Thanks- that's a great paper!
I'm going to quote an excerpt here for the benefit of others:
(spacing added for readability)
That's a nice find.
Garth Nicolson, after doing a lot of research to understand membranes and their dynamics,
has worked to develop treatment, described in this paper:
"Lipid Replacement Therapy, the use of functional oral supplements containing cell membrane phospholipids
and antioxidants, has been used to replace damaged, usually oxidized, membrane glycerophospholipids
that accumulate during aging and in various clinical conditions in order to restore cellular function.
This approach differs from other dietary and intravenous phospholipid
interventions in the composition of phospholipids and their defense against oxidation
during storage, ingestion
, digestion and uptake as well as the use of protective molecules that noncovalently complex with phospholipid micelles
and prevent their enzymatic and bile disruption. Once the phospholipids have been taken in by transport processes, they are protected by several natural mechanisms involving lipid receptors, transport and carrier molecules and circulating cells and lipoproteins
until their delivery to tissues and cells where they can again be transferred to intracellular membranes
by specific and nonspecific transport systems. Once delivered to membrane sites, they naturally replace and stimulate removal of damaged membrane lipids
. Various chronic clinical conditions are characterized by membrane damage, mainly oxidative but also enzymatic, resulting in loss of cellular function.
Recent clinical trials have shown the benefits of Lipid Replacement Therapy in restoring mitochondrial function and reducing fatigue in aged subjects and patients with a variety of clinical diagnoses that are characterized by loss of mitochondrial function and include fatigue as a major symptom."
and this diagram from the paper explains it :
He was driven to learn about this to help his daughter, who had Gulf War Illness and his wife, who had a mycoplasma infection. He found that several infections cause membranes to be damaged (from oxidative and nitrosative stress - a known feature of ME/CFS - see paper I posted above).
He then formulated this product licensed to Allergy Research, Nutricology, and Researched Nutriceuticals, containing the phospholipid constituents of membranes, in the correct ratios, to repair the damaged membranes:
This strategy, of beating back the virus causing the mito fragmentation, reducing peroxynitrites (oxidative and nitrosative stress) with the Pall protocol (folate, MB12, C and BH4), then replenishing lipids with NT Factor, has he'd to measurable gains of function and in labs for me over the past 3 years.
Which is what Nicolson found and then he also worked with Thomas Seyfried, Dominic D'Agostino and others to publish the mito correction paper, also posted above. He's done other trials finding lipid replenishment reduces fatigue.