I tried it and it seemed to be dead, so I went for locally compounded with living organisms (refrigerated). I am very happy with my probx. A local pharmacy also compounds probx for topical use. Many years ago when I had this problem my GYN recommended applying natural yogurt from the supermarket (Nestle for instance) with a syringe (no needle obviously) rather than prescribing drugs. It worked.I had been taking Lactobif that is supposed to reduce oxalates. I think I will start that again.