Dr Igor Markov Says ME/CFS Is Caused by a Bacterial Dysbiosis in the Kidneys, and Says Autovaccine Therapy Cures 93% of ME/CFS Cases

[Cipher]

Thanks. Can you clarify "then to base"?

You can read more here.

 

[bensmith]

@Learner1 doc said you will go back to baseline. After improvemts. Then more improvements, back to baseline. Rinse repeat.

this is what they told hip. And he seems to be experiencing it as well.

 

[Learner1]

Thanks. It does seem that having all these different threads makes it confusing to follow.

@bensmith, it is not clear to me what baseline is. In my case treatment for my stage 3 cancer triggered my ME/CFS, though I have had a lot of symptoms and abnormalities found by ME/CFS researchers and was diagnosed by a top specialist. Does this mean I get my cancer back?

Additionally, I'm pretty sure I'm not in the sane subset as @Hip so am not understanding how we'd be cured by the same cure.

And, I'm still not clear on how this treatment addresses EBV, HHV6, adrenal insufficiency, nutrient deficiencies and mitochondrial dysfunction. I asked Markov and got no answer.

 

[bensmith]

@Learner1 i dont think cancer would come back.

the dr seems to theorize that itd all caused by one thing.

its not clear yet, we dont know. But hopefully we will see folks getting impvroment.

yes its hard to follow lol

And its hipsman not hip, also a bit confusing ha

 

[Hipsman]

@Hipsman Are you cured yet? what's your current thought on the effectiveness of Markov's methodology for testing and treatment? Should we start flying halfway around the world to try it yet?

Cipher quoted my last update, I basically had mild improvement from 19 July to 4 August (plus/minus a day), then this improvement was gone and I returned to feeling exactly how I felt before I started Dr.Markov's treatment.

Before my treatment with the vaccines began Dr Igor Markov said that staphylococcus aureus is not the main bacteria that causes problems for me, we haven't found the main pathogenic bacteria yet, I hope we will find the bastard after a couple more 3-days-in-a-row warm urine bacterial culture tests, if everything goes to plan, then in around 2-3 months we will find that main pathogenic bacteria, and then do the autovaccine treatment against it.

I think that testing to find the main pathogenic bacteria can be very tricky in some cases, during my first consultation, Dr Igor Markov said that in one patient it took 15 urine bacterial cultures to finally find a hiding bacteria, so it was only on 15th time that they were able to culture it. And that patient got allot better only after 4 autovaccine shots for that bacteria. (I think by 15th time he meant that after five of 3-days-in-a-row warm urine bacterial culture tests - 5 X 3 = 15)

Ukraine has very cheap lab tests compared to US, so the ticket and a week in hotel could pay off if you order all immune and pathogen testing that are used by some me/cfs doctors...

BTW, this thread is meant for questions directly to Dr. Igor Markov, maybe a mod can more the posts over to the discussion thread?

 

[Hip]

Before my treatment with the vaccines began Dr Igor Markov said that staphylococcus aureus is not the main bacteria that causes problems for me, we haven't found the main pathogenic bacteria yet, I hope we will find the bastard after a couple more 3-days-in-a-row warm urine bacterial culture tests, if everything goes to plan, then in around 2-3 months we will find that main pathogenic bacteria, and then do the autovaccine treatment against it.

I wonder if there are any ways to provoke the growth of this culprit bacterium in the kidneys, so that it might be more easily detected?

BTW, this thread is meant for questions directly to Dr. Igor Markov, maybe a mod can more the posts over to the discussion thread?

This CBIS summary thread is also a discussion thread, so it is fine to chat here. The Dr Markov Q&A thread you were thinking of is this one.

 

[Learner1]

Cipher quoted my last update, I basically had mild improvement from 19 July to 4 August (plus/minus a day), then this improvement was gone and I returned to feeling exactly how I felt before I started Dr.Markov's treatment.

