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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Poll: Mast cell and histamine degradation genotypes

Which of the following SNPs are atypical in your case?

  • KIT: rs121913507 / i5007903 (A > T)

    Votes: 0 0.0%
  • IL13: rs1800925 (C > T)

    Votes: 0 0.0%
  • IL4R: rs1801275 (G > A)

    Votes: 1 33.3%
  • FCER1A: rs2298805 (G > A)

    Votes: 0 0.0%
  • FCER1A: rs2251746 (T > C)

    Votes: 0 0.0%
  • FCER1A: rs2427827 (C > T)

    Votes: 2 66.7%
  • CMA1: rs1800875 (C > T)

    Votes: 0 0.0%
  • PTPN22: rs2476601 (G > A)

    Votes: 1 33.3%
  • IL33: rs1342326 (C > A)

    Votes: 2 66.7%
  • IL33: rs3939286 (C > T)

    Votes: 1 33.3%
  • IL33: rs928413 (A > G)

    Votes: 1 33.3%
  • ALDH2: rs671 (G > A)

    Votes: 0 0.0%
  • PTGS2: rs4140564 (A > G)

    Votes: 0 0.0%
  • AOC1: rs10156191 (C > T)

    Votes: 2 66.7%
  • AOC1: rs2052129 (G > T)

    Votes: 1 33.3%
  • AOC1: rs1049742 (C > T)

    Votes: 0 0.0%
  • AOC1: rs1049793 (C > G)

    Votes: 1 33.3%
  • HNMT: rs1050891 (G > A)

    Votes: 2 66.7%
  • HNMT: rs11558538 / i3000469 (C > T)

    Votes: 0 0.0%
  • Other pathological SNP or significant genotype

    Votes: 1 33.3%
  • 0 atypical SNPs

    Votes: 0 0.0%
  • 1-2 atypical SNPs

    Votes: 0 0.0%
  • 3-5 atypical SNPs

    Votes: 2 66.7%
  • 6-9 atypical SNPs

    Votes: 0 0.0%
  • 10 or more atypical SNPs

    Votes: 0 0.0%

  • Total voters
    3

nerd

Senior Member
Messages
863
I know that there has been one poll on how frequently MCAS co-exists with CFS/ME.

But I could imagine that some of the negative cases just are not perceived as MCAS when, in fact, the mast cells might still be dysregulated asymptomatically. This is why I would prefer to describe the condition as mast cell dysregulation.

I hope to find more answers to this in this poll.

I pulled a list of relevant SNPs and genes from Genetic Lifehacks.

Please only select the SNPs that are atypical. If there are significant or pathological SNPs in your respective genes that I don't mention, please tick "Other SNP" and describe it in the comments. In case there should be a pattern among those, I can extend the survey.

Thanks for your contribution.
 

nerd

Senior Member
Messages
863
These are additional SNPs that might be significant, in case you share these:
  1. IL13: rs20541 (A > G)
  2. IL4R: rs1805010 (A > G)
  3. CMA1: rs5246 (G > C)
  4. CMA1: rs5248 (A > G)
  5. CMA1: rs5249 (C > A)
  6. PTPN22: rs57877024 (AT > A)
  7. PTGS2: rs5277 (G > C)
  8. AOC1: rs2071514 (G > A)
  9. AOC1: rs10893 (A > G)
  10. AOC1: rs1049748 (T > C)
  11. AOC1: rs6943147 (C > G)
  12. AOC1: rs6943420 (G > C)
  13. AOC1: rs12179 (G > A)
  14. AOC1: rs1049793 (C > G)
 
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