Completely eliminated my severe anxiety symptoms with three supplements!

kyzcreig · Apr 20, 2015

I found manganese was helpful for paranoia. Especially if you're CBS. Not exactly anxiety, but similar.

starlily88 · Apr 20, 2015

Hip said:
The turmeric dose I suggested is 1000 mg, which is about half a level teaspoon.

Thanks Hip. I did not get how to best ingest the tumeric - it's not like a tsp of honey for me (I have Sjorgen's so dry).
Found Jiva Organic Tumeric ground 16 oz bottle. I see people mix it in coffee, mix tumeric with yogurt and
a clove of mashed garlic. Some put Tumeric into cup almond milk, add coconut oil little ginger powder.
I didn't get why it is not OK to do Tumeric powder capsule which contain curcumin..Thanks for telling me.

Yes - I don't just have GAD (generalized anxiety disorder). I jump at any sound like someone said Boo!
Had this in beginning of my disease. Now it has returned. The irritablity, impatience, withdrawing from outside world new in last couple years. I almost seem to have a shadow asperger's now.

I wanted to do low dose amisulpride 12.5 mg. Still aftraid of effect on me after one year. I get reactions that drs say they have never seen in their career, like loosing all white blood cells on drug docs used off brand.
I have ADHD and extreme noise sensitivity. I have anti-anhedonia, with anxiery psychosis symptoms. I have reversed cycle sleep - sleep day, up night.

You seem to be only one speaking out on the normal side effects of CFS on mood, social interaction, stimuli.
I thank you for providing me with a large template to try out - even down to Vitamin A 25, 000 IU - I assume not to take Beta Carotene but Vitamin A?

Hip · Apr 20, 2015

starlily88 said:
Thanks Hip. I did not get how to best ingest the tumeric

What I do myself is place around 1000 mg of turmeric in my mouth (using a teaspoon), and then I drink a gulp of water, swill the water around my mouth (with my mouth closed) to mix all the turmeric into the water, and swallow. I then drink some more water to help swallow any remaining bits of turmeric in the mouth. It does make the tongue go bright orange for a while, but this can be brushed off with a toothbrush if necessary.

Very low dose amisulpride 12.5 mg still works wonders for me. Although people are wary of anti-psychotics because of the side effects, in fact I found very low dose amisulpride a very "clean" feeling drug, both on mind and body. It does not feel like a drug at all, in fact, more like a supplement. As soon as I stop taking amisulpride, I become impossibly irritable.

I have not tested beta carotene, so I cannot comment on its anti-inflammatory / anti-anxiety effects, but it's worth trying, and comparing to vitamin A.

starlily88 · Apr 22, 2015

Hip, thanks for info. I investigated the NAG.. Disappointed it was made with Shrimp, Crab and lobster shells.
I have severe shrimp allergy - stop breathing. Figure I'd take chance but apparently one can't take chance.

I don't like doing a tsp of tumeric in mouth. My entire place is now orange, and it is difficult to swallow.
I want to try PurelyHolistic.org kind - which is non-GMO, made in USA, uses no fillers at all.
This is The Tumeric Curcumin you say not to take, but notice you do list Curcumin on your 29 list.

At least I can try the Flaxseed Oil and Acetyl-L-carnitine. .
I do want to buy the Amisulpride = from InHouse but the lowest they have is 100 mg.
I am not comfortable buying 50 mg from India - where do you buy it from now??
Thanks a lot

Hip · Apr 22, 2015

I think the last time I bought amisulpride it was from United Pharmacies. Goldpharma.com also sell many brands of amisulpride.

starlily88 · Apr 22, 2015

Hip This is huge thread you have - I went back to Feb 2013. Read how much effect one gets from Tumeric and how the other ones with curcumin don't have the good things in Tumeric powder. Just ordered plain Tumeric from iherb.

Two questions. You mention to buy NAG synthetic without made from shellfish. Went to 4 sites, can't find it.
I am going to order Jarrow on iherb made from crawfish and crabs .
If I can find synthetic one from you - it would be better!

If anyone on here got NAG synthetic without shrimp please let me know.

Also, I found how to order amisulpride from your thread, I thought - where you have number 1 - 6 which is URL for the pharmacies that sell it. I only did 1st (Inhouse) then 2nd India.

Can't find the URL in your Treatment protocol - can you direct me to 6 pharmacies please?

