Eosinophils and their role in Connective Tissue Disorders, Autonomic Dysfunction, and Mast Cell interactions.

Do you have an Eosinophilic Disorder?

  • Yes

    Votes: 5 71.4%
  • No

    Votes: 2 28.6%

  • Total voters
    7

Jwarrior77

Senior Member
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There has been increasing research on the role of eosinophils and connective tissue disorders. The eosinophils main role is fighting off parasitic infections, however they also play a huge part in allergic responses and inflammation. They release many cytotoxic and neurotoxic chemicals that damage foreign invaders but also your own cells / tissue.

I'm doing more research into this and may post on other threads the more I find out. Let me know if anyone else has any info on eosinophils and their roles specifically in EDS, POTS, ME/CFS, and MCAS. Also if your eosinophils ever consistently came back high on blood tests. Thanks.

Here are some studies:

High prevalence of eosinophilic esophagitis and connective tissue disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807809/
High ECP found in CFS patients: https://pubmed.ncbi.nlm.nih.gov/8738520/
On their prevalence in autonomic dysfunction / POTS: https://pubmed.ncbi.nlm.nih.gov/30851172/
Eosinophil interaction with Mast Cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083463/
Eosinophilic gastrointestinal disorders and autoimmune connective tissue disease: https://pubmed.ncbi.nlm.nih.gov/26709253/
Eosinophilic Vasculitis in connective tissue disease: https://pubmed.ncbi.nlm.nih.gov/8708015/
Eosinophils in their role of tissue remodeling: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808957/
 
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Jwarrior77

Senior Member
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I don’t know if I have an eosinophil disorder but the one time they were measured they were high
If due to low pyruvate the red blood cell wall hardens could the eosinophils be attacking this
My Eosinophils have come up only slightly high on a couple CBCs but not all of them. It wasn't anything bad enough to alert doctors. Most of the time it's normal. However its come to my knowledge that people could still have problems with eosinophils even if they come back normal or slightly elevated. It's similar to how people can come back negative for MCAS but still have MCAS.

I'm going to be getting an Eosinophil Cationic Protein test to more accurately determine if the Eosinophils are releasing their toxic chemicals into my blood stream. It's the same test in the link where ECP was found elevated in some CFS patients.
 
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judyinthesky

Senior Member
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@Jyoti I have none of those
But this has always been the only thing off in my health history for a long long time
I have hyperhydrosis on hands and feet and as my doctors said could be allergy put it down to that. What do you mean with unidentified? Why do you think you have it?
Also was it relative or absolute eosinophils?
 

Jyoti

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Also was it relative or absolute eosinophils?
That is a good question. In my case.....absolute. Yours is relative?

Makes a little sense as to the hyperhydrosis/allergy possibility. Interesting that high eosinophils are the only thing that comes back abnormal.

What do you mean with unidentified? Why do you think you have it?
My family has a lot of connective tissue disorders including a very rare syndrome particularly effecting the vascular systems, including early death and cognitive loss. Similar to but not Loeys-Dietz. I've had multiple dislocations, AAI, and score pretty high on the Beighton scale, but all I've ever gotten in terms of diagnosis is 'unspecified hyper mobility syndrome."