Before my treatment with the vaccines began Dr Igor Markov said that staphylococcus aureus is not the main bacteria that causes problems for me, we haven't found the main pathogenic bacteria yet, I hope we will find the bastard after a couple more 3-days-in-a-row warm urine bacterial culture tests, if everything goes to plan, then in around 2-3 months we will find that main pathogenic bacteria, and then do the autovaccine treatment against it.

I think that testing to find the main pathogenic bacteria can be very tricky in some cases, during my first consultation, Dr Igor Markov said that in one patient it took 15 urine bacterial cultures to finally find a hiding bacteria, so it was only on 15th time that they were able to culture it. And that patient got allot better only after 4 autovaccine shots for that bacteria. (I think by 15th time he meant that after five of 3-days-in-a-row warm urine bacterial culture tests - 5 X 3 = 15)

Thank you very much for your detailed answer. I hope you're successful in finding it and feel better soon.

But, I wonder, was any of this testing on your immune system? Do these autovaccines work if you're immunodeficient in any way? Like low NK cells or function, low B cells or gammaglobulins?

What about biofilms? Do these bacteria live in biofilms in the kidney tubules?

And what if these infections have stressed your system, creating oxidative and nitrosative stress, adrenal or thyroid hormone insufficiency, depleted nutrients, viral reactivations? How are those addressed with this program?

Ukraine has very cheap lab tests compared to US, so the ticket and a week in hotel could pay off if you order all immune and pathogen testing that are used by some me/cfs doctors...

It sounds like this process is taking multiple months for you. So that sounds a little costly. Though I did check and I could fly there for about US$900 and stay for $500 a week plus eating and ground transport.

However, the US Embassy website says this:

"NEW: or a document confirming the receipt of a full course of vaccination against COVID-19 with vaccines on WHO’s list of approved vaccines (children under 12 are exempt from the testing and vaccination requirements). [Note: A CDC vaccination card is an acceptable proof of vaccination.]
an
– proof of medical insurance covering all expenses related to COVID-19 treatment while on the territory of Ukraine. Ukrainian health insurance coverage can be purchased online – https://visitukraine.today/. You can find further details and exceptions from this requirement on the Ministry’s website"

So, I guess we have to buy health insurance, too. It looks like 8.3% of the population has had COVID vaccines.

 

[Hipsman]

I wonder if there are any ways to provoke the growth of this culprit bacterium in the kidneys, so that it might be more easily detected?

I will try to ask this Dr. Igor Markov next time, but I asked this question in the clinic and one of the med workers that worked for a long time in Markov's clinic said that one patient reported that he was only able have the bacteria cultured successfully when he drank beer before sleep.

I tried this method, but because I have overactive bladder, I had to pee frequently during the night, and peeing frequently means that there won't be much bacteria to culture. I think it's better to have at least 5-6 hours of no bathroom breaks to be able to culture the bacteria successfully. (I tried to culture the bacteria for the first time while having frequent bathroom breaks during the night and nothing cultured)

Also, trying to remember to do the culturing in the mourning just makes this overactive bladder worse, because you get nervous and the bladder becomes even more active...

The only solution I found is to not drink any water 2 hours before sleep. only this way I can sleep through the night without going to the bathroom.

I will try to drink beer 2-3 hours before sleep for the next 3-days bacteria culture tests and see if it works...

But, I wonder, was any of this testing on your immune system? Do these autovaccines work if you're immunodeficient in any way? Like low NK cells or function, low B cells or gammaglobulins?

What about biofilms? Do these bacteria live in biofilms in the kidney tubules?

And what if these infections have stressed your system, creating oxidative and nitrosative stress, adrenal or thyroid hormone insufficiency, depleted nutrients, viral reactivations? How are those addressed with this program?

I was tested for common autoimmune markers before the vaccine course (all negative/normal), specifically this:

• Immunoglobulin E (IgE)
• autoimmune standard panel (14 antigens)
• Complex determination of the immune status by flow cytometry (7 subpopulations of cells), Circulating Immune Complexes (CIC)
• Total immunoglobulins IgA, IgM, IgG and complement C3, C4

I don't know the answer to your questions, but I would imagine being immunodeficient means you will need more vaccination cycles, this is just a guess thou.