Thanks

Hip · Apr 22, 2015

I don't know where you can buy shellfish-free NAG. I have not seen it.

starlily88 said:
Also, I found how to order amisulpride from your thread, I thought - where you have number 1 - 6 which is URL for the pharmacies that sell it. I only did 1st (Inhouse) then 2nd India.

Can't find the URL in your Treatment protocol - can you direct me to 6 pharmacies please?

I don't understand your question here. Please explain.

starlily88 · Apr 22, 2015

Hip, I want to order amisulpride. You provided 6 pharmacies online in which I can order from.
Can't find the link you provided to get to 6 pharmacies I can buy it from online

starlily88 · Apr 22, 2015

I just found the link - you had amisulpride, and said find it "here" - that got me to 6 pharmacies
Thanks Hip

bretjake · May 14, 2015

Dear Hip,

I have ordered NAG and turmeric. I already have Krill oil which sits in when for the flaxseed. I have a general anxiety disorder which I was taking Cipralex (Lexapro), an SSRI, for and it worked fine until, 2 years in, it began giving me bowel urgency and diarrhea. It also stopped working as effectively as it once had. I weaned myself off it and stopped it; 6 weeks later I was a mess and suicidal (a first for me) but the gut problems began to cease, which confirmed the meds as being the cause. I got back on a quarter dose to stabilise a bit and have now been at my father's house in the forest on a mountain for 2 months. We tried two other meds in this time with the aid of my psychiatrist with no good results. We aim to keep trying but in the meantime, I will be trying the NAG and turmeric

I doubt my disorder is due to brain inflammation as I had a blood test months ago (CRP I think) which is said to indicate for inflammation anywhere in the body and it came up negative. Having said that, I don't know how reliable those tests are. Can you confirm?

What I can't find online is: doe brain inflammation cause mood disorders or can mood disorders also cause inflammation? What I mean to ask is, can it be a two-way street?

Finally, in your opinion, do you think it would be possible (and I understand that you're not a doctor so this is just a request for friendly advice) to use supplements from the upper segregation on your list in order to dispel a mood disorder, regardless of if it is caused by inflammation or not?

The reason I ask all this is because I need to become functional again so that I can go back into town, begin Cognitive Behavioral Therapy sessions and restart my life.

Apologies for the multiple inquiries and thank you for your time,

Baret

Hip · May 14, 2015

bretjake said:
I doubt my disorder is due to brain inflammation as I had a blood test months ago (CRP I think) which is said to indicate for inflammation anywhere in the body and it came up negative. Having said that, I don't know how reliable those tests are. Can you confirm?

I don't know that much about it, but I understand C-reactive protein (CRP) is a measure of the overall inflammation in your body, and I don't think it will necessarily pick up local inflammation in the brain.

bretjake said:
What I can't find online is: doe brain inflammation cause mood disorders or can mood disorders also cause inflammation? What I mean to ask is, can it be a two-way street?

Increasingly mood disorders are being seen as an underlying physical dysfunction in the brain, rather than viewed as due to psychological factors (such as bad childhood experiences or learned conditions). Physical dysfunctions would include brain inflammation.

However, many psychiatrists still work with the idea that mood disorders are due to psychological factors.

So in your question, how are you viewing mood disorders? Are you viewing mood disorders as something psychological, or something that results from a physical dysfunction in the brain?

bretjake said:
Finally, in your opinion, do you think it would be possible (and I understand that you're not a doctor so this is just a request for friendly advice) to use supplements from the upper segregation on your list in order to dispel a mood disorder, regardless of if it is caused by inflammation or not?

The anti-anxiety supplements in my list were discovered by testing: I tested hundreds of supplements, and found that some supplements had good anti-anxiety effects. Afterwards I started thinking about how and why these supplements work. I noticed a few supplements (but not all) were anti-inflammatory, and it was from this observation that I started thinking that neuroinflammation might be the cause of my generalized anxiety disorder.

From reading online, I learnt there is a wave of new research indicating neuroinflammation may be behind many types of mood disorders, such as depression, schizophrenia, etc. So that's how I started to think that generalized anxiety disorder might be due to neuroinflammation. But this is only an idea and a theory; it may not be correct.

So I suggest you only use this neuroinflammation theory for guidance, but not as an absolute truth.

However, because I tested these supplements empirically, I know they all have good anti-anxiety effects. And they may help other mood disorders as well.

bretjake · May 14, 2015

Hip said:
I don't know that much about it, but I understand C-reactive protein (CRP) is a measure of the overall inflammation in your body, and I don't think it will necessarily pick up local inflammation in the brain.

