Many PwME complain of episodes of feeling as if they are running a fever although body temperature read by a thermometer is normal. I have these episodes. Often they are accompanied by chills exactly like one would experience with a high-grade fever. Other times I feel as if my body is hot, as if burning up with fever. Yet people who touch me say that I feel normal. Sometimes I will flush.
Both Dr. Susan Levine and Dr. Irma Rey told me they believe it is the virus reactivating (at least in my case). I don't know which virus, as I have elevated titers for non-active EBV, HHV6, and Parvovirus.
Now here is research from Dr Jarred Younger that measured the temperature of the brains of subjects with ME. During neuroinflmmation the heat cannot be taken away fast enough fro the brain. Could this explain why we often feel as if we are burning up or running a fever? Just my musings... what are your thoughts?
BTW, Younger et al say their 2019 findings indicate that ME/CFS involves neuroinflammation. Haven't we known that for a long time?
Brains are naturally hotter than the rest of our bodies.
Temperature in the brain rises when there is inflammation present, just like body temperature does during an infection.
Blood circulation acts to ‘cool’ the brain, by taking away ‘hot’ blood and replacing it with cooler, to tryand match the core body temperature.
During neuroinflammation, metabolic reactions are happening so quickly that more heat is being produced, meaning it is less easily taken away by the circulation, as it can’t keep up with the heat being produced.
Temperature in the brain rises when inflammation is present.
Build-up of heat in the brain can start to cause cognitive problems, balance problems and mood problems, which could explain some of the symptoms of ME/CFS.
Brain temperature is very sensitively controlled and so even a 1-degree difference would be enough to create symptoms.
https://www.meassociation.org.uk/wp...ests-brain-inflammation-in-MECFS-15.01.19.pdf
BTW I had this MRS done that is described in Younger's study. Mine was part of a clinical trial with Weil Cornell. The researcher NEVER interpreted my results and I have a CD with the images that none of my neurologists can make heads or tails of... thanks for that... much appreciated... very helpful... FML. DOES ANYONE KNOW WHERE I CAN HAVE THEM READ?
Both Dr. Susan Levine and Dr. Irma Rey told me they believe it is the virus reactivating (at least in my case). I don't know which virus, as I have elevated titers for non-active EBV, HHV6, and Parvovirus.
Now here is research from Dr Jarred Younger that measured the temperature of the brains of subjects with ME. During neuroinflmmation the heat cannot be taken away fast enough fro the brain. Could this explain why we often feel as if we are burning up or running a fever? Just my musings... what are your thoughts?
BTW, Younger et al say their 2019 findings indicate that ME/CFS involves neuroinflammation. Haven't we known that for a long time?
Brains are naturally hotter than the rest of our bodies.
Temperature in the brain rises when there is inflammation present, just like body temperature does during an infection.
Blood circulation acts to ‘cool’ the brain, by taking away ‘hot’ blood and replacing it with cooler, to tryand match the core body temperature.
During neuroinflammation, metabolic reactions are happening so quickly that more heat is being produced, meaning it is less easily taken away by the circulation, as it can’t keep up with the heat being produced.
Temperature in the brain rises when inflammation is present.
Build-up of heat in the brain can start to cause cognitive problems, balance problems and mood problems, which could explain some of the symptoms of ME/CFS.
Brain temperature is very sensitively controlled and so even a 1-degree difference would be enough to create symptoms.
https://www.meassociation.org.uk/wp...ests-brain-inflammation-in-MECFS-15.01.19.pdf
BTW I had this MRS done that is described in Younger's study. Mine was part of a clinical trial with Weil Cornell. The researcher NEVER interpreted my results and I have a CD with the images that none of my neurologists can make heads or tails of... thanks for that... much appreciated... very helpful... FML. DOES ANYONE KNOW WHERE I CAN HAVE THEM READ?