Longitudinal associations of lymphocyte subsets with clinical outcomes in CFS

pattismith

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Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome

Melissa L. Mehalick
, Karen B. Schmaling, Daniel E. Sabath & Dedra S. Buchwald
Received 26 Aug 2016, Accepted 08 Jan 2018, Published online: 12 Jan 2018

ABSTRACT
Background: Chronic fatigue syndrome (CFS) is characterized by prolonged fatigue and other physical and neurocognitive symptoms. Some studies suggest that CFS is accompanied by disruptions in the number and function of various lymphocytes. However, it is not clear which lymphocytes might influence CFS symptoms.

Purpose: To determine if patient reported fatigue symptoms and physical functioning scores significantly changed across time with lymphocyte counts as evidence of a relation among chronic fatigue symptoms and the immune response.

Methods: The current longitudinal, naturalistic study assessed the cellular expression of three lymphocyte subtypes – natural killer (NK) cells (CD3 − CD16+ and CD3 − CD56+) and naïve T cells (CD4 + CD45RA+) – to determine whether changes in lymphocytes at 4 time points across 18 months were associated with clinical outcomes, including CFS symptoms, physical functioning, and vitality, among patients with chronic fatigue. Latent growth curve models were used to examine the longitudinal relationship between lymphocytes and clinical outcomes.

Results: Ninety-three patients with Fukuda-based CFS and seven with non-CFS fatigue provided study data. Results indicated that higher proportions of naïve T cells and lower proportions of NK cells were associated with worse physical functioning, whereas higher proportions of NK cells (CD3 − CD16+) and lower proportions of naïve T cells were associated with fewer CFS symptoms.

Conclusion: These findings suggest that lymphocytes are modestly related to clinical outcomes over time
 
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Nice paper, wonder about the effect sizes though. I also think that time scale if crappy. I want people to study 48 hours of PEM. It's like measuring the tide - you need to watch it closely to learn!


(Little tip @pattismith . These seem to show up in the 'new posts' section only if you comment on your own post after posting it!)
 

Sushi

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These seem to show up in the 'new posts' section only if you comment on your own post after posting it!)
Anything you post will show up in "New Posts"--for other members, but not for yourself as it is not "new to you." You can see a post you made, however, by clicking on "Recent Posts." The thread will show again in "New Posts" for the opening poster as soon as someone else posts on the thread.