 

[Cipher]

I wonder if there are any ways to provoke the growth of this culprit bacterium in the kidneys, so that it might be more easily detected?

I will try to drink beer 2-3 hours before sleep for the next 3-days bacteria culture tests and see if it works...

SGLT2 inhibitors are used for treating type 2 diabetes and work by increasing the kidneys excretion of glucose in the urine. A known adverse effect from SGLT2 inhibitors are urinary tract infections. Perhaps taking a SGLT2 inhibitor and increasing ones sugar intake a couple of days before the urine culture might increase the chance of finding the pathogen?

 

[Learner1]

I will try to ask this Dr. Igor Markov next time, but I asked this question in the clinic and one of the med workers that worked for a long time in Markov's clinic said that one patient reported that he was only able have the bacteria cultured successfully when he drank beer before sleep.

I tried this method, but because I have overactive bladder, I had to pee frequently during the night, and peeing frequently means that there won't be much bacteria to culture. I think it's better to have at least 5-6 hours of no bathroom breaks to be able to culture the bacteria successfully. (I tried to culture the bacteria for the first time while having frequent bathroom breaks during the night and nothing cultured)

Also, trying to remember to do the culturing in the mourning just makes this overactive bladder worse, because you get nervous and the bladder becomes even more active...

The only solution I found is to not drink any water 2 hours before sleep. only this way I can sleep through the night without going to the bathroom.

I will try to drink beer 2-3 hours before sleep for the next 3-days bacteria culture tests and see if it works...



I was tested for common autoimmune markers before the vaccine course (all negative/normal), specifically this:

• Immunoglobulin E (IgE)
• autoimmune standard panel (14 antigens)
• Complex determination of the immune status by flow cytometry (7 subpopulations of cells), Circulating Immune Complexes (CIC)
• Total immunoglobulins IgA, IgM, IgG and complement C3, C4

I don't know the answer to your questions, but I would imagine being immunodeficient means you will need more vaccination cycles, this is just a guess thou.

So, biofilms are in the majority of bacterial infections.

https://www.hindawi.com/journals/ab/2014/543974/

I'm not understanding how the autovaccines can get through the slimy biofilms to kill off the bacteria?

 

[Learner1]

And what about Epstein Barr, HHV6, Cocksackie viruses,, etc?

 

[Hip]

So, biofilms are in the majority of bacterial infections.

https://www.hindawi.com/journals/ab/2014/543974/

I'm not understanding how the autovaccines can get through the slimy biofilms to kill off the bacteria?

Autovaccines boost the immune response against the specific species of bacteria the vaccine targets, but I believe bacteria are largely invulnerable to the immune response when they are hiding inside biofilms. They are also protected from antibiotics whist they live in biofilms.

However, if you look at the biofilm bacteria lifecycle (see image below), you see that at one point in this cycle, bits of biofilm break off due to mechanical force, which then release the bacteria they contain, so they become free-floating bacteria once more (free-floating bacteria are called planktonic bacteria).

Biofilm Bacteria Lifecycle

These planktonic bacteria will then go off and create a new biofilm community (see the long dotted arrow in the above image). And so the cycle repeats.

I would imagine that while these bacteria are in the planktonic state, that is the time the immune system will be able to destroy them. So if you have vaccine-enhanced antibacterial immune responses against these bacteria, it will thwart the biofilm lifecycle of the bacteria, and so slowly over time, the biofilm communities will diminish.

So that's my guess as to how autovaccines work against biofilm bacteria: they cause the immune system to more fiercely attack the bacteria when they are in their vulnerable planktonic state.

And what about Epstein Barr, HHV6, Cocksackie viruses,, etc?

That is a very good question. Dr Igor Markov does not think that viral infections are playing a major role in ME/CFS, but we know that viral infection triggers most cases of ME/CFS, so the question remains on how we might reconcile and integrate the viral theories of ME/CFS with Dr Markov's kidney bacterial dysbiosis (nephrodysbacteriosis) theory of ME/CFS.

