@dannybex
There is a very fast way to tell now. If HyCbl or CyCbl causes acne it is causing methyltrap. Then, MeCbl will reverse it in a few days,. The glutathione causing "catastrophic B12 deficiency" is characteristic of certain problems that may be misidentified. So much in B12 research is seriously messed up.
And the language used hides the problem. The understanding of the absorption system has been screwed up for decades.
So for years the research has been pushing the TC1, TC2, TC3, HTC1, HTC2, HTC3 and ID, and expensive use of ATP and enzymes to convert HyCbl and CyCbl to the required COB[II].
Recent research is changing all that. Say goodby to TC1-3 and HTC1-3. Instead there is Haptocorrin in place of TC1 and TC3 and HTC2 and HTC3. And then there is NOW TransCobalamin Receptor (TCR) which strips the ligand right there in the receptor and delivers COB[II] which is used for both mitochondria and methylation locations. A characteristic of people with TCR deficiency is that the person can tell the difference between the 1 in 10 batches of MeCbl that will substitute functionally for COB[II] in methylation locations and AdoCbl can be used in mitochondria locations. I could distinguish the AdoCbl from the MeCbl and had separate distinguishable effects. If MeCbl varies for a person from 0 to 5 stars, then COB[II] is at least 6 stars, and when TCR is present in sufficient quantity to turn on CNS healing.
I am again speaking from experience. I learned how to generate/regenerate TCR. Prior to this I had never seen or known of anybody restoring TCR and B12 usage becoming more normal. I can no longer tell the difference between one batch of MeCbl and another or the difference of AdoCbl, they both become "6 star" COB[II]. I have experienced COB[II] startup 7 times in my life. The first 4 times gave me refeeding syndrome from hell, potentially nearly killing me as I had no idea what to do or manage it. Adelle Davis was right. Liver is a miracle food. It has all of the nutrients, at least 5 in a deadlock quintet,or more, of what the researchers were looking for in the liver concentrate as being "protein mystery factor". They assumed that a single item was their mystery factor. It wasn't and isn't.
So last I told you I was taking 10 mg subcutaneous injections 3 times a day and could tell the difference between 2 and 3 times a day. I was getting very little into the CNS and Cbl disappeared from it very quickly. This is a brute force way to get barely enough and barely good enough Cbl into the CNS for healing. It was a desperation from an almost non-working cobalamin system.
That dose of 30mg a day is 210 mg a week has kept me alive going face to face with copper deficiency and lots of damage from that and who knows what damages from other micronutrient metals deficiencies.
What I found was I had to take the whole group of micronutrient but not all together. Vitamin C in some quantities blocks copper absorption. Zinc interferes with copper and other micrometals absorption. Iron should be taken on lky if you need it and separately from all kinds of things and it interferes with a lot of things. Copper interfere with other micronutrients absorption. It took me 7 years to titrate the methylfolate and how it affects the multi compartment usage pattern, the paradoxical folate deficiency is a part of refeeding syndrome with bottlenecks. The 400-800 mcg dose for folic acid was thought to be safe. It isn't for me. Even a month of 45 mcg per day of folic acid was able to build up to a level it could block 45mg of Metafolin enough to makes various skin lesions.
It took 7 years for me to almost solve my copper situation and the pattern of serum falling with copper healing starting up by compartment doing more damage other than where it was healing.
All of these things and the rest of the micronutrients were required to be able to build TCR and possibly other micronutrient receptors. It wasn't easy to be able to absorb all the micronutrients.
Last August I had some fierce refeeding syndrome by going up to 7000 feet altitude starting red cell making, and it was the worst I ever have had at 7000 feet. It wasn't altitude sickness, it was refeeding going hypokalemia becasue of altitude. Since then I have been in managed refeeding syndrome.
The BIG change occurred in February, I had COB[II] neurological startup and it was immediately noticeable. It had turned off 4 years before, the 5 star MeCbl was no longer adequate.
NOW I am at 10 mg of MeCbl per week from 210 mg, and is working the BEST I have ever had and have caught up on the refeeding syndrome, bottleneck style, shortage of delivered item to where needed. I am still titrating dose and I am trying various patterns and durations and amounts but I may find that as I grow more TCR I might need only a mg per week or something. I don't know. It doesn't happen overnight. It takes specific ways to "encourage" the TCR to be grown.
I haven't tried any HyCbl yet. I can do that by exposing a syringe to light as I have in the past. If the TCR is fully operating as it should, the spoiled MeCbl ought to be as effective as MeCbl and not cause acne.
It was RichVank, who, in private conversations, told me he thought it was the micronutrients. He was right, and very complicated. I learned how to absorb and use the micronutrients to rebuild the TCR, intentionally as it wasn't happening accidently and I know of nobody who has done so. Copper was a major and complicated bottleneck and that had to be fixed before I could grow the TCR. As far as I know I need every one of the nutrients on the list and if my body doesn't produce COB[II] my body had enough good enough MeCbl to have healing in the CNS in order to grow the TCR in the CNS and it also stores the COB[II] in the TCR and it is out of the serum and not vulnerable to being excreted by the kidneys which is a very expensive way to do business, without protecting the B12.
With the TCR for the COB[II] to sit in it would theoretically protected from the glutathione. The amounts of B1, B2, B3 and P5P appear to drive some things and for whatever the reason my body has been very poor at maintaining equilibrium. P5P caused high hematocrit after my testosterone level went up by 25% when my copper came up off the bottom. It can get very messy. Also, as copper went up which L-carnitine I had to use changed. Also, for entirely unknown reasons I have to switch from Metafolin to Quatrefolic or back as each in turn loses effectiveness to the other. Now if you look at the specifics, they form a pattern of responses that indicates a specific pattern of symptoms and responses. Some people have the same pattern to the letter, others have quite different patterns,. each one as specifically repeatable by people who match the patterns when it is mapped. So your reasons for copper problems may be the same or different than mine. I have been tracking my patterns since 1978 and have learned mine very well. That's why it is criteria based titration and customized delivery and everything. Lots of [people match the folate., with low doses of methylfolate increasing the number of deficiency symptoms and seriousness while healing some. If a person isn't aware that folate can produce deficiency and healing in different parts of the body at the same time will NEVER figure it out. That comes from from research that notred the problem and nailed it down in the early 90s as "Paradoxical folate deficiency" in THE HORSE and a horse getting folic acid., some healing and some deficiency symptoms. Be well.
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