Increasingly mood disorders are being seen as an underlying physical dysfunction in the brain, rather than viewed as due to psychological factors (such as bad childhood experiences or learned conditions). Physical dysfunctions would include brain inflammation.

However, many psychiatrists still work with the idea that mood disorders are due to psychological factors.

So in your question, how are you viewing mood disorders? Are you viewing mood disorders as something psychological, or something that results from a physical dysfunction in the brain?

The anti-anxiety supplements in my list were discovered by testing: I tested hundreds of supplements, and found that some supplements had good anti-anxiety effects. Afterwards I started thinking about how and why these supplements work. I noticed a few supplements (but not all) were anti-inflammatory, and it was from this observation that I started thinking that neuroinflammation might be the cause of my generalized anxiety disorder.

From reading online, I learnt there is a wave of new research indicating neuroinflammation may be behind many types of mood disorders, such as depression, schizophrenia, etc. So that's how I started to think that generalized anxiety disorder might be due to neuroinflammation. But this is only an idea and a theory; it may not be correct.

So you should only use this neuroinflammation theory for guidance, but not as an absolute truth.

However, because I tested these supplements empirically, I know they all have good anti-anxiety effects. And they may help other mood disorders as well.

Thank you very much for the info. To answer your question, I simply don't know if it is psychological or physiological. By your understanding, do you know of any way to test for neuroinflammation?

Thanks again,

Baret

Hip · May 14, 2015

bretjake said:
To answer your question, I simply don't know if it is psychological or physiological.

I tend to think mood disorders are likely mostly caused by physiological factors, not psychological factors, with perhaps the exception of PTSD, which occurs after extreme stress (but even in PTSD, there is evidence to indicate pre-existing physiological factors may be behind those who develop PTSD from extreme stress; for example, people with ADHD are more prone to PTSD).

So my view is that it will likely be a one-way street: neuroinflammation first, which then causes mood disorders.

bretjake said:
By your understanding, do you know of any way to test for neuroinflammation?

I don't really know much about this, but I think you may be entering scientific research territory here. The interest in neuroinflammation causing mood disorders is quite recent, so there may not be any commercially available medical tests outside of the research lab.

I believe in studies, positron emission tomography (PET) brain scans are used to detect neuroinflammation. This was recently used in a groundbreaking study to detect neuroinflammation in ME/CFS patients. Such PET scans also were used to detect neuroinflammation in depression. There may be some other ways to measure neuroinflammation as well, but I have not looked into this thoroughly.

I have not heard of anyone with ME/CFS, depression, etc being tested by their doctor for brain inflammation. Maybe in the future they will.

bretjake · May 15, 2015

Hip said:
I tend to think mood disorders are likely mostly caused by physiological factors, not psychological factors, with perhaps the exception of PTSD, which occurs after extreme stress (but even in PTSD, there is evidence to indicate pre-existing physiological factors may be behind those who develop PTSD from extreme stress; for example, people with ADHD are more prone to PTSD).

So my view is that it will likely be a one-way street: neuroinflammation first, which then causes mood disorders.

I don't really know much about this, but I think you may be entering scientific research territory here. The interest in neuroinflammation causing mood disorders is quite recent, so there may not be any commercially available medical tests outside of the research lab.

I believe in studies, positron emission tomography (PET) brain scans are used to detect neuroinflammation. This was recently used in a groundbreaking study to detect neuroinflammation in ME/CFS patients. Such PET scans also were used to detect neuroinflammation in depression. There may be some other ways to measure neuroinflammation as well, but I have not looked into this thoroughly.

I have not heard of anyone with ME/CFS, depression, etc being tested by their doctor for brain inflammation. Maybe in the future they will.

Thank you very much for the links and the info. Incidentally, have you ever tried Serrapeptase? Its an enzyme from a silkworm in Japan that appears to be a powerful anti-inflammatory. However, I don't know the dosage so I guess I'll experiment until the NAG arrives. I'll tell you one thing, if the NAG works, I'll send you a gift bag of the highest order.

Thanks again

Hip · May 15, 2015

bretjake said:
Incidentally, have you ever tried Serrapeptase? Its an enzyme from a silkworm in Japan that appears to be a powerful anti-inflammatory.

I did try serrapeptase, quite a few years ago, as well as the enzyme supplements bromelain and papain, but did not notice any improvements in anxiety. Not all anti-inflammatories target brain inflammation; they may just act on inflammation in the body.

