@Freddd
Gotcha. Thank you for the explanation. 1 more question regarding folic acid though. I also recently tested a multi that used 120mcg of combined methylcobalamin and cyanocobalamin and 400mcg folic acid, all junk except the tiny amount of methylcobalamin. But here’s the kicker, my muscles loosened up, my angular cheilitis started healing, I slept great, but, I was exhausted all the time, had a really tough time gettin out of bed and short term memory was terrible. Can you explain why half of my symptoms immediately got better but created new ones?
I also tried an extra 400mcg methylfolate this afternoon (probably hit 1mg by that time) and now feel very detached from everything, having a hard time comprehending your posts and talking to people, feel spaced out. Is this the donut hole? Took some but not enough?
Hi GreenMachineX,
The original list for the N=1000 questionnaire study I did with a single 1000 mcg sublingual MeCbl used for 1 hour during the interview, used all English lists from around the world I could find of B12 symptoms. Then something like "peripheral neuropathies" was given a multitude of all the symptoms of said neuropathies for progressive detail. Then there were all the symptoms people reported in variations, all the distinctions they made or I made (10 or so different neuromuscular pains. Then I kept track of all my symptoms and those of some others that responded to MeCbl and basics.or in studies, just plain MeCbl. I eliminated all the symptoms that didn't respond to the MeCbl and other nutrients, grouped them in order of responses and combinations and this list are all symptoms that responded to MeCbl, MeCbl and Metafolin(methylfolate) and so on. I only have the first two groups here, what we are talking about.
I had about 80-90% of the symptoms listed, 200 in all that responded over the years.
This is a list of symptoms that are mine, and others experience of these nutritional items in relieving their symptoms, and in a very few instances reflect research and successful practice, such as p5p for Hcy and Liver extract studies of several disorders in old journals. In some instances the same symptoms might have different combinations and order of nutrients. There are redundancies. Some people are going to report what the doctors said. Some described it the way they experienced it. The importance was getting a response. People might say "no" to neuropathies of feet and same person say "yes" to burning feet, electrical feeling jolts to feet, severe tingling and so on.
"Can you explain why half of my symptoms immediately got better but created new ones?"
That is easy. I started responding in 5 minutes. Within an hour me, and hundreds of other people from the study, had dozens of symptoms affected in that first hour. I did the study becasue I HAD TO KNOW if my immediate response was normal or unusual. It was normal. 75% of the people with large numbers of at least some of the groups of symptoms responded to MeCbl within one hour, and later in a small redo with MeCbl and Metafolin I had the same results. 80+% responded even more to those two things inside an hour. The small dose of Metafolin, 800 mcg, caused folate deficiency refeeding syndrome in most everybody having both the response symptoms and dozens of blossoming folate deficiency symptoms.
"I also tried an extra 400mcg methylfolate this afternoon (probably hit 1mg by that time) and now feel very detached from everything, having a hard time comprehending your posts and talking to people, feel spaced out. Is this the donut hole? Took some but not enough?"
Yes, some but not enough. Now if you took 4mg 3 or 4 times in a day, you likely wouldn't have most of the refeeding syndrome deficiency symptoms come out. They show up as soon as they are challenged to get past that folate point in the cell making. There is virtually no effective nutrient that I have taken that hasn't shown up in 5 minutes (MeCbl) to 4 hours (copper). On the 3rd day of continuation you would get potassium refeeding symptoms. I was prepared for the potassium from studies. Not ONE of the studies mentioned refeeeding symptoms. They had no idea. I titrated slowly,suffered extremely and eventually solved it. Instead they listed those things as side effects. However, since Metafolin wasn't tested with MeCbl, the studies had very little cell building done.
The "lights came on" for me in 20 minutes. Depression of decades cleared. I walked all the way up the stairs without stopping after one hour.for the first time in years.I had energy I had never had before, but no muscle capacity. I didn't notice much in refeeding symptoms as I already had all of them. On this list the 7 years it took for some of the folate symptoms was becasue I didn't take enough until 7 years. I got rid of my last folate deficiency high MCV after 13 years becasue that is when the dose got up to the necessary 45mg. On the meCbl the 9 months was how long it took me to titrate to equilibrium at 10mg sublingually daily, about 2.5 mg absorbed according to my urine colorimetry tests.
