Summary of NK and T cell discussions

Pyrrhus

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Since scientific studies on the lymphocytes called Natural Killer (NK) cells and CD8+ T cells in ME have provided conflicting results, I just wanted to start a thread to summarize in one place all discussions on this issue.

Hopefully, by listing all discussions in one place, it will be easier to see a bigger picture, if there is one.
(Note that CD8+ T cells are also called Cytotoxic T cells.)

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Discussions about lymphocytes such as NK cells or T cells:

Biomarkers in CFS: Natural Killer function (Fletcher/Klimas 2010)
https://forums.phoenixrising.me/thr...l-killer-function-fletcher-klimas-2010.11051/

Cytotoxic lymphocyte microRNAs as prospective biomarkers for CFS/ME (Brenu, Staines, Marshall-Gradisnik et al., 2012)
https://forums.phoenixrising.me/threads/new-phanu-study-on-microrna-markers.17324/

Longitudinal investigation of natural killer cells and cytokines in CFS/ME (Brenu, Staines, Marshall-Gradisnik et al., 2012)
https://forums.phoenixrising.me/thr...l-killer-cells-and-cytokines-in-cfs-me.16125/

Screening NK-, B- and T-cell phenotype and function in patients suffering from CFS. (Curriu et al., 2013)
https://forums.phoenixrising.me/thr...s-suffering-from-chronic-fatigue-syndr.22476/

Increased expression of activation antigens on CD8+ T lymphocytes in ME/CFS: inverse associations with lowered CD19+ expression and CD4+/CD8+ ratio, but no associations with (auto)immune, leaky gut, oxidative and nitrosative stress biomarkers (Maes et al., 2015)
https://forums.phoenixrising.me/thr...mphocytes-in-myalgic-encephalomyelitis.42118/

Unperturbed cytotoxic lymphocyte phenotype and function in ME/CFS patients (Theorell et al., 2017)
https://forums.phoenixrising.me/thr...ocyte-phenotype-and-function-in-me-cfs.52458/

Association of T and NK Cell Phenotype With the Diagnosis of ME/CFS (Rivas et al., 2018)
https://forums.phoenixrising.me/thr...e-diagnosis-of-me-cfs-rivas-et-al-2018.60032/

Longitudinal associations of lymphocyte subsets with clinical outcomes in CFS (Mehalick et al., 2018)
https://forums.phoenixrising.me/thr...-subsets-with-clinical-outcomes-in-cfs.57597/

Decreased Expression of the CD57 Molecule in T Lymphocytes of Patients with Chronic Fatigue Syndrome.(Espinosa, 2019)
https://forums.phoenixrising.me/thr...chronic-fatigue-syndrome-espinosa-2019.77241/

A systematic review of natural killer cells profile and cytotoxic function in ME/CFS (Eaton-Fitch et al. 2019)
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-1202-6

ME/CFS patients exhibit altered T cell metabolism and cytokine associations (Hanson et al. 2020)
https://forums.phoenixrising.me/thr...ytokine-associations-hanson-et-al-2020.79143/

...As well as this oldie-but-goodie:
Comparative Analysis of Lymphocytes in Lymph Nodes and Peripheral Blood of Patients with Chronic Fatigue Syndrome (Fletcher et al., 1999)
https://forums.phoenixrising.me/thr...analysis-of-lymphocytes-in-lymph-nodes.10697/
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I did do some reading into this. While my NHS blood results have never shown anything as being low or high, my lymphocytes definitely have come back low. However lymphocytes is a catch all for all immune cell types, so I don't see how that's helpful as it doesn't give a better proportion of what is low. Is there a good medichecks or UK based test for this? I was struggling to find one that will test for and show the different cell volume numbers. Instead of a number for lymphocytes on there own which seems a bit useless.

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godlovesatrier

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