• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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genome

  1. Countrygirl

    DecodeME: Take Part in the World's Largest Genetic Study into ME

    https://www.theguardian.com/society/2020/jun/23/uk-to-launch-genetic-study-chronic-fatigue-syndrome-cfs?fbclid=IwAR2H9ZG1-BBZzu2KCOefscZKuCca9AfIGslXjWLpfgpSi49S9VotmMcglJE
  2. Pyrrhus

    Genetic and Genomics Studies in ME

    I thought I'd start a thread to collect together the various genetic and genomics studies in ME. Please feel free to post any relevant genetics or genome studies.
  3. nerd

    Poll: Mast cell and histamine degradation genotypes

    I know that there has been one poll on how frequently MCAS co-exists with CFS/ME. But I could imagine that some of the negative cases just are not perceived as MCAS when, in fact, the mast cells might still be dysregulated asymptomatically. This is why I would prefer to describe the condition...
  4. nerd

    POLL: CC allele in rs9557195

    Considering the causal significance of herpes-viral infections, especially EBV, I'd be interested in the prevalence of the CC allele in CFS/ME patients (10.1111/bph.15395). This SNP determines the EBI 2 expression on lymphocytes and EBI 2 is a key pathogenic post-viral driver, though it...
  5. percyval577

    Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in ME/CFS: A Pilot Study. Perez et al 2019

    Link to the Study Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study Melanie Perez1, Rajeev Jaundoo2,3, Kelly Hilton1, Ana Del Alamo1,3, Kristina Gemayel1, Nancy G. Klimas1,3,4, Travis J. A...
  6. E

    High rate of false positives and misinterpretation of SNPs characterize direct-to-consumer genetic testing

    From Nature, Genet Med. 2018 Mar 22. doi: 10.1038/gim.2018.38. [Epub ahead of print] False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care. Full text here.
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