If you have a look at this earlier post, I have tried to reconcile Dr Markov's theory with various known aspects of ME/CFS (like mitochondrial issues, autoimmunity), including the viral theories of ME/CFS. See in particular "The Viral Connection" section of that post.

It occurred to me that viruses might be chronically infecting the kidneys, altering local immunity in this organ, and/or be causing some other issues in the organ, such as tissue damage that allows bacterial toxins to more easily leak from the kidneys. In this way, viruses may be setting the stage for a bacterial dysbiosis in the kidneys.

Well it turns out that coxsackievirus B can chronically infect the kidneys, and indeed this virus has been linked to kidney diseases. So that certainly suggests that potentially, a chronic viral infection might be able to set the stage for bacterial dysbiosis in the kidneys.

Similarly, Epstein-Barr virus is also able to chronically infect the kidneys. See also here.

 

[Violeta]

This is a study about an extreme condition but see what you think about the cause and the remedy that is used.
HERPES VIRUSES ORAL SHEDDING IN CHRONIC RENAL PATIENTS
https://www.kireports.org/article/S2468-0249(16)30105-X/pdf

 

[Hip]

This is a study about an extreme condition but see what you think about the cause and the remedy that is used.
HERPES VIRUSES ORAL SHEDDING IN CHRONIC RENAL PATIENTS
https://www.kireports.org/article/S2468-0249(16)30105-X/pdf

I think that study is more about the viral reactivations that can occur throughout the body in the case of chronic kidney disease, a disease which causes a number of issues including immune depression (hence the reactivations).

So in chronic kidney disease the viral infections themselves are not necessarily located in the kidneys.

 

[Hipsman]

SGLT2 inhibitors are used for treating type 2 diabetes and work by increasing the kidneys excretion of glucose in the urine. A known adverse effect from SGLT2 inhibitors are urinary tract infections. Perhaps taking a SGLT2 inhibitor and increasing ones sugar intake a couple of days before the urine culture might increase the chance of finding the pathogen?

Worth a shot, I looked at the SGLT2 inhibitors listed on that wiki page, I can get Dapagliflozin or Empagliflozin locally...

 

[hb8847]

Before my treatment with the vaccines began Dr Igor Markov said that staphylococcus aureus is not the main bacteria that causes problems for me, we haven't found the main pathogenic bacteria yet, I hope we will find the bastard after a couple more 3-days-in-a-row warm urine bacterial culture tests, if everything goes to plan, then in around 2-3 months we will find that main pathogenic bacteria, and then do the autovaccine treatment against it.

Correct me if I'm wrong but I thought Markov had claimed that most patients' infections are caused by a few certain types of bacteria, and in light of this he was designing a "one size fits all" autovaccine which would eliminate the need for extensive testing with urine cultures?

Would this not go against Hipsman's process of needing months of testing in order to identify their specific bacterial infection? Why bother, why would Markov not just trial patients with a bunch of "common" autovaccines whilst simultaneously getting them tested?

(Not asking you specifically @Hipsman , just wondering about Markov's process.)

 

[Hip]

Correct me if I'm wrong but I thought Markov had claimed that most patients' infections are caused by a few certain types of bacteria, and in light of this he was designing a "one size fits all" autovaccine which would eliminate the need for extensive testing with urine cultures?

That is correct, but a one-size-fits-all vaccine (it would be a vaccine, not an autovaccine), which targets the most common species of bacteria found in nephrodysbacteriosis/CBIS, would have to be developed in conjunction with a pharmaceutical company, and would have to undergo proper phase I to III clinical trials, which is a lengthy and expensive process taking many years.

You cannot legally create a new vaccine and use it on patients without it undergoing full clinical trials. That applies to all pharmaceuticals: they must be put through clinical trials before being brought to market.

By contrast, as I understand it, medical regulations allow you to create autovaccines using a bacterial sample from a patient, and use those vaccines on the same patient that the bacteria came from (but not on other patients). Hence the name autovaccine. Medical use of autovaccines dates back to the 1900s.

