Hi Rich,
The issue with TMG you have noted here, does this mean we should not take TMG?
and isn't that in you protocol re the actifolate?
***There is a small amount of TMG in the multi that is part of the simplified protocol. It's a matter of balancing a couple of things. Taking a small amount of TMG can be helpful, because it will stimulate the alternative BHMT methylation pathway that is in the liver and kidneys. This will help to make some SAMe, and that is needed to methylate hydroxocobalamin to make methylcobalamin to act as a cofactor for methionine synthase. Some people do not have enough methylation capacity to do that well, and a little TMG can help.
***It may be necessary to counter the TMG by adding some DMG after the other supplements have been taken for a while, in order to slow the flow through the BHMT pathway and cause more of it to go through the methionine synthase pathway. This is something Dr. Amy Yasko recommends for autistic children, and it can help in some cases.
I'm getting confused here...and that is too easy

What you say above sounds like it may apply to me, and so far the once or perhaps twice I have tried TMG it hasnt helped. I only took a little and cant recall noticing any improvement? Can't say I cgot suddenly worse either, but at thwe time I wasn'too good before taking anyways.
***Please note that there is a distinction between TMG or betaine, on the one hand, and betaine-HCl on the other. In the latter, the betaine is used as a carrier for the HCl acid, to build up stomach acid if it is too low. However, when betaine-HCl is taken, the betaine comes in, too, and it acts as separate betaine or TMG would. To obtain the increase in acid without the betaine, the other ways of raising stomach acid that I mentioned can be used, so lomg as proper precautions are taken. That is, if hydrochloric acid is taken, it must be properly diluted so as not to damage the mouth, throat and esophagus. Allergy Research Group sells such a solution of diluted HCl. Lemon juice must be flushed from the teeth to avoid damaging the enamel.
Histamine query
'tonight I think I have worked out I may have this histamine problem I have just read about here
as I get wiped same with B12 always. Last night I went out and ate pizza and a beer. Normally that is no problem occasionally. Only at 4am I woke up(as is typical) and thought I'd try a (1/8=100mcg) small part of the newly arrived Solgar Metafolin 800mcg tablet for sleep etc...anyway I did sleep heavily unitl 9.30Am, but awake witha splitting headache and felt wiped all day ..bit of residual headache type-allergy tension in head and snuffly, could be a histamine type reaction? and maybe brought on by the l-5-mthfy rasing histamine(after already primed by the meal?)..and gthen I read the post about histamine and B12 ..and daomin (or the new stuff she took in London)...and I'm just wondering if this maybe related to my problems in not being able to take B12. Would a histamine style reaction also cause the increase tingling and reddish/puplish palms of hands and soles of feet?
Just wondering if anyone else has this..and maybe if ordering that histamine product from iherb and taking before the B12 would help?
***I'm sorry you had this experience. I'm not sure whether you had a histamine reaction or not. It's possible that there were some high histamine foods in what you ate. Also, most PWMEs/PWCs do not tolerate alcohol very well, so that might have contributed as well.
***I don't know whether you might be confusing Metafolin with melatonin. The latter is a natural hormone that does promote sleep. Metafolin may eventually help with sleep, but when some people first begin taking it, it can interfere with sleep.
I believe adding in the lecithin (soy lecithin non GMO granules from supermarket in Oz) seem to be helping, as I noted an improvement...almost vanished tingling and more energy and clearer brainfog..not perfect though. Anxiety styill there but lessened. I cant say for sure its the lecithin but It maybe. I also tried it a few years ago, and it seemed to help then too.,.although again I did multiple things.