Hi Fred,
I know that one will get a pink/dark tinged urine with methyl b12 injections, but does taking it S.L. produce that also. I thought I read something in all this info where you mentioned something about checking the color of urine after taking it SL.
Is the excess what one would see in the urine past a methyl b12 injection? Is that why you split your injections into 4 per day?
Thanks.
Deb
Hi Deb,
Sublingual tablets in usual amounts doesn't normally cause any perceivable difference in coloring. If it does a person is possibly critically short of methylfolate.
It is amount related. I'll explain.
The serum half life of b12, any b12, if injected is about 20-50 minutes right off the bat. That means that the serum level drops by 50% in about 30 minutes or so. By the time one reaches 12 hours after dose that is down to about 4 hours serum half life. From 12-48 hours it averages 12.9 hours serum halflife.
A 2000mcg IM injection is fully dispersed into the blood within 30 minutes and drops like a rock. 90 minutes after injection about 1/4 remains. The urine collected over that time MIGHT show some b12 coloration but very minimal, likely only as a slight darkening of the yellow or a slight (Just Noticable Difference) magenta color if otherwise colorless.
To get 2000mcg into the serum in 90 minutes with sublinguals would require about 3 or 4 sublinguals 5mg all at the same time. Depending upon folate status one might see a JND of magenta.
When one performs the 50mg challange test for CNS/CSF penetration taking 10 x 5mg mb12 in 2 hours saturating the mouth which equals approximately a 7.5mg subcutaneous injection in performance, one could expect to see a slight coloration, perhaps 2 or 3 JNDs, again depending upon the persons folate status.
It normally happens only once per dose and is already being extracted by the kidneys even as you have them in your mouth.
The SC injection spreads the absorbtion out over more than 12 hours but MOST of it is in the first 3-4 hours.
The reason I take 3 x 10mg or 4 x 7.5mg injections per day is that it produces a more even serum level above the threshold I need to get CNS/CFS penetration. 30mg all at once would make for very notiocable urine coloration for 6 hours but doen't produce the same healing effect as the more frequent dosing. Unfortunatley I have to have that high dose and frequent schedule to stop nerological deterioration and reverse it. Fortuantely it works or I would be in a wheelchair. Most folks don't have that extreme a need. That is what the 50mg challange dose is about.