This is explained in a bit more detail in the first post of this thread, in the section "Future Treatment Developments From Dr Markov".

 

[Hipsman]

Correct me if I'm wrong but I thought Markov had claimed that most patients' infections are caused by a few certain types of bacteria, and in light of this he was designing a "one size fits all" autovaccine which would eliminate the need for extensive testing with urine cultures?

I believe this is because they have 7 (if I remember correctly) 7 versions of already manufactured vaccines with different bacteria in each version, and they chose the right vaccine based on bacteria culture test results.

Also as you said "most patients' infections are caused by a few certain types of bacteria" - so it could be that the rest of the patients have uncommon strains of bacteria that still will have to be cultured and made into actual autovaccines...

I guess they are still designing a "one size fits all" autovaccine and it's not ready yet...

Would this not go against Hipsman's process of needing months of testing in order to identify their specific bacterial infection? Why bother, why would Markov not just trial patients with a bunch of "common" autovaccines whilst simultaneously getting them tested?

I think I wouldn't want to trial all 7 vaccine versions they have as vaccines increase autoimmunity, the stratedgy of trialing vaccines based on test results makes the process much safer then trialing all of them.


Also, to complete one cycle of the vaccine I was prescribed requires around 2.5 months, so I think if you were to trial all 7 versions it would take minimum of 14-20 months, and you would also need to take breaks between trialing different versions to let the immune system normalize and lower the chances of autoimmune reactions...

That is correct, but a one-size-fits-all vaccine (it would be a vaccine, not an autovaccine), which targets the most common species of bacteria found in nephrodysbacteriosis/CBIS, would have to be developed in conjunction with a pharmaceutical company, and would have to undergo proper phase I to III clinical trials, which is a lengthy and expensive process taking many years.

You cannot legally create a new vaccine and use it on patients without it undergoing full clinical trials. That applies to all pharmaceuticals: they must be put through clinical trials before being brought to market.


By contrast, medical regulations allow you to create autovaccines using a bacterial sample from a patient, and use those vaccines on the same patient that the bacteria came from (but not on other patients). Hence the name autovaccine. Medical use of autovaccines dates back to the 1900s.

I don't think this applies to Ukraine, Dr Igor Markov prescribed me already made vaccine for Staphylococcus that they manufacture (Staphylo-Primavac vaccine)

It consists of:

Inactivated cells of no less then 21 strains of Staphylococcus: Staphylococcus Aureus - 15 strains, Staphylococcus haemolyticus - 3 strains, Staphylococcus epidermidis - 3 strains. 1ml of vaccine contains no less then 1.5 billion inactivated bacterial cells"

 

[Hip]

I don't think this applies to Ukraine, Dr Igor Markov prescribed me already made vaccine for Staphylococcus that they manufacture (Staphylo-Primavac vaccine)

I did not realize that Dr Igor Markov is actually prescribing the various bacterial vaccines he has invented and developed. I thought those were still awaiting clinical trials.

In this post by Oleg Markov, it is explained that Igor Markov has developed various vaccines against the typical bacteria found in urinary tract infections, including the Eco-Primavac vaccine (for pathogenic Escherichia coli and Enterococcus species), and the Staphylo-Primavac vaccine (for various Staphylococcus species).

But Dr Markov also explains in that post that whilst it is not necessary to conduct double-blind placebo-controlled clinical trials for autovaccines, these clinical trials would be required for his various invented vaccines, if they are to be used in different countries around the world. So clinical trials would be required for global use of Dr Markov's vaccines.

But maybe as you say, the rules are different in the Ukraine: maybe the regulatory requirements are not as stringent in Ukraine, and so he is able to use his invented vaccines for patients in the Ukraine?

 

[bensmith]

@Hip that is interesting


Thanks for the update @Hipsman , looking forward to how things go. Thank God you are there, otherwise i dont think we could ever know.

i hope you find the right one soon.

did the dr find a marker of some kind, so he knows you have bacteria? He just doesn’t know which one?

sorry if you have answered.

cheers.