This may be totally out of the box, but has anyone considered vascular compression syndromes to be a part of this? I am finding that they are pretty rare (or severely misdiagnosed) and many doctors don't know a lot about them. Many with hEDS have Median Arcuate Ligament Syndrome (MALS), Nutcracker, Mals Thurner, etc. These are vascular compressions that affect blood flow to the organs, the heart, etc. Most patients with compressions have horrible fatigue. Those with connective tissue disorders can be born with their diaphragm lower than normal and this can lead to vascular compression problems as organs sort of float, droop lower. This drooping can cause artery and vein compressions, reducing blood flow often drastically. Compression disorders also compress and affect the nerves that go through the celiac plexus and other nerve bundles, including the vagus nerve. Compressions cause not only GI symptoms but also dysautonomia, POTS, chronic fatigue, severe pain, etc.