However, there are circumstances where inflammation in the body can trigger inflammation in the brain, and in these cases, you may be able to successfully reduce brain inflammation (and thus anxiety) by reducing inflammation in your body (systemic inflammation as it is called). For example, if you have some gut problems, like an imbalance of good and bad bacteria in your intestines, this can cause some inflammation in your intestines. This can then kick off neuroinflammation via the vagus nerve.

The vagus nerve, which runs from gut to brain, is designed to detect inflammation in the organs of the body, including the intestines. The vagus does this by sensing the presence of the inflammation cytokine IL-1beta. When the vagus senses inflammation in the body, it will send a nerve signal to the brain, which then triggers an increase in inflammation in the brain. So because of this vagus nerve gut-to-brain communication, any inflammation in your gut can get translated into increased inflammation in the brain as well.

So by improving gut and digestive health, you may be able to reduce anxiety levels. I have IBS, and found that taking prebiotics and probiotics (friendly bacteria) had a powerful anxiety-reducing effect. In fact this was one of the earliest successes I had in terms of finding solutions for my severe generalized anxiety disorder. I started a thread on the anxiolytic effect of prebiotics/probiotics here.

Likewise, the trigeminal nerve, which runs from your nasal and sinus cavities to the brain, is another nerve which senses inflammation in the body. When the trigeminal nerve senses inflammation in the sinuses, it will send a signal to the brain to instigate increased brain inflammation. So nasal or sinus inflammation may trigger brain inflammation, which in turn may cause anxiety symptoms.

I suffer from nasal and sinus congestion and inflammation (due to a chronic viral infection). I noticed that when my sinuses were more inflamed, my anxiety was much worse. So then I started to search for supplements that would decrease my nasal and sinus inflammation (sinusitis). The supplements that I found effectively cleared my sinusitis are listed in this post. These all helped significantly reduce my anxiety levels.

So certainly there are situations where chronic infection or inflammation in the body (systemic inflammation) can trigger neuroinflammation via the vagus or trigeminal nerves, and in these cases, reducing the infection or inflammation can greatly reduce anxiety levels. If you are interested in reading about the vagus nerve and its job of triggering brain inflammation, this article may be of interest.

MeSci · May 15, 2015

Hip said:
I suffer from nasal and sinus congestion and inflammation (due to a chronic viral infection). I noticed that when my sinuses were more inflamed, my anxiety was much worse. So then I started to search for supplements that would decrease my nasal and sinus inflammation (sinusitis). The supplements that I found effectively cleared my sinusitis are listed in this post. These all helped significantly reduce my anxiety levels.

@Hip, if your sinusitis was due to an infection, how do you account for it clearing as a result of supplements?

I too had lifelong anxiety - since childhood, and fixed it - and the sinusitis that had developed in the later years of ME - and several other symptoms - with a leaky-gut diet and supplements, as I probably outlined earlier in this thread.

The details of my own diet and supplements can be found in my profile.

Hip · May 15, 2015

@MeSci
By saying the supplements "effectively cleared my sinusitis," I just meant that they would clear my nasal and sinus cavities of congestion and inflammation while I was taking them. Not permanently cleared.

The inflammatory feeling I get in my nasal cavity and sinuses (like in the frontal sinuses in the forehead, and in the maxillary sinuses either side of the nose) gets significantly reduced after taking these supplements. Within around 6 - 8 hours of taking them, my sinuses and nasal cavity will go from being clogged and inflamed to feeling as clean as a whistle.

At one stage, when my anxiety disorder was horrendously severe, I would even use an electric facial steam bath to breathe in steam via my nose, in order to clear out and de-inflame my nasal cavity and sinuses. This steam bath technique would work quite well, and was very useful when anxiety levels reached torturously high levels on bad days; the facial steam bath would reduce the anxiety quite a bit within 20 minutes.

So for me there definitely seemed to be a link between sinus / nasal cavity inflammation and anxiety.

Note that my sinusitis supplements may not be helpful for sinusitis caused by bacterial infection (often associated with a bad smells in the nose), but seem to work well for the viral sinusitis inflammation I have.

ahmo · May 15, 2015

bretjake said:
have you ever tried Serrapeptase?

I used serrapeptase with other enzymes for about 6 weeks earlier this year. zi did this in conjunction w/ Candida and SIBO protocol. My sense is that the protyolytic enzymes (this and this) significantly lightened the burden on my organs. Or, rather, made my organs able to function more efficiently. I was able to decrease several of my supps afterwards.

Re your condition: if you're still eating gluten and dairy, you should stop. That was the first
step in calming my nervous system.

