Genetic and Genomics Studies in ME

Pyrrhus

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Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study (Perez et al., 2019)
https://forums.phoenixrising.me/thr...-me-cfs-a-pilot-study-perez-et-al-2019.76400/
A genomics pilot study from the team of Nancy Klimas and Lubov Nathanson, using 23andME data provided by patients.


Re-analysis of Genetic Risks for Chronic Fatigue Syndrome From 23andMe Data Finds Few Remain (Bedford and Tzvoras, 2021)
https://www.frontiersin.org/articles/10.3389/fped.2021.590040/full
A critical re-analysis of the above (Perez et al., 2019) pilot study finds problems.



Genetic risk factors of ME/CFS: a critical review (Dibble et al., 2020)
https://academic.oup.com/hmg/article/29/R1/R117/5879704
"Here we critically review existing evidence that genetic factors alter ME/CFS risk before concluding that most ME/CFS candidate gene associations are not replicated by the larger CFS cohort within the UK Biobank."



Genetics Study on ME - Decode ME (2021)
https://forums.phoenixrising.me/threads/genetics-study-on-me-decode-me.85204/
An ambitious Genome-Wide Association Study (GWAS) called DecodeME, led by Dr. Chris Ponting, will seek to look at a very large number of patients to answer unresolved questions regarding possible genetic contributions to ME. Whereas DecodeME will focus on looking for common genetic variants, a separate study by the UK Biobank looked for uncommon genetic variants in self-reported CFS patients. DecodeME issues a commentary on the UK Biobank study. The UK Biobank study can be found here: https://www.nature.com/articles/s41586-021-03855-y
 
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Pyrrhus

Senior Member
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Last edited:

Pyrrhus

Senior Member
Messages
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12,320
Location
U.S., Earth
Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci (Hajdarevic et al., 2022)
https://forums.phoenixrising.me/thr...al-potential-ris-hajdarevic-et-al-2022.87325/

In this study, we have analyzed three ME/CFS cohorts: a Norwegian discovery cohort (N=427), a Danish replication cohort (N=460) and a replication dataset from the UK biobank (N=2105). To the best of our knowledge, this is the first ME/CFS genome-wide association study of this magnitude incorporating 2532 patients for the genome-wide analyses and 460 patients for a targeted analysis. Even so, we did not find any ME/CFS risk loci displaying genome-wide significance.