themselves; exopolysaccharides that benefit both host and microbes. Although I am more familiar with those commensals that produce these than any pathogens that produce exopolysaccharides, the organisms that I am concentrating on as having what may be an indispensable role in health, seem to be consistently able to preferentially utilize exopolysaccharide enriched plants or algae, and phytoplanktonic synthesized exopolysaccharides.
Actually, many organisms including fungi can produce exopolysaccharides, but for the core group of organisms from which our mitochondria involved are pretty efficient at utilizing these substances.
LAB also produce exopolysaccharides, and while I continue to believe that these organisms are important, I am no longer convinced they are indispensible based upon genomic analysis. LAB abundance in healthy humans may reflect favorable metabolic conditions that are actually incumbent upon a more primitive group of microorganisms. In other words, an abundance of obligative fermenting LAB may reflect oxidative status, which seems to be dependent upon more even more fundamental metabolic processes carried out by functionally-superior organisms.
I presume that plants that are highly abundant in exopolysaccharides afford the plant with an evolutionary advantage because they can provide extra carbohydrates for their microbial inhabitants, which includes being a substrate for growth and offering protection from competing (invasive) organism (a.k.a. biofilm for the good guys). It also appears that much of these bacterial metabolites are of direct benefit to the host.
Early metabolomic studies of humans have shown that there are enormous contributions for microbes. The accumulation of phenolic compounds and the scarcity of indolic compounds stands out.
Phenolic plant compounds like coumarin, catechin, or flavonoids carry out specific roles in plants as anti-infective, root-growth stimulating, etc. Plants that today are valued as spices have enormous ability as biological modifiers. Why is green tea healthful? I'm willing to bet that one reason is that catechins, for example, are extraordinarily stimulating for one of these billion year old commensal species. The health benefits of these compounds are clearly tied to their microbial beneficiaries. This also explains, in part, why some are exquisitely sensitive to these compounds, as they do not have the necessary microbial or host metabolic capacities to metabolize these or other associated compounds.
I think this purposeful. In some ways the functions of these plant compounds in humans is similar to what happens in plants.
Many of the precious herbs and spices that humans have come to prefer are not simply anti-oxidants, and anti-bacterial agents, which of course benefit plants and humans, but they specifically defenses against pathogens. I've been looking at the micro-organisms that protect roots from fungal organisms for example, and I see lots of chitin-degrading organisms.
Plants, like humans, also require protection from gram-negative pathogens, so I have been studying how this takes place. It seems that what is good for plant growth is generally pretty good for humans, and a much more limited number of ancestrally-related organisms starts to show up. This extends not only to exopolysaccharides, but other growth factors, including the aforementioned non-carbohydrate compounds and inorganic minerals.
I think these same microbial-plant relationship parallel microbial-host relationships based upon homologous gene transfer.
It is interesting that some of these plant compounds help promote their own survival and the survival of other symbionts in ways that might not be so obvious. They ostensibly protect us from excessive sun exposure (plants need protection from the sun too) by intervening in the tyrosine/melanin/phenyalanine pathways. This is critical in the maintanance of an appropriate immune response in humans given the role of vitamin D in T-reg creation differentiation/macrophage function. (in fact all the parts to t-regs/innate immunity/mucosal immunity/ is metabolically driven by our microbes).
So if you allow me to speculate, I think you have jump-started IAA biosynthesis, which I believe represents a key metabolic product that is endogenously synthesized from tryptophan with help from microbial symbionts. Its metabolties enhances barrier function and energy biosynthesis. In fact I have never before seen a metabolite with similar biological activity.
Let's hope the inflammatory response is not around the corner.
Maybe, depends on your microbes.
Honey is comprised of some extraordinarily rare sugars, in small concentrations. Good prebiotics for sure, but I can't say I have noticed any particular benefit. One of my son's craves this, and I have learned to feed his natural food cravings. Surprised to see him eat whole flax seed, unaccompanied.
Forgot to say, though its probably obvious, just fold in blueberries at the end.Yum. Sounds delicious. Thank you!
Great news Sidereal.
I know it's hard, but wondering if you are able to isolate which powder is helping the most. Are you bolusing a mix of all three, or one at a time throughout the day?
Great news Sidereal.
I know it's hard, but wondering if you are able to isolate which powder is helping the most. Are you bolusing a mix of all three, or one at a time throughout the day?
One at a time. I think beet root is the most helpful of the three.
adreno
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I finally got my Miyarisan. It was tagged as "supplement" on the declaration. I took 2 tabs yesterday, and 2 tabs today. Standard dosing is 3x6 tabs daily.
So far it's giving me loose stools and slight stomach upset, which I take as a good sign. No lactate hell.
After looking at my metametrix GI fx, I wonder if I need it, though? It seems to be a major producer of IL-10, which suppresses autoimmune conditions such as allergies (which I have). I actually though my levels would be lower.
So far it's giving me loose stools and slight stomach upset, which I take as a good sign. No lactate hell.
After looking at my metametrix GI fx, I wonder if I need it, though? It seems to be a major producer of IL-10, which suppresses autoimmune conditions such as allergies (which I have). I actually though my levels would be lower.
adreno
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No, it doesn't. Only clostridium difficile is tested separately (non-existent on the test). However, clostridia should be major producers of SCFAs, and they are not that high on my test. Rather confusing.
Gondwanaland
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http://www.nature.com/nature/journal/v500/n7461/full/nature12331.html
Tregs are high in ME/CFS, though.
Tregs are high in ME/CFS, though.
Gondwanaland
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So are Clostridia good or bad? @adreno will you keep taking it or quit?
Some are good, some are bad, some are very bad like C. difficile.
Gondwanaland
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That I know, sorry for being so laconic today, I have a bad night's sleep behind me.
I meant are the good Clostridia in theory good or bad for us? I intend to try it either way when I receive it.
Today my standing BP was 117/79, pulse 78 after 15 g of beet root extract taken in two split doses. To put this in perspective, I've been mostly housebound (and have spent a good portion of that time bedridden) for the last 2.5 years with POTS and other ME symptoms.
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Sorry, I see what you are saying now. Good question. They're almost certainly good for autoimmune disease so people make the automatic assumption but ME/CFS almost looks like the opposite of a true autoimmune condition with high Tregs and TGF-beta in some studies.
Gondwanaland
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So ok, I am not the only one confused by the research
So ok, I am not the only one confused by the research
Nope! @adreno started a thread on this topic recently, if you wanna confuse yourself some more.
http://forums.phoenixrising.me/index.php?threads/me-cfs-and-tregs-confused.36116/