If you feel it's an inflammatory condition, especially if you have any other symptoms of inflammation, low dose naltrexone is extremely effective for me and many others. There's a long thread here, and several yahoo forums, info sites.

http://forums.phoenixrising.me/index.php?threads/low-dose-naltrexone.292/
http://www.lowdosenaltrexone.org/index.htm
http://www.lowdosenaltrexone.org/index.htm

https://sites.google.com/site/dudleyslowdosenaltrexonesites/

bretjake · May 16, 2015

Hip said:
I did try serrapeptase, quite a few years ago, as well as the enzyme supplements bromelain and papain, but did not notice any improvements in anxiety. Not all anti-inflammatories target brain inflammation; they may just act on inflammation in the body.

However, there are circumstances where inflammation in the body can trigger inflammation in the brain, and in these cases, you may be able to successfully reduce brain inflammation (and thus anxiety) by reducing inflammation in your body (systemic inflammation as it is called). For example, if you have some gut problems, like an imbalance of good and bad bacteria in your intestines, this can cause some inflammation in your intestines. This can then kick off neuroinflammation via the vagus nerve.

The vagus nerve, which runs from gut to brain, is designed to detect inflammation in the organs of the body, including the intestines. The vagus does this by sensing the presence of the inflammation cytokine IL-1beta. When the vagus senses inflammation in the body, it will send a nerve signal to the brain, which then triggers an increase in inflammation in the brain. So because of this vagus nerve gut-to-brain communication, any inflammation in your gut can get translated into increased inflammation in the brain as well.

So by improving gut and digestive health, you may be able to reduce anxiety levels. I have IBS, and found that taking prebiotics and probiotics (friendly bacteria) had a powerful anxiety-reducing effect. In fact this was one of the earliest successes I had in terms of finding solutions for my severe generalized anxiety disorder. I started a thread on the anxiolytic effect of prebiotics/probiotics here.

Likewise, the trigeminal nerve, which runs from your nasal and sinus cavities to the brain, is another nerve which senses inflammation in the body. When the trigeminal nerve senses inflammation in the sinuses, it will send a signal to the brain to instigate increased brain inflammation. So nasal or sinus inflammation may trigger brain inflammation, which in turn may cause anxiety symptoms.

I suffer from nasal and sinus congestion and inflammation (due to a chronic viral infection). I noticed that when my sinuses were more inflamed, my anxiety was much worse. So then I started to search for supplements that would decrease my nasal and sinus inflammation (sinusitis). The supplements that I found effectively cleared my sinusitis are listed in this post. These all helped significantly reduce my anxiety levels.

So certainly there are situations where chronic infection or inflammation in the body (systemic inflammation) can trigger neuroinflammation via the vagus or trigeminal nerves, and in these cases, reducing the infection or inflammation can greatly reduce anxiety levels. If you are interested in reading about the vagus nerve and its job of triggering brain inflammation, this article may be of interest.

Dear Hip,

Thank you for the info. I've looked into it. I have one question: I used to have candida which I thought I had for a lot longer than I actually did and was convinced for the longest time that it was the sole reason for my mood disorder. However, after extensive testing (and I realise that testing for candida can be tricky and misleading), there were no results that warranted a positive diagnosis for candida. One day I thought 'I have no flare-ups, no heavy-duty sinus problems or anal itching like I used to so just maybe, I don't have it anymore.' Having said this, I found that NAG can be a major food source for pathological candida and is used by it to for its outer wall. Could this be a problem when using NAG?

Hip · May 16, 2015

bretjake said:
Having said this, I found that NAG can be a major food source for pathological candida and is used by it to for its outer wall. Could this be a problem when using NAG?

It's feasible NAG might worsen a suspected Candida overgrowth. NAG reduces the Th17 immune response, which helps fight Candida. Th17 is also involved in autoimmunity, so that may be why NAG is good for autoimmune conditions like MS. If you search this thread only (see top right of page) for the word "Candida", you'll see this issue has been discussed.

Completely eliminated my severe anxiety symptoms with three supplements!

kyzcreig

Senior Member

starlily88

Senior Member

Hip

Senior Member

starlily88

Senior Member

Hip

Senior Member

starlily88

Senior Member

Hip

Senior Member

starlily88

Senior Member

starlily88

Senior Member

bretjake

Hip

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bretjake

Hip

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bretjake

Hip

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MeSci

ME/CFS since 1995; activity level 6?

Hip

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ahmo

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bretjake

Hip

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