It is interesting to hear talk about similarities with HIV/AIDS because AIDS patients are constantly fighting pathogens and they are helped with antiretrovirals - which is the opposite of what this study's authors are proposing. Being that they are constantly attacked, I would assume that HIV/AIDS patients are in a hypermetabolic state.
Some of us have retroviruses, but not like HIV, we have activated HERV's that, presumably, are associated to the autoimmunity , relatively recently discovered, in CFS + POTS and I've had the tests myself, which are also positive (I don't trust research claims blindly in a heterogenous diagnosis and test myself when possible). How this ties in with the Metabolic defect I have no idea..yet. I can only reference one paper at the moment, but the big one is meant to be coming out this year or next:
Here's a first (tiny) study with only 12 ME patients, positive at 66%, but interesting none the less considering the official line is we need to stop thinking about infections and do more exercise!
''In eight out of 12 individuals with ME, immunoreactivity to HERV proteins was observed in duodenal biopsies. In contrast, no immunoreactivity was detected in any of the eight controls''.
Source: In Vivo. 2013 Mar-Apr;27(2):177-87.
Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins.
De Meirleir KL1, Khaiboullina SF, Frémont M, Hulstaert J, Rizvanov AA, Palotás A, Lombardi VC.
Why am I mentioning infection on a Mitochondria test thread? Because of the endless amount of people you will find online with a diagnosis of ME, CFS, Chronic Lyme (3 disputed conditions), all reporting that when they test via LTT/Elispot, they have positive results for Chronic Intracellular Infection.
Why do I want to share this rambling of mine with you and others? Because not only does Cpn cause 'Chronic Fatigue', it can also be associated to worsening of Asthma, Heart Failure and Cancer etc, in it's chronic intracellular form where simple antibiotics won't work (like Lyme). The drugs won't work as it has no cell wall to target.
So yea, chronic infections are not only prevalent n ME CFS Lyme (whatever you want to call it) when not relying on serology (antibodies), they are also contributing to further ruining our lives. when we are already really ill to begin with. Hence it's critical we focus on pathogens, when we are riddled with chronic immune activation, ATP loss, inflammation and autoimmunity,
Check this out from the past (the past in Science is very important in research to find links to the present):
''Heatshock protein 60 (hsp60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins''.
Source: Nature. 1990 Nov 29;348(6300):455-8.
The mitochondrial chaperonin hsp60 is required for its own assembly.
Cheng MY1, Hartl FU, Horwich AL.
''The heat-shock protein hsp60 is typically found in mitochondria''
Source: Mol Immunol. 1999 Jun;36(9):619-28.
A 60 kD heat-shock protein-like molecule interacts with the HIV transmembrane glycoprotein gp41.
Speth C1, Prohászka Z, Mair M, Stöckl G, Zhu X, Jöbstl B, Füst G, Dierich MP.
OK, so HSP is usually found inside Mitochondria. Which makes us remember this from 3 years ago.....
When evaluated with 61 other ME and 399 non-ME samples (331 BD, 20 Multiple Sclerosis and 48 Systemic Lupus Erythematosus patients), a peptide from Chlamydia pneumoniae HSP60 detected IgM in 15 of 61 (24%) of ME, and in 1 of 399 non-ME at a high cutoff (p<0.0001). IgM to specific cross-reactive epitopes of human and microbial HSP60 occurs in a subset of ME, compatible with infection-induced autoimmunity''.
Source:
PLoS One. 2013 Nov 28;8(11):e81155. doi: 10.1371/journal.pone.0081155. eCollection 2013.
Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.
Elfaitouri A1, Herrmann B, Bölin-Wiener A, Wang Y, Gottfries CG, Zachrisson O, Pipkorn R, Rönnblom L, Blomberg J.
Question we should all consider. As ME CFS doesn't have a test, when there is an evidence based test (potentially the Metabalon Metabolic one we are all discussing), does the percentage in the paper above, go up? And if so, by how much. It might stay level, it may soar up to 80%.
And the next question, what (if any)
other infections (bacterial, viral, mycoplasmas, retroviral) can cause this proposed '
'Infection Induced Autoimmunity' that Blomberg et al, discovered in 1 in 4 PWME, using no diagnostic test to confirm ME...as well?
If we start having a pathogen party, or should I say bacterial, I want to see the test results of patients with and without these chronic intracellular infections, and compare the differences to our 'scores' on the proposed Metabalon test, and the future Autoimmune tests, if any.
her basement smells mildew and I cant even stay the night there because it bothers me, this illness has tore my family apart in so many ways, when will the suffering end! 20 some years now that I've missed out of family stuff, I'm basicly a stranger now 
