Dysregulation of the Kennedy Pathway and Tricarboxylic Acid Cycle in ME/CFS (Che et al., 2021) (Pre-print)

Pyrrhus

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Α good question would be : Why is there dysregulation of phospholipid metabolism in the first place ? Is it a consequence of mitochondrial dysfunction?
That's certainly a great question to ask.

To me, the lack of certain phospholipids could come down to a simple secondary nutrient deficiency, as is often seen in the case of chronic inflammation. As an example, a lack of methyl donors would disrupt the activity of Phosphatidyl-ethanolamine methyl-transferase (PEMT) in the liver, compromising the CDP-ethanolamine pathway to the eventual synthesis of phosphatidyl-choline. In this case, the observed lack of certain phospholipids would also be seen in other conditions with chronic inflammation.
 

mariovitali

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Here is something possibly of interest cc: @Janet Dafoe

I used an Information retrieval system i specifically implememted for ME research. It scans 773 medical concepts directly or indirectly related to ME research. I queried these concepts using the following query :

hyperosmotic stress AND red cell deformability

Recall that these are concepts used by Ron Davis during his research with the nano-needle. Here are the results :


Note : "........" denote concepts that are part of active research and have been removed from this list.

phospholipid_human.csv=1.2504535
glucose_6_phosphate.csv=1.2061515
prostaglandin.csv=1.1950134
glycolysis.csv=1.1939175
.............
acetaldehyde.csv=1.1273894
phosphates.csv=1.1272447
free_fatty_acids.csv=1.1001698
nac.csv=1.0557141
phosphatidylcholine.csv=1.0167357
tocopherol.csv=1.0009141
choline.csv=0.9838646
calmodulin.csv=0.95515966
hypoxia.csv=0.9411563
protein_kinase_a.csv=0.9191257
heparin.csv=0.9173651
............
phosphorylation.csv=0.90558237
g_actin.csv=0.87740237
lactate.csv=0.8605659
f_actin.csv=0.856518
glycine.csv=0.8444515
na_k_atpase.csv=0.8443683
glycoproteins.csv=0.83597994
vasoconstriction.csv=0.81866467
epinephrine.csv=0.8121168
leptin.csv=0.77789605
gaba_human.csv=0.7740025
gsh.csv=0.7735821
xanthine_oxidase.csv=0.76674366
nitric_oxide.csv=0.7653496
...................
il_6.csv=0.7196213
h2o2.csv=0.71518743
mitochondria_human.csv=0.71494347
nitric_oxide_synthase.csv=0.71477365
mitochondrial_dysfunction.csv=0.70873874
bilirubin.csv=0.70670485
tau.csv=0.70494086
vitamin_k.csv=0.6885573
heme.csv=0.67370784
heme_biosynthesis.csv=0.65428793
uric_acid.csv=0.65383637
ckd.csv=0.65187293
gpcr.csv=0.64800596
glycosylation.csv=0.6447042
insulin_resistance.csv=0.6297432
catalase.csv=0.6295128
adrenergic_receptors.csv=0.62404096
porphyrins.csv=0.6108846
nucleotides.csv=0.5973406
tnf_alpha.csv=0.55461264
hydrolysis.csv=0.52908313
lactic_acid.csv=0.490879
inflammatory_cytokines.csv=0.45143282
l_arginine.csv=0.4363921
coa.csv=0.38389474
inflammatory_response.csv=0.32453233
copper.csv=0.31508273
igg.csv=0.31243867


I find it extremely interesting that the most higly ranked concept are phospholipids.
 

Learner1

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They sell Choline supplements & other products, I think Amazon sells her items now Dr. Diana Driscoll
www.potscare.com
It is more than just choline and phosphatidyl choline. One needs ALL the membranes phospholipids. Please see my links above...

Here is something possibly of interest cc: @Janet Dafoe

I used an Information retrieval system i specifically implememted for ME research. It scans 773 medical concepts directly or indirectly related to ME research. I queried these concepts using the following query :

hyperosmotic stress AND red cell deformability

Recall that these are concepts used by Ron Davis during his research with the nano-needle. Here are the results :


Note : "........" denote concepts that are part of active research and have been removed from this list.

phospholipid_human.csv=1.2504535
glucose_6_phosphate.csv=1.2061515
prostaglandin.csv=1.1950134
glycolysis.csv=1.1939175
.............
acetaldehyde.csv=1.1273894
phosphates.csv=1.1272447
free_fatty_acids.csv=1.1001698
nac.csv=1.0557141
phosphatidylcholine.csv=1.0167357
tocopherol.csv=1.0009141
choline.csv=0.9838646
calmodulin.csv=0.95515966
hypoxia.csv=0.9411563
protein_kinase_a.csv=0.9191257
heparin.csv=0.9173651
............
phosphorylation.csv=0.90558237
g_actin.csv=0.87740237
lactate.csv=0.8605659
f_actin.csv=0.856518
glycine.csv=0.8444515
na_k_atpase.csv=0.8443683
glycoproteins.csv=0.83597994
vasoconstriction.csv=0.81866467
epinephrine.csv=0.8121168
leptin.csv=0.77789605
gaba_human.csv=0.7740025
gsh.csv=0.7735821
xanthine_oxidase.csv=0.76674366
nitric_oxide.csv=0.7653496
...................
il_6.csv=0.7196213
h2o2.csv=0.71518743
mitochondria_human.csv=0.71494347
nitric_oxide_synthase.csv=0.71477365
mitochondrial_dysfunction.csv=0.70873874
bilirubin.csv=0.70670485
tau.csv=0.70494086
vitamin_k.csv=0.6885573
heme.csv=0.67370784
heme_biosynthesis.csv=0.65428793
uric_acid.csv=0.65383637
ckd.csv=0.65187293
gpcr.csv=0.64800596
glycosylation.csv=0.6447042
insulin_resistance.csv=0.6297432
catalase.csv=0.6295128
adrenergic_receptors.csv=0.62404096
porphyrins.csv=0.6108846
nucleotides.csv=0.5973406
tnf_alpha.csv=0.55461264
hydrolysis.csv=0.52908313
lactic_acid.csv=0.490879
inflammatory_cytokines.csv=0.45143282
l_arginine.csv=0.4363921
coa.csv=0.38389474
inflammatory_response.csv=0.32453233
copper.csv=0.31508273
igg.csv=0.31243867


I find it extremely interesting that the most higly ranked concept are phospholipids.
Er, exactly what does this list denote?