Marky90
Science breeds knowledge, opinion breeds ignorance
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Would IVIG or steroids (like Predislone) be useful against the antibodies?
It provides symptom relief in some patients, yes.
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Would IVIG or steroids (like Predislone) be useful against the antibodies?
Would IVIG or steroids (like Predislone) be useful against the antibodies?
Yes Alex, it is for a subgroup! And these findings make sence. I think a low dose of prednison will help but prednison is a very bad drug for the longterm.
To stop autoimmune problems with drugs like this you need very high immune suppressing doses. Which is very damaging over time. How many know that drugs like this were the first line of treatment in some parts of the world in the late 70s? My aunt got something that I would call CFS after contracting Ross River virus (we lived on the banks of that river!). She was on high dose cortisol until they had to stop treatment due to side effects. These treatments suppress the problem, but do not eliminate the problem.I don't think low dose work... I have had 120mg methylprednisolon IV. It didn't work.. In MS they use 3g over 3 days with prednisolon. 5 mg daily won't do it..
To stop autoimmune problems with drugs like this you need very high immune suppressing doses. Which is very damaging over time. How many know that drugs like this were the first line of treatment in some parts of the world in the late 70s? My aunt got something that I would call CFS after contracting Ross River virus (we lived on the banks of that river!). She was on high dose cortisol until they had to stop treatment due to side effects. These treatments suppress the problem, but do not eliminate the problem.
PS Low dose use of these kinds of drugs have hormone replacement effect, not immune suppression. Its a different use of the drug.
I think this was discussed on another thread. I think the answer is no. Its about antibody suppression, not B cell suppression itself. The drug suppresses B cells in all patients, but may not target plasma cells effectively. Hence some plasma cells may lurk and need repeated treatment, or alternative treatment, but this is not easy to show - its inferred.Someone remind me, have the Ritux studies shown a correlation between responder status and the level and duration of B-cell depletion?
I think this was discussed on another thread. I think the answer is no. Its about antibody suppression, not B cell suppression itself. The drug suppresses B cells in all patients, but may not target plasma cells effectively. Hence some plasma cells may lurk and need repeated treatment, or alternative treatment, but this is not easy to show - its inferred.
Antibodies against ß2, M3 and M4 receptors were significantly elevated in CFS patients compared to controls.
We provide evidence that 29.5% of patients with CFS had elevated antibodies against one or more M acetylcholine and ß adrenergic receptors