Low Dose Naltrexone for FM and CFS (?) I knew one person who did very well on low dose naltrexone (LDN). It's another of those odd central nervous system drugs that is being tried out in all sorts of disorders. Originally used to help detox patients going off of opioids and to combat alcohol dependence very low doses of it are being examined in fibromyalgia, AIDS, Parkinson's, MS and other auto-immune diseases, autism, etc. I particularly like it's ability to induce erections. The ME/CFS patient I knew who tried it occasionally couldn't get to sleep because of his erections - an automatic winner in my book. In this recent study on FM patients LDN was described as being an effective, tolerable and inexpensive treatment for them. It's effects occur because They found that If you have a high sedimentation rate you might be in luck. Pain Med. 2009 Apr 22. [Epub ahead of print]Links Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study. Younger J, Mackey S.