Genetic risk factors of ME/CFS: a critical review (Dibble et al., 2020) https://academic.oup.com/hmg/article/29/R1/R117/5879704
"Here we critically review existing evidence that genetic factors alter ME/CFS risk before concluding that most ME/CFS candidate gene associations are not replicated by the larger CFS cohort within the UK Biobank."
Genetics Study on ME - Decode ME (2021) https://forums.phoenixrising.me/threads/genetics-study-on-me-decode-me.85204/
An ambitious Genome-Wide Association Study (GWAS) called DecodeME, led by Dr. Chris Ponting, will seek to look at a very large number of patients to answer unresolved questions regarding possible genetic contributions to ME. Whereas DecodeME will focus on looking for common genetic variants, a separate study by the UK Biobank looked for uncommon genetic variants in self-reported CFS patients. DecodeME issues a commentary on the UK Biobank study. The UK Biobank study can be found here: https://www.nature.com/articles/s41586-021-03855-y
In this study, we have analyzed three ME/CFS cohorts: a Norwegian discovery cohort (N=427), a Danish replication cohort (N=460) and a replication dataset from the UK biobank (N=2105). To the best of our knowledge, this is the first ME/CFS genome-wide association study of this magnitude incorporating 2532 patients for the genome-wide analyses and 460 patients for a targeted analysis. Even so, we did not find any ME/CFS risk loci displaying genome-wide significance.