HHV-6/EBV testing UK? / Remitting symptoms on Molnupiravir?

[FoxgloveFever]

My understanding is that molnupiravir only works for RNA viruses, and has broad-spectrum activity against RNA viruses. It does not work for DNA viruses such as the herpesviruses (EBV, HHV-6, cytomegalovirus, etc).

So I guess molnupiravir might potentially work for like enteroviruses (coxsackievirus B and echovirus), which like SARS-CoV-2 are RNA viruses. These enteroviruses have long been linked to ME/CFS.

Unfortunately testing for coxsackievirus B and echovirus is not straightforward, as there are only a few labs which offer the suitably sensitive antibody neutralisation test that Dr Chia recommends for testing chronic enterovirus infections in ME/CFS.

Thank you. This is all really useful information.

 

[Hip]

Thank you. This is all really useful information.

More information about the specific tests used by ME/CFS doctors for each ME/CFS virus is found in this Viral Testing in ME/CFS article.


One thing to bear in mind is that it might not have been the molnupiravir which put you into remission; it could have been the acute COVID infection which did that. The theory is that the immune activation from fighting COVID might also clear other ME/CFS viruses at the same time.

Or it might have been the combination of the immune activation from the COVID infection plus the drug which cleared your other ME/CFS viruses.

If you look at this poll on what happened to existing ME/CFS patients when they caught COVID, result show about of existing patients 40% had no long-term change to their health level; another 35% got permanently worse; but around 10% actually got permanently better after acute COVID.

So COVID can sometimes permanently improve ME/CFS.


This reddit report details another existing ME/CFS patient who took molnupiravir for an acute COVID infection and got much better for a month, before slowly relapsing back into ME/CFS.

 

[FoxgloveFever]

More information about the specific tests used by ME/CFS doctors for each ME/CFS virus is found in this Viral Testing in ME/CFS article.


One thing to bear in mind is that it might not have been the molnupiravir which put you into remission; it could have been the acute COVID infection which did that. The theory is that the immune activation from fighting COVID might also clear other ME/CFS viruses at the same time.

Or it might have been the combination of the immune activation from the COVID infection plus the drug which cleared your other ME/CFS viruses.

If you look at this poll on what happened to existing ME/CFS patients when they caught COVID, result show about of existing patients 40% had no long-term change to their health level; another 35% got permanently worse; but around 10% actually got permanently better after acute COVID.

So COVID can sometimes permanently improve ME/CFS.


This reddit report details another existing ME/CFS patient who took molnupiravir for an acute COVID infection and got much better for a month, before slowly relapsing back into ME/CFS.

No, that's also me, not another patient. I will check out those links though. Thank you for the info.

 

[Hip]

There have been some concerns that molnupiravir might have a degree of carcinogenity.

However, I just came across more recent studies which suggest that molnupiravir is not carcinogenic:

Giving mice molnupiravir continuously for 6 months did not increase cancer rates.

The Ames test for genotoxicity found no genotoxic effects from molnupiravir.



So if molnupiravir is safe to use, and if a 5-day course of molnupiravir results in a month or two's remission from ME/CFS symptoms, then conceivably it may be safe to take regular courses of molnupiravir every month or two to maintain remission.

Molnupiravir is not expensive: a 5-day course of generic molnupiravir can cost as little as $55 at prescription-free overseas pharmacies:

Molnupiravir Sources:
https://www.buy-pharma.md/Products/search?keyword=Molnupiravir
https://www.safegenericpharmacy.com/molnupiravir-capsules
https://www.drugssquare.com/?s=Molnupiravir&post_type=product&product_cat=0
https://www.purchase-prep.com/product/molnunat-200-generic-molnupiravir/

 

[godlovesatrier]

Thanks for posting this. This is really quite reassuring. I've taken it three times now. The first time my ME improved so much I was able to travel for the first time in years. The Pfizer jab undid the massive improvement.

Second time I had acute covid so there wasn't a Lott or report as I got long covid after that.

Third time I took it three weeks post COVID due to a nasty crash which I had a suspicion was due to an ev+ COVID not just COVID. When I took that dose I experienced improvement about a day after I ended my course. I've not had any malaise physical fatigue or very bad weakness so far. Assuming I don't crash in the next few days I think it was a success.

The point here is it's the only thing that's improved my ME and studies have shown that viruses are not capable of becoming resistant to it. Which is reassuring.

I've also had problems with my hands and back and I could feel molnu attacking something in my muscles and nerves into my hand and arms when I was taking it. This contrasts to the first two times where I did not have these symptoms and did not experience the sensation either when taking it.

It hasn't done anything for my noise sensitivity but maybe a proper dose would. Sadly it generates a hell of a lot of variants they've recently proven this as well in a new study. It's something like 4 new COVID variants a day for every day of molnu you take. Whether this proves to be bad or not is hard to say. I can only assume it would be the same with an ev.

 

[FoxgloveFever]

There have been some concerns that molnupiravir might have a degree of carcinogenity.

However, I just came across more recent studies which suggest that molnupiravir is not carcinogenic:

Giving mice molnupiravir continuously for 6 months did not increase cancer rates.

The Ames test for genotoxicity found no genotoxic effects from molnupiravir.



So if molnupiravir is safe to use, and if a 5-day course of molnupiravir results in a month or two's remission from ME/CFS symptoms, then conceivably it may be safe to take regular courses of molnupiravir every month or two to maintain remission.

Molnupiravir is not expensive: a 5-day course of generic molnupiravir can cost as little as $55 at prescription-free overseas pharmacies:

Molnupiravir Sources:
https://www.buy-pharma.md/Products/search?keyword=Molnupiravir
https://www.safegenericpharmacy.com/molnupiravir-capsules
https://www.drugssquare.com/?s=Molnupiravir&post_type=product&product_cat=0
https://www.purchase-prep.com/product/molnunat-200-generic-molnupiravir/

Thank you. This is so so helpful and much appreciated.

 

[FoxgloveFever]

Thanks for posting this. This is really quite reassuring. I've taken it three times now. The first time my ME improved so much I was able to travel for the first time in years. The Pfizer jab undid the massive improvement.

Second time I had acute covid so there wasn't a Lott or report as I got long covid after that.

Third time I took it three weeks post COVID due to a nasty crash which I had a suspicion was due to an ev+ COVID not just COVID. When I took that dose I experienced improvement about a day after I ended my course. I've not had any malaise physical fatigue or very bad weakness so far. Assuming I don't crash in the next few days I think it was a success.

The point here is it's the only thing that's improved my ME and studies have shown that viruses are not capable of becoming resistant to it. Which is reassuring.

I've also had problems with my hands and back and I could feel molnu attacking something in my muscles and nerves into my hand and arms when I was taking it. This contrasts to the first two times where I did not have these symptoms and did not experience the sensation either when taking it.

It hasn't done anything for my noise sensitivity but maybe a proper dose would. Sadly it generates a hell of a lot of variants they've recently proven this as well in a new study. It's something like 4 new COVID variants a day for every day of molnu you take. Whether this proves to be bad or not is hard to say. I can only assume it would be the same with an ev.

Thank you for sharing your story. It's good to hear how other people have reacted.
I had read that it can generate variants, but surely this is only an issue if one doesn't self-isolate whilst taking molnu? If it generates variants but no one else is around to catch them, surely they just die off?

 

[godlovesatrier]

That's not how it works. It generates 4 per day and that has lead to the number of variants we have in the world. I also believe transmission is often asymptomatic.

So no those variants can be alive and well in your body when you next get COVID. It's unclear what effect boosters have on them.