I hope this answers your questions, if not, ask.
Extracted from
https://www.quora.com/Has-someone-u...7?__filter__=&__nsrc__=2&__snid3__=3020697146
These symptoms responded almost entirely or entirely with basics 5 star MeCbl – methylcobalamin – Methylb12 - Mb12 - Mecobl . Many started improving in hours. Others took 9 months to correct.
morning joint stiffness and pain
paleness
acid reflux
nausea
daily vomiting
standing with eyes closed, lose balance
hands feel gloved with loss of sensitivity - glove anesthesia
feet feel socked by loss of sensitivity - stocking anesthesia
glove and stocking anesthesia
neuropathic bladder
unable to release bladder, mild to severe
unable to fully empty the bladder
fecal incontinence - occasionally to frequently
diminished hearing - gradual onset or present for life, sudden return possible
tinnitus - ringing in ears
always feeling cold
intolerance to loud sounds
intolerance to multiple sounds
sleep disorders
non restorative sleep
Night terrors
Prolonged hypnagogic or hypnopompic states transitioning to/from sleep
Sleep paralysis
alteration of touch all over body, normal touch can be unpleasant and painful
alterations and loss of taste
taste hallucinations
smell hallucinations
sound hallucinations
visual hallucinations
alterations and loss of smell
loss of smell and taste of strawberries specifically
loss or alteration of smell and taste of potato chips specifically
roughening and increased raspiness of voice, mb12 can smooth it in mid word
blurring of vision - can be sudden onset and sudden return
Visual impairment can be seen; ophthalmological exam may show bilateral visual loss
optic atrophy
centrocecal scotomata
hypersensitivity/intolerance to bright light
intolerance to loud sounds
intolerance to multiple sounds
burning muscle pain
diminished hearing - gradual onset or present for life, sudden return possible
tinnitus - ringing in ears
sore burning tongue
These symptoms responded strongly first to 5 star MeCbl and then Metafolin with basics. Many started improving in hours. Some took 7 years to correct.
Bursitis
stomach not emptying
frequent vomiting
acid regurgitation
dyspepsia
flatulence
altered bowel habits
abdominal pain
loss of appetite for meat, fish, eggs, dairy, the only b12 containing foods
nutrient specific anorexia
intermittent constipation
intermittent diarrhea
irritable bowel syndrome
sores, ulcers and lesions along entire GI tract or any part
anorexia
Bulimia
Hypersensitivity to touch
Hypersensitivity to odors
Hypersensitivity to tastes
Hypersensitivity to clothing texture
Hypersensitivity to body malfunctions, symptoms
Hypersensitivity to sounds and noises
Hypersensitivity to light and visual stimuli
Hypersensitivity to blood sugar changes
Hypersensitivity to internal metabolic changes
Hypersensitivity to temperature changes
burning bladder (no UTI)
painful urgency (no UTI)
burning urethra (no UTI)
Low blood serum level - below 550pg/ml, Japanese Standard
elevated MCH (Mean Corpuscular Hemoglobin)
elevated LDH
big fat red cells (when said this way usually with happy or healthy modifying it completely misinterpreting results of MCV
platelet dysfunction, low count
white cell changes, low count
hyper segmented neutrophils
headaches
inflamed epithelial tissues - mucous membranes, skin, GI, vaginal, lungs
inflamed endothelial tissues - lining of veins and arteries
mucous becomes thick, jellied and sticky
asthma
chronic cough that mimics asthma but isn't
chronic sinus congestion
dermatitis herpetiformis, chronic intensely burning itching rash
frequent infected follicles or acne type lesions all over body
chronic infections, many varieties possible
Seborrhic dermatitis
dandruff
eczema
dermatitis
skin on face, hands, feet, turns brown or yellow if anemia occurs
poor hair condition
thin nails
transverse ridges on nails, can happen as healing starts
mouth sensitive to hot and cold
sore burning tongue
beef-red tongue, possibly smoother than normal
sore mouth, no infection or apparant reason
teeth sensitive to hot and cold
canker sores